NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression

NLRP3/caspase-1/GSDMD–mediated pyroptosis exerts a crucial role in astrocyte pathological injury in mouse model of depression

Emerging evidence suggests that astrocyte loss is one of the most important pathological features in the hippocampus of patients with major depressive disorder (MDD) and depressive mice. Pyroptosis is a recently discovered form of programmed cell death depending on Caspase–gasdermin D (Casp-GSDMD),...

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Bibliographic Details
Main Authors: Shanshan Li, Yiming Sun, Mengmeng Song, Yuting Song, Yinquan Fang, Qingyu Zhang, Xueting Li, Nanshan Song, Jianhua Ding, Ming Lu, Gang Hu
Format: Article
Language:English
Published: American Society for Clinical investigation 2021-12-01
Series:JCI Insight
Subjects:
Inflammation
Online Access:https://doi.org/10.1172/jci.insight.146852

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