Sialochemical Analysis: A Portal for the Oral Diagnostician
Background: Depressive disorders, worldwide, may rank second by the year 2020. In India; about 10 million people suffer from depressive disorders, the prevalence rate being recorded as 31.2 for every 1000 individuals. A significant impairment of all personal hygiene may occur due to a depressive...
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| Format: | Article |
| Language: | English |
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JCDR Research and Publications Private Limited
2014-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/4375/8134_CE(RA)_PF1(AG)_F(T)_PFA(P)_PF2(PP).pdf |
| _version_ | 1818325678626439168 |
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| author | Annette Milton B. Ajay Bhambal |
| author_facet | Annette Milton B. Ajay Bhambal |
| author_sort | Annette Milton B. |
| collection | DOAJ |
| description | Background: Depressive disorders, worldwide, may rank
second by the year 2020. In India; about 10 million people suffer
from depressive disorders, the prevalence rate being recorded
as 31.2 for every 1000 individuals. A significant impairment of all
personal hygiene may occur due to a depressive episode which
in turn may result in altered biochemical composition of some
important salivary parameters.
The present study was done to assess the relationship and bring
about a comparison of certain selective sialochemical alterations
between normal and subjects with depressive disorders.
Settings and Design: The present study was a hospital- based
clinical cross-sectional study which was conducted in Bhopal,
the heart of Madhya Pradesh, India. The survey period extended
over a period of one year and two months, from May 2009 to
July 2010.
Material and Methods: Unstimulated whole saliva was analysed
biochemically for α- amylase, calcium, sodium, potassium,
total proteins and urea. The data obtained in this study were
statistically analyzed by using Unpaired Student’s t–test.
Results: Salivary calcium and total protein levels were found to
be statistically significant among all three groups (p< 0.0001).
Salivary amylase levels between Groups II and III and between
Groups I and III (p< 0.0001) was statistically significant while the
salivary urea levels between Groups I and Group II and between
Groups I and III were found to be statistically significant (p<
0.0001). However, there was no statistical difference in their
sodium and potassium levels.
Conclusions: It was observed that drugs do affect the salivary
composition. It was observed that cyclic antidepressants produced significant alteration in the sialochemical constituents of
saliva as compared to TCAs and TeCAs. |
| first_indexed | 2024-12-13T11:48:18Z |
| format | Article |
| id | doaj.art-35dedbade8b34dee8f8d478b010b59e8 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-12-13T11:48:18Z |
| publishDate | 2014-05-01 |
| publisher | JCDR Research and Publications Private Limited |
| record_format | Article |
| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-35dedbade8b34dee8f8d478b010b59e82022-12-21T23:47:26ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-05-0185ZC43ZC4810.7860/JCDR/2014/8134.4375Sialochemical Analysis: A Portal for the Oral DiagnosticianAnnette Milton B.0Ajay Bhambal1Assistant Professor, Department of Oral Medicine and Radiology, People’s College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India.Professor, Department of Oral Medicine and Radiology, People’s College of Dental Sciences and Research Centre, Bhopal, Madhya Pradesh, India.Background: Depressive disorders, worldwide, may rank second by the year 2020. In India; about 10 million people suffer from depressive disorders, the prevalence rate being recorded as 31.2 for every 1000 individuals. A significant impairment of all personal hygiene may occur due to a depressive episode which in turn may result in altered biochemical composition of some important salivary parameters. The present study was done to assess the relationship and bring about a comparison of certain selective sialochemical alterations between normal and subjects with depressive disorders. Settings and Design: The present study was a hospital- based clinical cross-sectional study which was conducted in Bhopal, the heart of Madhya Pradesh, India. The survey period extended over a period of one year and two months, from May 2009 to July 2010. Material and Methods: Unstimulated whole saliva was analysed biochemically for α- amylase, calcium, sodium, potassium, total proteins and urea. The data obtained in this study were statistically analyzed by using Unpaired Student’s t–test. Results: Salivary calcium and total protein levels were found to be statistically significant among all three groups (p< 0.0001). Salivary amylase levels between Groups II and III and between Groups I and III (p< 0.0001) was statistically significant while the salivary urea levels between Groups I and Group II and between Groups I and III were found to be statistically significant (p< 0.0001). However, there was no statistical difference in their sodium and potassium levels. Conclusions: It was observed that drugs do affect the salivary composition. It was observed that cyclic antidepressants produced significant alteration in the sialochemical constituents of saliva as compared to TCAs and TeCAs.https://jcdr.net/articles/PDF/4375/8134_CE(RA)_PF1(AG)_F(T)_PFA(P)_PF2(PP).pdfdepressionsialochemistryunstimulated saliva |
| spellingShingle | Annette Milton B. Ajay Bhambal Sialochemical Analysis: A Portal for the Oral Diagnostician Journal of Clinical and Diagnostic Research depression sialochemistry unstimulated saliva |
| title | Sialochemical Analysis: A Portal for the Oral Diagnostician |
| title_full | Sialochemical Analysis: A Portal for the Oral Diagnostician |
| title_fullStr | Sialochemical Analysis: A Portal for the Oral Diagnostician |
| title_full_unstemmed | Sialochemical Analysis: A Portal for the Oral Diagnostician |
| title_short | Sialochemical Analysis: A Portal for the Oral Diagnostician |
| title_sort | sialochemical analysis a portal for the oral diagnostician |
| topic | depression sialochemistry unstimulated saliva |
| url | https://jcdr.net/articles/PDF/4375/8134_CE(RA)_PF1(AG)_F(T)_PFA(P)_PF2(PP).pdf |
| work_keys_str_mv | AT annettemiltonb sialochemicalanalysisaportalfortheoraldiagnostician AT ajaybhambal sialochemicalanalysisaportalfortheoraldiagnostician |