Growth and Immune Evasion of Lymph Node Metastasis
Cancer patients with lymph node (LN) metastases have a worse prognosis than those without nodal disease. However, why LN metastases correlate with reduced patient survival is poorly understood. Recent findings provide insight into mechanisms underlying tumor growth in LNs. Tumor cells and their secr...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-02-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/article/10.3389/fonc.2018.00036/full |
| _version_ | 1818608027123580928 |
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| author | Dennis Jones Dennis Jones Ethel R. Pereira Ethel R. Pereira Timothy P. Padera Timothy P. Padera |
| author_facet | Dennis Jones Dennis Jones Ethel R. Pereira Ethel R. Pereira Timothy P. Padera Timothy P. Padera |
| author_sort | Dennis Jones |
| collection | DOAJ |
| description | Cancer patients with lymph node (LN) metastases have a worse prognosis than those without nodal disease. However, why LN metastases correlate with reduced patient survival is poorly understood. Recent findings provide insight into mechanisms underlying tumor growth in LNs. Tumor cells and their secreted molecules engage stromal, myeloid, and lymphoid cells within primary tumors and in the lymphatic system, decreasing antitumor immunity and promoting tumor growth. Understanding the mechanisms of cancer survival and growth in LNs is key to designing effective therapy for the eradication of LN metastases. In addition, uncovering the implications of LN metastasis for systemic tumor burden will inform treatment decisions. In this review, we discuss the current knowledge of the seeding, growth, and further dissemination of LN metastases. |
| first_indexed | 2024-12-16T14:36:07Z |
| format | Article |
| id | doaj.art-35d0e0105a7c472db765ef509b4d1f06 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-16T14:36:07Z |
| publishDate | 2018-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-35d0e0105a7c472db765ef509b4d1f062022-12-21T22:28:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2018-02-01810.3389/fonc.2018.00036331782Growth and Immune Evasion of Lymph Node MetastasisDennis Jones0Dennis Jones1Ethel R. Pereira2Ethel R. Pereira3Timothy P. Padera4Timothy P. Padera5Edwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, Boston, MA, United StatesHarvard Medical School, Boston, MA, United StatesEdwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, Boston, MA, United StatesHarvard Medical School, Boston, MA, United StatesEdwin L. Steele Laboratories for Tumor Biology, Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital, Boston, MA, United StatesHarvard Medical School, Boston, MA, United StatesCancer patients with lymph node (LN) metastases have a worse prognosis than those without nodal disease. However, why LN metastases correlate with reduced patient survival is poorly understood. Recent findings provide insight into mechanisms underlying tumor growth in LNs. Tumor cells and their secreted molecules engage stromal, myeloid, and lymphoid cells within primary tumors and in the lymphatic system, decreasing antitumor immunity and promoting tumor growth. Understanding the mechanisms of cancer survival and growth in LNs is key to designing effective therapy for the eradication of LN metastases. In addition, uncovering the implications of LN metastasis for systemic tumor burden will inform treatment decisions. In this review, we discuss the current knowledge of the seeding, growth, and further dissemination of LN metastases.http://journal.frontiersin.org/article/10.3389/fonc.2018.00036/fulllymphaticslymph nodetumormetastasisimmunity |
| spellingShingle | Dennis Jones Dennis Jones Ethel R. Pereira Ethel R. Pereira Timothy P. Padera Timothy P. Padera Growth and Immune Evasion of Lymph Node Metastasis Frontiers in Oncology lymphatics lymph node tumor metastasis immunity |
| title | Growth and Immune Evasion of Lymph Node Metastasis |
| title_full | Growth and Immune Evasion of Lymph Node Metastasis |
| title_fullStr | Growth and Immune Evasion of Lymph Node Metastasis |
| title_full_unstemmed | Growth and Immune Evasion of Lymph Node Metastasis |
| title_short | Growth and Immune Evasion of Lymph Node Metastasis |
| title_sort | growth and immune evasion of lymph node metastasis |
| topic | lymphatics lymph node tumor metastasis immunity |
| url | http://journal.frontiersin.org/article/10.3389/fonc.2018.00036/full |
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