Prefrontal projections modulate recurrent circuitry in the insular cortex to support short-term memory
Summary: Short-term memory (STM) maintains information during a short delay period. How long-range and local connections interact to support STM encoding remains elusive. Here, we tackle the problem focusing on long-range projections from the medial prefrontal cortex (mPFC) to the anterior agranular...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Cell Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124724000846 |
| _version_ | 1827338902639214592 |
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| author | Jian Yao Ruiqing Hou Hongmei Fan Jiawei Liu Zhaoqin Chen Jincan Hou Qi Cheng Chengyu T. Li |
| author_facet | Jian Yao Ruiqing Hou Hongmei Fan Jiawei Liu Zhaoqin Chen Jincan Hou Qi Cheng Chengyu T. Li |
| author_sort | Jian Yao |
| collection | DOAJ |
| description | Summary: Short-term memory (STM) maintains information during a short delay period. How long-range and local connections interact to support STM encoding remains elusive. Here, we tackle the problem focusing on long-range projections from the medial prefrontal cortex (mPFC) to the anterior agranular insular cortex (aAIC) in head-fixed mice performing an olfactory delayed-response task. Optogenetic and electrophysiological experiments reveal the behavioral importance of the two regions in encoding STM information. Spike-correlogram analysis reveals strong local and cross-region functional coupling (FC) between memory neurons encoding the same information. Optogenetic suppression of mPFC-aAIC projections during the delay period reduces behavioral performance, the proportion of memory neurons, and memory-specific FC within the aAIC, whereas optogenetic excitation enhances all of them. mPFC-aAIC projections also bidirectionally modulate the efficacy of STM-information transfer, measured by the contribution of FC spiking pairs to the memory-coding ability of following neurons. Thus, prefrontal projections modulate insular neurons’ functional connectivity and memory-coding ability to support STM. |
| first_indexed | 2024-03-07T19:42:20Z |
| format | Article |
| id | doaj.art-35d64f613fd54d6289b805783440bb16 |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-03-07T19:42:20Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-35d64f613fd54d6289b805783440bb162024-02-29T05:18:53ZengElsevierCell Reports2211-12472024-02-01432113756Prefrontal projections modulate recurrent circuitry in the insular cortex to support short-term memoryJian Yao0Ruiqing Hou1Hongmei Fan2Jiawei Liu3Zhaoqin Chen4Jincan Hou5Qi Cheng6Chengyu T. Li7Institute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; Lingang Laboratory, Shanghai 200031, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; University of Chinese Academy of Sciences, Beijing 100049, ChinaShanghai Center for Brain Science and Brain-Inspired Technology, Shanghai 200031, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; Lingang Laboratory, Shanghai 200031, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; Lingang Laboratory, Shanghai 200031, ChinaInstitute of Neuroscience, State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China; Lingang Laboratory, Shanghai 200031, China; Shanghai Center for Brain Science and Brain-Inspired Technology, Shanghai 200031, China; Corresponding authorSummary: Short-term memory (STM) maintains information during a short delay period. How long-range and local connections interact to support STM encoding remains elusive. Here, we tackle the problem focusing on long-range projections from the medial prefrontal cortex (mPFC) to the anterior agranular insular cortex (aAIC) in head-fixed mice performing an olfactory delayed-response task. Optogenetic and electrophysiological experiments reveal the behavioral importance of the two regions in encoding STM information. Spike-correlogram analysis reveals strong local and cross-region functional coupling (FC) between memory neurons encoding the same information. Optogenetic suppression of mPFC-aAIC projections during the delay period reduces behavioral performance, the proportion of memory neurons, and memory-specific FC within the aAIC, whereas optogenetic excitation enhances all of them. mPFC-aAIC projections also bidirectionally modulate the efficacy of STM-information transfer, measured by the contribution of FC spiking pairs to the memory-coding ability of following neurons. Thus, prefrontal projections modulate insular neurons’ functional connectivity and memory-coding ability to support STM.http://www.sciencedirect.com/science/article/pii/S2211124724000846CP: Neuroscience |
| spellingShingle | Jian Yao Ruiqing Hou Hongmei Fan Jiawei Liu Zhaoqin Chen Jincan Hou Qi Cheng Chengyu T. Li Prefrontal projections modulate recurrent circuitry in the insular cortex to support short-term memory Cell Reports CP: Neuroscience |
| title | Prefrontal projections modulate recurrent circuitry in the insular cortex to support short-term memory |
| title_full | Prefrontal projections modulate recurrent circuitry in the insular cortex to support short-term memory |
| title_fullStr | Prefrontal projections modulate recurrent circuitry in the insular cortex to support short-term memory |
| title_full_unstemmed | Prefrontal projections modulate recurrent circuitry in the insular cortex to support short-term memory |
| title_short | Prefrontal projections modulate recurrent circuitry in the insular cortex to support short-term memory |
| title_sort | prefrontal projections modulate recurrent circuitry in the insular cortex to support short term memory |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124724000846 |
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