Emerging Proteins in CRPC: Functional Roles and Clinical Implications
Prostate cancer (PCa) is the most common cancer in men in the western world, but the lack of specific and sensitive markers often leads to overtreatment of prostate cancer which eventually develops into castration-resistant prostate cancer (CRPC). Novel protein markers for diagnosis and management o...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2022.873876/full |
| _version_ | 1811258164522254336 |
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| author | Piaoping Kong Lingyu Zhang Zhengliang Zhang Kangle Feng Yiwen Sang Xiuzhi Duan Chunhua Liu Tao Sun Zhihua Tao Weiwei Liu |
| author_facet | Piaoping Kong Lingyu Zhang Zhengliang Zhang Kangle Feng Yiwen Sang Xiuzhi Duan Chunhua Liu Tao Sun Zhihua Tao Weiwei Liu |
| author_sort | Piaoping Kong |
| collection | DOAJ |
| description | Prostate cancer (PCa) is the most common cancer in men in the western world, but the lack of specific and sensitive markers often leads to overtreatment of prostate cancer which eventually develops into castration-resistant prostate cancer (CRPC). Novel protein markers for diagnosis and management of CRPC will be promising. In this review, we systematically summarize and discuss the expression pattern of emerging proteins in tissue, cell lines, and serum when castration-sensitive prostate cancer (CSPC) progresses to CRPC; focus on the proteins involved in CRPC growth, invasion, metastasis, metabolism, and immune microenvironment; summarize the current understanding of the regulatory mechanisms of emerging proteins in CSPC progressed to CRPC at the molecular level; and finally summarize the clinical applications of emerging proteins as diagnostic marker, prognostic marker, predictive marker, and therapeutic marker. |
| first_indexed | 2024-04-12T18:09:58Z |
| format | Article |
| id | doaj.art-35ce07b10acb4e399982d48020cc0234 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-04-12T18:09:58Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-35ce07b10acb4e399982d48020cc02342022-12-22T03:21:52ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2022-06-011210.3389/fonc.2022.873876873876Emerging Proteins in CRPC: Functional Roles and Clinical ImplicationsPiaoping Kong0Lingyu Zhang1Zhengliang Zhang2Kangle Feng3Yiwen Sang4Xiuzhi Duan5Chunhua Liu6Tao Sun7Zhihua Tao8Weiwei Liu9Department of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Blood Transfusion, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Laboratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, ChinaProstate cancer (PCa) is the most common cancer in men in the western world, but the lack of specific and sensitive markers often leads to overtreatment of prostate cancer which eventually develops into castration-resistant prostate cancer (CRPC). Novel protein markers for diagnosis and management of CRPC will be promising. In this review, we systematically summarize and discuss the expression pattern of emerging proteins in tissue, cell lines, and serum when castration-sensitive prostate cancer (CSPC) progresses to CRPC; focus on the proteins involved in CRPC growth, invasion, metastasis, metabolism, and immune microenvironment; summarize the current understanding of the regulatory mechanisms of emerging proteins in CSPC progressed to CRPC at the molecular level; and finally summarize the clinical applications of emerging proteins as diagnostic marker, prognostic marker, predictive marker, and therapeutic marker.https://www.frontiersin.org/articles/10.3389/fonc.2022.873876/fullproteincastration-resistant prostate cancercastration-sensitive prostate cancermarkertherapeutic resistance |
| spellingShingle | Piaoping Kong Lingyu Zhang Zhengliang Zhang Kangle Feng Yiwen Sang Xiuzhi Duan Chunhua Liu Tao Sun Zhihua Tao Weiwei Liu Emerging Proteins in CRPC: Functional Roles and Clinical Implications Frontiers in Oncology protein castration-resistant prostate cancer castration-sensitive prostate cancer marker therapeutic resistance |
| title | Emerging Proteins in CRPC: Functional Roles and Clinical Implications |
| title_full | Emerging Proteins in CRPC: Functional Roles and Clinical Implications |
| title_fullStr | Emerging Proteins in CRPC: Functional Roles and Clinical Implications |
| title_full_unstemmed | Emerging Proteins in CRPC: Functional Roles and Clinical Implications |
| title_short | Emerging Proteins in CRPC: Functional Roles and Clinical Implications |
| title_sort | emerging proteins in crpc functional roles and clinical implications |
| topic | protein castration-resistant prostate cancer castration-sensitive prostate cancer marker therapeutic resistance |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2022.873876/full |
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