Transporter-Mediated Mitochondrial GSH Depletion Leading to Mitochondrial Dysfunction and Rescue with αB Crystallin Peptide in RPE Cells

Transporter-Mediated Mitochondrial GSH Depletion Leading to Mitochondrial Dysfunction and Rescue with αB Crystallin Peptide in RPE Cells

Mitochondrial glutathione (mGSH) is critical for cell survival. We recently reported the localization of OGC (SLC25A11) and DIC (SLC25A10) in hRPE. Herein, we investigated the suppression of OGC and DIC and the effect of αB crystallin chaperone peptide co-treatment on RPE cell death and mitochondria...

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Bibliografiska uppgifter
Huvudupphovsmän: Parameswaran G Sreekumar, Mo Wang, Christine Spee, Srinivas R. Sadda, Ram Kannan
Materialtyp: Artikel
Språk:English
Publicerad: MDPI AG 2020-05-01
Serie:Antioxidants
Ämnen:
mitochondrial membrane anion transporters
GSH carriers
αB crystallin peptide
bioenergetics
polarized RPE
Länkar:https://www.mdpi.com/2076-3921/9/5/411

Internet

https://www.mdpi.com/2076-3921/9/5/411

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