Reality check for transposon enhancers
Hundreds of retrovirus-like sequences have features that suggest they might be gene enhancers, but only a small fraction displays gene-regulating activity in experiments on mouse stem cells.
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2019-05-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/47900 |
| _version_ | 1811199503387066368 |
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| author | Julie Brind'Amour Dixie L Mager |
| author_facet | Julie Brind'Amour Dixie L Mager |
| author_sort | Julie Brind'Amour |
| collection | DOAJ |
| description | Hundreds of retrovirus-like sequences have features that suggest they might be gene enhancers, but only a small fraction displays gene-regulating activity in experiments on mouse stem cells. |
| first_indexed | 2024-04-12T01:49:11Z |
| format | Article |
| id | doaj.art-35ce7bfb51224185b88f206240e08e5b |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T01:49:11Z |
| publishDate | 2019-05-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-35ce7bfb51224185b88f206240e08e5b2022-12-22T03:52:58ZengeLife Sciences Publications LtdeLife2050-084X2019-05-01810.7554/eLife.47900Reality check for transposon enhancersJulie Brind'Amour0https://orcid.org/0000-0002-9522-8571Dixie L Mager1https://orcid.org/0000-0002-5955-2550Department of Medical Genetics, University of British Columbia, Vancouver, CanadaTerry Fox Laboratory, BC Cancer, Vancouver, CanadaHundreds of retrovirus-like sequences have features that suggest they might be gene enhancers, but only a small fraction displays gene-regulating activity in experiments on mouse stem cells.https://elifesciences.org/articles/47900transposable elementsenhancersembryonic stem cellstrophoblast stem cellsCRISPRendogenous retrovirus |
| spellingShingle | Julie Brind'Amour Dixie L Mager Reality check for transposon enhancers eLife transposable elements enhancers embryonic stem cells trophoblast stem cells CRISPR endogenous retrovirus |
| title | Reality check for transposon enhancers |
| title_full | Reality check for transposon enhancers |
| title_fullStr | Reality check for transposon enhancers |
| title_full_unstemmed | Reality check for transposon enhancers |
| title_short | Reality check for transposon enhancers |
| title_sort | reality check for transposon enhancers |
| topic | transposable elements enhancers embryonic stem cells trophoblast stem cells CRISPR endogenous retrovirus |
| url | https://elifesciences.org/articles/47900 |
| work_keys_str_mv | AT juliebrindamour realitycheckfortransposonenhancers AT dixielmager realitycheckfortransposonenhancers |