Decreased SIRT1 Activity Is Involved in the Acute Injury Response of Chondrocytes to Ex Vivo Injurious Mechanical Overload

Decreased SIRT1 Activity Is Involved in the Acute Injury Response of Chondrocytes to Ex Vivo Injurious Mechanical Overload

A better understanding of molecular events following cartilage injury is required to develop treatments that prevent or delay the onset of trauma-induced osteoarthritis. In this study, alterations to SIRT1 activity in bovine articular cartilage explants were evaluated in the 24 h following a mechani...

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Bibliographic Details
Main Authors: Sonali Karnik, Hessam Noori-Dokht, Taylor Williams, Amin Joukar, Stephen B. Trippel, Uma Sankar, Diane R. Wagner
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:International Journal of Molecular Sciences
Subjects:
chondrocyte injury
SIRT1
mechanobiology
impact load
post-traumatic osteoarthritis
Online Access:https://www.mdpi.com/1422-0067/24/7/6521

Internet

https://www.mdpi.com/1422-0067/24/7/6521

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