Deciphering the binding mechanism of an anti-cancer phytochemical plumbagin with calf thymus DNA using biophysical and in silico techniques

Deciphering the binding mechanism of an anti-cancer phytochemical plumbagin with calf thymus DNA using biophysical and in silico techniques

Plumbagin (PLM), a plant derivative, is well known for a wide range of therapeutic effects in humans including anti-cancer, anti-inflammatory, anti-oxidant, and anti-microbial. Cytotoxic and genotoxic potential of this phytochemical has been studied which demands further insight. DNA being a major t...

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Bibliographic Details
Main Authors: Abdul Rahaman, Farah Anjum, Aknita Kumari, Alaa Shafie, Mahafooj Alee, Omnia Badr, Shaheer Hasan Khan, Amal Adnan Ashour, Ali Hazazi, Sultan Arif, Xin-An Zeng
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Chemistry
Subjects:
cancer
Plumbagin
groove binder
biophysical
circular dichroism
molecular simulation
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2023.1248458/full

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