Crucial role of Anxa2 in cancer progression: highlights on its novel regulatory mechanism
Anxa2 is the most studied member of the calcium-mediated phospholipid-binding protein family annexins and is a biomarker in cancers. In this review, we listed clinical findings and confirmed the value of Anxa2 in early diagnosis and prognostic prediction due to its overexpression and adverse effect...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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China Anti-Cancer Association
2019-12-01
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| Series: | Cancer Biology & Medicine |
| Subjects: | |
| Online Access: | http://www.cancerbiomed.org/index.php/cocr/article/view/1514 |
| _version_ | 1818017512626847744 |
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| author | Tong Wang Zhiyong Wang Ruifang Niu Liang Wang |
| author_facet | Tong Wang Zhiyong Wang Ruifang Niu Liang Wang |
| author_sort | Tong Wang |
| collection | DOAJ |
| description | Anxa2 is the most studied member of the calcium-mediated phospholipid-binding protein family annexins and is a biomarker in cancers. In this review, we listed clinical findings and confirmed the value of Anxa2 in early diagnosis and prognostic prediction due to its overexpression and adverse effect on the outcome in most tumors. Anxa2 plays a pivotal role in cancer cell proliferation, migration, invasion, metastasis, and treatment resistance. Improved understanding of its cancer-promoting function might make it an ideal target for cancer therapy. Here, we systematically summarized the mechanism of Anxa2 in regulating epithelial-mesenchymal transition (EMT), cytoskeleton dynamicity, cell cycle, apoptosis, angiogenesis, and immunology by using various tumor models. These data emphasize the potential of Anxa2 for targeted intervention in tumors. Altering Anxa2 expression, neutralizing the cell surface Anxa2, or inhibiting its activation, such as through Tyr23 phosphorylation, could be considered based on the regulatory mechanism of Anxa2 in tumor progression. |
| first_indexed | 2024-04-14T07:29:03Z |
| format | Article |
| id | doaj.art-35e00562561344d4b9b16d8c8ad86e0d |
| institution | Directory Open Access Journal |
| issn | 2095-3941 2095-3941 |
| language | English |
| last_indexed | 2024-04-14T07:29:03Z |
| publishDate | 2019-12-01 |
| publisher | China Anti-Cancer Association |
| record_format | Article |
| series | Cancer Biology & Medicine |
| spelling | doaj.art-35e00562561344d4b9b16d8c8ad86e0d2022-12-22T02:05:56ZengChina Anti-Cancer AssociationCancer Biology & Medicine2095-39412095-39412019-12-0116467168710.20892/j.issn.2095-3941.2019.0228CBM-2019-0228Crucial role of Anxa2 in cancer progression: highlights on its novel regulatory mechanismTong Wang0Zhiyong Wang1Ruifang Niu2Liang Wang3Second Department of Breast TumorPublic Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, ChinaPublic Laboratory, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin 300060, ChinaModern Distance Education College, Nankai University, Tianjin 300071, ChinaAnxa2 is the most studied member of the calcium-mediated phospholipid-binding protein family annexins and is a biomarker in cancers. In this review, we listed clinical findings and confirmed the value of Anxa2 in early diagnosis and prognostic prediction due to its overexpression and adverse effect on the outcome in most tumors. Anxa2 plays a pivotal role in cancer cell proliferation, migration, invasion, metastasis, and treatment resistance. Improved understanding of its cancer-promoting function might make it an ideal target for cancer therapy. Here, we systematically summarized the mechanism of Anxa2 in regulating epithelial-mesenchymal transition (EMT), cytoskeleton dynamicity, cell cycle, apoptosis, angiogenesis, and immunology by using various tumor models. These data emphasize the potential of Anxa2 for targeted intervention in tumors. Altering Anxa2 expression, neutralizing the cell surface Anxa2, or inhibiting its activation, such as through Tyr23 phosphorylation, could be considered based on the regulatory mechanism of Anxa2 in tumor progression.http://www.cancerbiomed.org/index.php/cocr/article/view/1514anxa2cancerdiagnosisprognosismetastasistreatment resistance |
| spellingShingle | Tong Wang Zhiyong Wang Ruifang Niu Liang Wang Crucial role of Anxa2 in cancer progression: highlights on its novel regulatory mechanism Cancer Biology & Medicine anxa2 cancer diagnosis prognosis metastasis treatment resistance |
| title | Crucial role of Anxa2 in cancer progression: highlights on its novel regulatory mechanism |
| title_full | Crucial role of Anxa2 in cancer progression: highlights on its novel regulatory mechanism |
| title_fullStr | Crucial role of Anxa2 in cancer progression: highlights on its novel regulatory mechanism |
| title_full_unstemmed | Crucial role of Anxa2 in cancer progression: highlights on its novel regulatory mechanism |
| title_short | Crucial role of Anxa2 in cancer progression: highlights on its novel regulatory mechanism |
| title_sort | crucial role of anxa2 in cancer progression highlights on its novel regulatory mechanism |
| topic | anxa2 cancer diagnosis prognosis metastasis treatment resistance |
| url | http://www.cancerbiomed.org/index.php/cocr/article/view/1514 |
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