Sialochemical Analysis: A Portal for the Oral Diagnostician
Background: Depressive disorders, worldwide, may rank second by the year 2020. In India; about 10 million people suffer from depressive disorders, the prevalence rate being recorded as 31.2 for every 1000 individuals. A significant impairment of all personal hygiene may occur due to a depressive...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2014-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4375/8134_CE(RA)_PF1(AG)_F(T)_PFA(P)_PF2(PP).pdf |
| Summary: | Background: Depressive disorders, worldwide, may rank
second by the year 2020. In India; about 10 million people suffer
from depressive disorders, the prevalence rate being recorded
as 31.2 for every 1000 individuals. A significant impairment of all
personal hygiene may occur due to a depressive episode which
in turn may result in altered biochemical composition of some
important salivary parameters.
The present study was done to assess the relationship and bring
about a comparison of certain selective sialochemical alterations
between normal and subjects with depressive disorders.
Settings and Design: The present study was a hospital- based
clinical cross-sectional study which was conducted in Bhopal,
the heart of Madhya Pradesh, India. The survey period extended
over a period of one year and two months, from May 2009 to
July 2010.
Material and Methods: Unstimulated whole saliva was analysed
biochemically for α- amylase, calcium, sodium, potassium,
total proteins and urea. The data obtained in this study were
statistically analyzed by using Unpaired Student’s t–test.
Results: Salivary calcium and total protein levels were found to
be statistically significant among all three groups (p< 0.0001).
Salivary amylase levels between Groups II and III and between
Groups I and III (p< 0.0001) was statistically significant while the
salivary urea levels between Groups I and Group II and between
Groups I and III were found to be statistically significant (p<
0.0001). However, there was no statistical difference in their
sodium and potassium levels.
Conclusions: It was observed that drugs do affect the salivary
composition. It was observed that cyclic antidepressants produced significant alteration in the sialochemical constituents of
saliva as compared to TCAs and TeCAs. |
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| ISSN: | 2249-782X 0973-709X |