Transient Inhibition of FGFR2b-ligands signaling leads to irreversible loss of cellular β-catenin organization and signaling in AER during mouse limb development.

Transient Inhibition of FGFR2b-ligands signaling leads to irreversible loss of cellular β-catenin organization and signaling in AER during mouse limb development.

The vertebrate limbs develop through coordinated series of inductive, growth and patterning events. Fibroblast Growth Factor receptor 2b (FGFR2b) signaling controls the induction of the Apical Ectodermal Ridge (AER) but its putative roles in limb outgrowth and patterning, as well as in AER morpholog...

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Bibliographic Details
Main Authors: Soula Danopoulos, Sara Parsa, Denise Al Alam, Reza Tabatabai, Sheryl Baptista, Caterina Tiozzo, Gianni Carraro, Matthew Wheeler, Guillermo Barreto, Thomas Braun, Xiaokun Li, Mohammad K Hajihosseini, Saverio Bellusci
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24167544/pdf/?tool=EBI

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