Coenzyme Q10 in the eye isomerizes by sunlight irradiation
Abstract Photoisomerization of lipids has been well studied. As for the eyes, photoisomerization from 11-cis isomer to all-trans-retinal is well-known as the first step of the visual transduction in the photoreceptors. In addition to that, there would be other ocular lipids that undergo photoisomeri...
| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-07-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-16343-8 |
| _version_ | 1818196932922703872 |
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| author | Md. Al Mamun Md. Mahamodun Nabi Tomohito Sato Shuhei Aramaki Yusuke Takanashi Takumi Sakamoto Kaito Hizume Chikako Mori Maiha Yasue Masataka Ozaki Ariful Islam Tomoaki Kahyo Makoto Horikawa Yutaka Takahashi Shigetoshi Okazaki Kentaro Ohishi Yu Nagashima Keiji Seno Yoshihiro Hotta Mitsutoshi Setou |
| author_facet | Md. Al Mamun Md. Mahamodun Nabi Tomohito Sato Shuhei Aramaki Yusuke Takanashi Takumi Sakamoto Kaito Hizume Chikako Mori Maiha Yasue Masataka Ozaki Ariful Islam Tomoaki Kahyo Makoto Horikawa Yutaka Takahashi Shigetoshi Okazaki Kentaro Ohishi Yu Nagashima Keiji Seno Yoshihiro Hotta Mitsutoshi Setou |
| author_sort | Md. Al Mamun |
| collection | DOAJ |
| description | Abstract Photoisomerization of lipids has been well studied. As for the eyes, photoisomerization from 11-cis isomer to all-trans-retinal is well-known as the first step of the visual transduction in the photoreceptors. In addition to that, there would be other ocular lipids that undergo photoisomerization, which may be involved in ocular health and function. To explore any photoisomerizable lipids in the eyes, the nonirradiated and sunlight-irradiated eyeball extracts were subjected to liquid chromatography-mass spectrometry analysis, followed by the identification of the decreased lipid species in the irradiated extracts. Surprisingly, more than nine hundred lipid species were decreased in the irradiated extracts. Three lipid species, coenzyme Q10 (CoQ10), triglyceride(58:4), and coenzyme Q9, were decreased both significantly (p < 0.05) and by more than two-fold, where CoQ10 showed the most significant decrease. Later, photoisomerization was identified as the prominent cause underlying the decrease of CoQ10. Interestingly, CoQ10 in the sunlight-irradiated fresh eyeballs was also isomerized. Both the visible light and ultraviolet radiation were capable of producing CoQ10 isomer, while the latter showed rapid action. This study is believed to enhance our understanding of the biochemistry and photodamage of the eye and can potentially contribute to the advancement of opto-lipidomics. |
| first_indexed | 2024-12-12T01:41:57Z |
| format | Article |
| id | doaj.art-35da13d8e6504e47bfbe2b723513c5b7 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-12T01:41:57Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj.art-35da13d8e6504e47bfbe2b723513c5b72022-12-22T00:42:40ZengNature PortfolioScientific Reports2045-23222022-07-0112111410.1038/s41598-022-16343-8Coenzyme Q10 in the eye isomerizes by sunlight irradiationMd. Al Mamun0Md. Mahamodun Nabi1Tomohito Sato2Shuhei Aramaki3Yusuke Takanashi4Takumi Sakamoto5Kaito Hizume6Chikako Mori7Maiha Yasue8Masataka Ozaki9Ariful Islam10Tomoaki Kahyo11Makoto Horikawa12Yutaka Takahashi13Shigetoshi Okazaki14Kentaro Ohishi15Yu Nagashima16Keiji Seno17Yoshihiro Hotta18Mitsutoshi Setou19Department of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Radiation Oncology, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineDepartment of Molecular Biotechnology, Graduate School of Advanced Science of Matter, Hiroshima UniversityDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineHAMAMATSU BioPhotonics Innovation Chair, Institute for Medical Photonics Research, Preeminent Medical Photonics Education and Research Center, Hamamatsu University School of MedicineInstitute for Medical Photonics Research, Preeminent Medical Photonics Education and Research Center, Hamamatsu University School of MedicineInstitute for Medical Photonics Research, Preeminent Medical Photonics Education and Research Center, Hamamatsu University School of MedicineDepartment of Biology, Hamamatsu University School of MedicineDepartment of Ophthalmology, Hamamatsu University School of MedicineDepartment of Cellular and Molecular Anatomy, Hamamatsu University School of MedicineAbstract Photoisomerization of lipids has been well studied. As for the eyes, photoisomerization from 11-cis isomer to all-trans-retinal is well-known as the first step of the visual transduction in the photoreceptors. In addition to that, there would be other ocular lipids that undergo photoisomerization, which may be involved in ocular health and function. To explore any photoisomerizable lipids in the eyes, the nonirradiated and sunlight-irradiated eyeball extracts were subjected to liquid chromatography-mass spectrometry analysis, followed by the identification of the decreased lipid species in the irradiated extracts. Surprisingly, more than nine hundred lipid species were decreased in the irradiated extracts. Three lipid species, coenzyme Q10 (CoQ10), triglyceride(58:4), and coenzyme Q9, were decreased both significantly (p < 0.05) and by more than two-fold, where CoQ10 showed the most significant decrease. Later, photoisomerization was identified as the prominent cause underlying the decrease of CoQ10. Interestingly, CoQ10 in the sunlight-irradiated fresh eyeballs was also isomerized. Both the visible light and ultraviolet radiation were capable of producing CoQ10 isomer, while the latter showed rapid action. This study is believed to enhance our understanding of the biochemistry and photodamage of the eye and can potentially contribute to the advancement of opto-lipidomics.https://doi.org/10.1038/s41598-022-16343-8 |
| spellingShingle | Md. Al Mamun Md. Mahamodun Nabi Tomohito Sato Shuhei Aramaki Yusuke Takanashi Takumi Sakamoto Kaito Hizume Chikako Mori Maiha Yasue Masataka Ozaki Ariful Islam Tomoaki Kahyo Makoto Horikawa Yutaka Takahashi Shigetoshi Okazaki Kentaro Ohishi Yu Nagashima Keiji Seno Yoshihiro Hotta Mitsutoshi Setou Coenzyme Q10 in the eye isomerizes by sunlight irradiation Scientific Reports |
| title | Coenzyme Q10 in the eye isomerizes by sunlight irradiation |
| title_full | Coenzyme Q10 in the eye isomerizes by sunlight irradiation |
| title_fullStr | Coenzyme Q10 in the eye isomerizes by sunlight irradiation |
| title_full_unstemmed | Coenzyme Q10 in the eye isomerizes by sunlight irradiation |
| title_short | Coenzyme Q10 in the eye isomerizes by sunlight irradiation |
| title_sort | coenzyme q10 in the eye isomerizes by sunlight irradiation |
| url | https://doi.org/10.1038/s41598-022-16343-8 |
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