Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences
Abstract Background During evolution, genes can experience duplications, losses, inversions and gene conversions. Why certain genes are more dynamic than others is poorly understood. Here we examine how several Sgs genes encoding glue proteins, which make up a bioadhesive that sticks the animal duri...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | BMC Ecology and Evolution |
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| Online Access: | https://doi.org/10.1186/s12862-023-02178-y |
| _version_ | 1827328808098725888 |
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| author | Manon Monier Isabelle Nuez Flora Borne Virginie Courtier-Orgogozo |
| author_facet | Manon Monier Isabelle Nuez Flora Borne Virginie Courtier-Orgogozo |
| author_sort | Manon Monier |
| collection | DOAJ |
| description | Abstract Background During evolution, genes can experience duplications, losses, inversions and gene conversions. Why certain genes are more dynamic than others is poorly understood. Here we examine how several Sgs genes encoding glue proteins, which make up a bioadhesive that sticks the animal during metamorphosis, have evolved in Drosophila species. Results We examined high-quality genome assemblies of 24 Drosophila species to study the evolutionary dynamics of four glue genes that are present in D. melanogaster and are part of the same gene family - Sgs1, Sgs3, Sgs7 and Sgs8 - across approximately 30 millions of years. We annotated a total of 102 Sgs genes and grouped them into 4 subfamilies. We present here a new nomenclature for these Sgs genes based on protein sequence conservation, genomic location and presence/absence of internal repeats. Two types of glue genes were uncovered. The first category (Sgs1, Sgs3x, Sgs3e) showed a few gene losses but no duplication, no local inversion and no gene conversion. The second group (Sgs3b, Sgs7, Sgs8) exhibited multiple events of gene losses, gene duplications, local inversions and gene conversions. Our data suggest that the presence of short “new glue” genes near the genes of the latter group may have accelerated their dynamics. Conclusions Our comparative analysis suggests that the evolutionary dynamics of glue genes is influenced by genomic context. Our molecular, phylogenetic and comparative analysis of the four glue genes Sgs1, Sgs3, Sgs7 and Sgs8 provides the foundation for investigating the role of the various glue genes during Drosophila life. |
| first_indexed | 2024-03-07T15:23:38Z |
| format | Article |
| id | doaj.art-35da8478c7ba4baa81a0a4e8427e7eb9 |
| institution | Directory Open Access Journal |
| issn | 2730-7182 |
| language | English |
| last_indexed | 2024-03-07T15:23:38Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ecology and Evolution |
| spelling | doaj.art-35da8478c7ba4baa81a0a4e8427e7eb92024-03-05T17:26:03ZengBMCBMC Ecology and Evolution2730-71822024-02-0124112110.1186/s12862-023-02178-yHigher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequencesManon Monier0Isabelle Nuez1Flora Borne2Virginie Courtier-Orgogozo3Université Paris Cité, CNRS, Institut Jacques MonodUniversité Paris Cité, CNRS, Institut Jacques MonodUniversité Paris Cité, CNRS, Institut Jacques MonodUniversité Paris Cité, CNRS, Institut Jacques MonodAbstract Background During evolution, genes can experience duplications, losses, inversions and gene conversions. Why certain genes are more dynamic than others is poorly understood. Here we examine how several Sgs genes encoding glue proteins, which make up a bioadhesive that sticks the animal during metamorphosis, have evolved in Drosophila species. Results We examined high-quality genome assemblies of 24 Drosophila species to study the evolutionary dynamics of four glue genes that are present in D. melanogaster and are part of the same gene family - Sgs1, Sgs3, Sgs7 and Sgs8 - across approximately 30 millions of years. We annotated a total of 102 Sgs genes and grouped them into 4 subfamilies. We present here a new nomenclature for these Sgs genes based on protein sequence conservation, genomic location and presence/absence of internal repeats. Two types of glue genes were uncovered. The first category (Sgs1, Sgs3x, Sgs3e) showed a few gene losses but no duplication, no local inversion and no gene conversion. The second group (Sgs3b, Sgs7, Sgs8) exhibited multiple events of gene losses, gene duplications, local inversions and gene conversions. Our data suggest that the presence of short “new glue” genes near the genes of the latter group may have accelerated their dynamics. Conclusions Our comparative analysis suggests that the evolutionary dynamics of glue genes is influenced by genomic context. Our molecular, phylogenetic and comparative analysis of the four glue genes Sgs1, Sgs3, Sgs7 and Sgs8 provides the foundation for investigating the role of the various glue genes during Drosophila life.https://doi.org/10.1186/s12862-023-02178-yGlue genesBioadhesiveSgsMucinGene familyGene diversification |
| spellingShingle | Manon Monier Isabelle Nuez Flora Borne Virginie Courtier-Orgogozo Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences BMC Ecology and Evolution Glue genes Bioadhesive Sgs Mucin Gene family Gene diversification |
| title | Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences |
| title_full | Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences |
| title_fullStr | Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences |
| title_full_unstemmed | Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences |
| title_short | Higher evolutionary dynamics of gene copy number for Drosophila glue genes located near short repeat sequences |
| title_sort | higher evolutionary dynamics of gene copy number for drosophila glue genes located near short repeat sequences |
| topic | Glue genes Bioadhesive Sgs Mucin Gene family Gene diversification |
| url | https://doi.org/10.1186/s12862-023-02178-y |
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