Interleukin-10 and Interferon-γ Levels in Patients with Cutaneous Leishmaniasis Treated with Cryotherapy
Pentavalent antimonials, as the 1st choice for the treatment of cutaneous leishmaniasis (CL), have various side effects. Also, there are some reports of drug resistance. Due to its safety, cryotherapy can be a good alternative or complementary treatment in CL. The aim of this study was to explore th...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2017-09-01
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| Series: | Iranian Journal of Medical Sciences |
| Subjects: | |
| Online Access: | http://ijms.sums.ac.ir/index.php/IJMS/article/view/3115 |
| _version_ | 1818294885437931520 |
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| author | Farhad Handjani Saeed Reza Yousef Nasrin Saki Nasrin Hamidizadeh |
| author_facet | Farhad Handjani Saeed Reza Yousef Nasrin Saki Nasrin Hamidizadeh |
| author_sort | Farhad Handjani |
| collection | DOAJ |
| description | Pentavalent antimonials, as the 1st choice for the treatment of cutaneous leishmaniasis (CL), have various side effects. Also, there are some reports of drug resistance. Due to its safety, cryotherapy can be a good alternative or complementary treatment in CL. The aim of this study was to explore the possible systemic immunological mechanisms of cryotherapy besides its local effects in the treatment of CL. Twenty patients with CL were selected. The disease was confirmed via a direct smear. A venous blood sample was collected to determine IL-10 and IFN-γ levels before starting cryotherapy. Then, 1 week after 8 sessions of cryotherapy were completed (i.e., 63 d), a 2nd venous sample was taken in order to compare the results with the pretreatment levels of these cytokines using the ELISA method. Cryotherapy resulted in no change in the levels of IL-10 and significantly increased the IFN-γ levels in our patients with CL. Given these inconclusive or even mixed results, a larger sample size is needed in order to better assess the systemic immunological effects of cryotherapy. |
| first_indexed | 2024-12-13T03:38:51Z |
| format | Article |
| id | doaj.art-35d372671f9a4146b8ae742bfa51e372 |
| institution | Directory Open Access Journal |
| issn | 0253-0716 1735-3688 |
| language | English |
| last_indexed | 2024-12-13T03:38:51Z |
| publishDate | 2017-09-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Sciences |
| spelling | doaj.art-35d372671f9a4146b8ae742bfa51e3722022-12-22T00:00:59ZengShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-07161735-36882017-09-01425488492Interleukin-10 and Interferon-γ Levels in Patients with Cutaneous Leishmaniasis Treated with CryotherapyFarhad Handjani0Saeed Reza Yousef1Nasrin Saki2Nasrin Hamidizadeh3Molecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, IranMolecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, IranMolecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; and Department of Dermatology, Shiraz University of Medical Sciences, Shiraz, IranMolecular Dermatology Research Center, Shiraz University of Medical Sciences, Shiraz, IranPentavalent antimonials, as the 1st choice for the treatment of cutaneous leishmaniasis (CL), have various side effects. Also, there are some reports of drug resistance. Due to its safety, cryotherapy can be a good alternative or complementary treatment in CL. The aim of this study was to explore the possible systemic immunological mechanisms of cryotherapy besides its local effects in the treatment of CL. Twenty patients with CL were selected. The disease was confirmed via a direct smear. A venous blood sample was collected to determine IL-10 and IFN-γ levels before starting cryotherapy. Then, 1 week after 8 sessions of cryotherapy were completed (i.e., 63 d), a 2nd venous sample was taken in order to compare the results with the pretreatment levels of these cytokines using the ELISA method. Cryotherapy resulted in no change in the levels of IL-10 and significantly increased the IFN-γ levels in our patients with CL. Given these inconclusive or even mixed results, a larger sample size is needed in order to better assess the systemic immunological effects of cryotherapy.http://ijms.sums.ac.ir/index.php/IJMS/article/view/3115LeishmaniasisCutaneousInterleukin-10Interferon-gamma |
| spellingShingle | Farhad Handjani Saeed Reza Yousef Nasrin Saki Nasrin Hamidizadeh Interleukin-10 and Interferon-γ Levels in Patients with Cutaneous Leishmaniasis Treated with Cryotherapy Iranian Journal of Medical Sciences Leishmaniasis Cutaneous Interleukin-10 Interferon-gamma |
| title | Interleukin-10 and Interferon-γ Levels in Patients with Cutaneous Leishmaniasis Treated with Cryotherapy |
| title_full | Interleukin-10 and Interferon-γ Levels in Patients with Cutaneous Leishmaniasis Treated with Cryotherapy |
| title_fullStr | Interleukin-10 and Interferon-γ Levels in Patients with Cutaneous Leishmaniasis Treated with Cryotherapy |
| title_full_unstemmed | Interleukin-10 and Interferon-γ Levels in Patients with Cutaneous Leishmaniasis Treated with Cryotherapy |
| title_short | Interleukin-10 and Interferon-γ Levels in Patients with Cutaneous Leishmaniasis Treated with Cryotherapy |
| title_sort | interleukin 10 and interferon γ levels in patients with cutaneous leishmaniasis treated with cryotherapy |
| topic | Leishmaniasis Cutaneous Interleukin-10 Interferon-gamma |
| url | http://ijms.sums.ac.ir/index.php/IJMS/article/view/3115 |
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