Transporter-Mediated Mitochondrial GSH Depletion Leading to Mitochondrial Dysfunction and Rescue with αB Crystallin Peptide in RPE Cells
Mitochondrial glutathione (mGSH) is critical for cell survival. We recently reported the localization of OGC (SLC25A11) and DIC (SLC25A10) in hRPE. Herein, we investigated the suppression of OGC and DIC and the effect of αB crystallin chaperone peptide co-treatment on RPE cell death and mitochondria...
Main Authors: | Parameswaran G Sreekumar, Mo Wang, Christine Spee, Srinivas R. Sadda, Ram Kannan |
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Format: | Article |
Language: | English |
Published: |
MDPI AG
2020-05-01
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Series: | Antioxidants |
Subjects: | |
Online Access: | https://www.mdpi.com/2076-3921/9/5/411 |
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