Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudana
A bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five...
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| Format: | Article |
| Language: | English |
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MDPI AG
2008-08-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/13/8/1530/ |
| _version_ | 1798045170550177792 |
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| author | Guang-zhi Sun Chang-chun Yuan Yi-nan Zheng Li-juan Wang Xin-feng Zhang Zhi Liu Xiang Li |
| author_facet | Guang-zhi Sun Chang-chun Yuan Yi-nan Zheng Li-juan Wang Xin-feng Zhang Zhi Liu Xiang Li |
| author_sort | Guang-zhi Sun |
| collection | DOAJ |
| description | A bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five known flavonoids – luteolin (2), isoquercitrin (3), 7-methoxyflavone (4), luteolin 7-O-glucoside (5), 4',7-dihydroxyflavone (6) – and two phenolic glycosides, leonuriside A (7) and piceoside (8). Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies, high resolution ESI mass spectroscopic analyses and comparisons with literature data. The isolated compounds 1-8 were tested for their inhibitory activities against COX-1 and COX-2. Compounds 1, 5 and 6 were found to have potent inhibitory effect on COX-2 and compounds 3-5 exhibited moderate inhibition against COX-1. |
| first_indexed | 2024-04-11T23:17:26Z |
| format | Article |
| id | doaj.art-35d1509fe8034ad5a9f7c8985894b242 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-04-11T23:17:26Z |
| publishDate | 2008-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-35d1509fe8034ad5a9f7c8985894b2422022-12-22T03:57:35ZengMDPI AGMolecules1420-30492008-08-011381530153710.3390/molecules13081530Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudanaGuang-zhi SunChang-chun YuanYi-nan ZhengLi-juan WangXin-feng ZhangZhi LiuXiang LiA bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five known flavonoids – luteolin (2), isoquercitrin (3), 7-methoxyflavone (4), luteolin 7-O-glucoside (5), 4',7-dihydroxyflavone (6) – and two phenolic glycosides, leonuriside A (7) and piceoside (8). Their structures were elucidated on the basis of extensive 1D- and 2D-NMR studies, high resolution ESI mass spectroscopic analyses and comparisons with literature data. The isolated compounds 1-8 were tested for their inhibitory activities against COX-1 and COX-2. Compounds 1, 5 and 6 were found to have potent inhibitory effect on COX-2 and compounds 3-5 exhibited moderate inhibition against COX-1.http://www.mdpi.com/1420-3049/13/8/1530/Salix matsudanamatsudone Aflavonoidcyclooxygenase inhibition. |
| spellingShingle | Guang-zhi Sun Chang-chun Yuan Yi-nan Zheng Li-juan Wang Xin-feng Zhang Zhi Liu Xiang Li Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudana Molecules Salix matsudana matsudone A flavonoid cyclooxygenase inhibition. |
| title | Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudana |
| title_full | Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudana |
| title_fullStr | Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudana |
| title_full_unstemmed | Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudana |
| title_short | Isolation and Characterization of Phenolic Compounds from the Leaves of Salix matsudana |
| title_sort | isolation and characterization of phenolic compounds from the leaves of salix matsudana |
| topic | Salix matsudana matsudone A flavonoid cyclooxygenase inhibition. |
| url | http://www.mdpi.com/1420-3049/13/8/1530/ |
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