Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus <i>Penicillium</i> sp. JY246
Four new xanthene derivatives, penicixanthenes A−D (<b>1</b>−<b>4</b>), and one known compound <b>5</b> were isolated from a marine mangrove endophytic fungus <i>Penicillium</i> sp. JY246 that was obtained from the stem of <i>...
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| Format: | Article |
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MDPI AG
2019-11-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/17/12/649 |
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| author | Meng Bai Cai-Juan Zheng Xu-Hua Nong Xue-Ming Zhou You-Ping Luo Guang-Ying Chen |
| author_facet | Meng Bai Cai-Juan Zheng Xu-Hua Nong Xue-Ming Zhou You-Ping Luo Guang-Ying Chen |
| author_sort | Meng Bai |
| collection | DOAJ |
| description | Four new xanthene derivatives, penicixanthenes A−D (<b>1</b>−<b>4</b>), and one known compound <b>5</b> were isolated from a marine mangrove endophytic fungus <i>Penicillium</i> sp. JY246 that was obtained from the stem of <i>Ceriops tagal</i>. Their structures were determined by detailed NMR, MS spectroscopic data, modified Mosher’s method, and calculated electronic circular dichroism data. All of the isolated compounds were examined for insecticidal activity. Compounds <b>2</b> and <b>3</b> showed growth inhibition activity against newly hatched larvae of <i>Helicoverpa armigera</i> Hubner with the IC<sub>50</sub> values 100 and 200 μg/mL, respectively, and compounds <b>1</b>, <b>3</b>, and <b>4</b> showed insecticidal activity against newly hatched larvae of <i>Culex quinquefasciatus</i> with LC<sub>50</sub> values of 38.5 (±1.16), 11.6 (±0.58), and 20.5 (±1) μg/mL, respectively. The four xanthene derivatives have the potential to be developed as new biopesticides. |
| first_indexed | 2024-04-11T14:06:46Z |
| format | Article |
| id | doaj.art-35d57e50fd0b4e3db486bfbc5199f095 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-04-11T14:06:46Z |
| publishDate | 2019-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-35d57e50fd0b4e3db486bfbc5199f0952022-12-22T04:19:50ZengMDPI AGMarine Drugs1660-33972019-11-01171264910.3390/md17120649md17120649Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus <i>Penicillium</i> sp. JY246Meng Bai0Cai-Juan Zheng1Xu-Hua Nong2Xue-Ming Zhou3You-Ping Luo4Guang-Ying Chen5Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, Hainan 571127, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, Hainan 571127, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, Hainan 571127, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, Hainan 571127, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, Hainan 571127, ChinaKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Hainan Normal University, Haikou, Hainan 571127, ChinaFour new xanthene derivatives, penicixanthenes A−D (<b>1</b>−<b>4</b>), and one known compound <b>5</b> were isolated from a marine mangrove endophytic fungus <i>Penicillium</i> sp. JY246 that was obtained from the stem of <i>Ceriops tagal</i>. Their structures were determined by detailed NMR, MS spectroscopic data, modified Mosher’s method, and calculated electronic circular dichroism data. All of the isolated compounds were examined for insecticidal activity. Compounds <b>2</b> and <b>3</b> showed growth inhibition activity against newly hatched larvae of <i>Helicoverpa armigera</i> Hubner with the IC<sub>50</sub> values 100 and 200 μg/mL, respectively, and compounds <b>1</b>, <b>3</b>, and <b>4</b> showed insecticidal activity against newly hatched larvae of <i>Culex quinquefasciatus</i> with LC<sub>50</sub> values of 38.5 (±1.16), 11.6 (±0.58), and 20.5 (±1) μg/mL, respectively. The four xanthene derivatives have the potential to be developed as new biopesticides.https://www.mdpi.com/1660-3397/17/12/649<i>penicillium</i> sp.<i>ceriops tagal</i>xantheneinsecticidal activity |
| spellingShingle | Meng Bai Cai-Juan Zheng Xu-Hua Nong Xue-Ming Zhou You-Ping Luo Guang-Ying Chen Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus <i>Penicillium</i> sp. JY246 Marine Drugs <i>penicillium</i> sp. <i>ceriops tagal</i> xanthene insecticidal activity |
| title | Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus <i>Penicillium</i> sp. JY246 |
| title_full | Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus <i>Penicillium</i> sp. JY246 |
| title_fullStr | Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus <i>Penicillium</i> sp. JY246 |
| title_full_unstemmed | Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus <i>Penicillium</i> sp. JY246 |
| title_short | Four New Insecticidal Xanthene Derivatives from the Mangrove-Derived Fungus <i>Penicillium</i> sp. JY246 |
| title_sort | four new insecticidal xanthene derivatives from the mangrove derived fungus i penicillium i sp jy246 |
| topic | <i>penicillium</i> sp. <i>ceriops tagal</i> xanthene insecticidal activity |
| url | https://www.mdpi.com/1660-3397/17/12/649 |
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