Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates
OBJECTIVE: This study investigated interleukin-10 and nitric oxide plasma levels following surgery to determine whether there is a correlation between these two variables and if different desflurane anesthesia flow rates influence nitric oxide and interleukin-10 concentrations in circulation. MA...
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Sociedade Brasileira de Anestesiologia
2014-07-01
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| Series: | Revista Brasileira de Anestesiologia |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942014000400292&lng=en&tlng=en |
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| author | Dilek Kalayci Bayazit Dikmen Murat Kaçmaz Vildan Taspinar Dilsen Örnek Özlem Turan |
| author_facet | Dilek Kalayci Bayazit Dikmen Murat Kaçmaz Vildan Taspinar Dilsen Örnek Özlem Turan |
| author_sort | Dilek Kalayci |
| collection | DOAJ |
| description | OBJECTIVE: This study investigated interleukin-10 and nitric oxide plasma levels following surgery to determine whether there is a correlation between these two variables and if different desflurane anesthesia flow rates influence nitric oxide and interleukin-10 concentrations in circulation. MATERIALS AND METHODS: Forty patients between 18 and 70 years and ASA I-II physical status who were scheduled to undergo thyroidectomy were enrolled in the study. INTERVENTIONS: Patients were allocated into two groups to receive two different desflurane anesthesia flow rates: high flow (Group HF) and low flow (Group LF). MEASUREMENTS: Blood samples were drawn at the beginning (t 0) and end (t 1) of the operation and after 24 h (t 2). Plasma interleukin-10 and nitric oxide levels were measured using an enzyme-linked-immunosorbent assay and a Griess reagents kit, respectively. Hemodynamic and respiratory parameters were assessed. RESULTS: There was no statistically significant difference between the two groups with regard to interleukin-10 levels at the times of measurement. Interleukin-10 levels were increased equally in both groups at times t 1 and t 2 compared with preoperative concentrations. For both groups, nitric oxide circulating concentrations were significantly reduced at times t 1 and t 2 compared with preoperative concentrations. However, the nitric oxide value was lower for Group HF compared to Group LF at t 2. No correlation was found between the IL-10 and nitric oxide levels. CONCLUSION: Clinical usage of two different flow anesthesia forms with desflurane may increase interleukin-10 levels both in Group HF and Group LF; nitric oxide levels circulating concentrations were significantly reduced at times t 1 and t 2 compared with preoperative concentrations; however, at 24 h postoperatively they were higher in Group LF compared to Group HF. No correlation was detected between interleukin-10 and nitric oxide levels. |
| first_indexed | 2024-04-13T20:51:32Z |
| format | Article |
| id | doaj.art-35e2aeafea3548e5bae0c55bfe04a3bc |
| institution | Directory Open Access Journal |
| issn | 1806-907X |
| language | English |
| last_indexed | 2024-04-13T20:51:32Z |
| publishDate | 2014-07-01 |
| publisher | Sociedade Brasileira de Anestesiologia |
| record_format | Article |
| series | Revista Brasileira de Anestesiologia |
| spelling | doaj.art-35e2aeafea3548e5bae0c55bfe04a3bc2022-12-22T02:30:30ZengSociedade Brasileira de AnestesiologiaRevista Brasileira de Anestesiologia1806-907X2014-07-0164429229810.1016/j.bjane.2013.06.008S0034-70942014000400292Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow ratesDilek KalayciBayazit DikmenMurat KaçmazVildan TaspinarDilsen ÖrnekÖzlem TuranOBJECTIVE: This study investigated interleukin-10 and nitric oxide plasma levels following surgery to determine whether there is a correlation between these two variables and if different desflurane anesthesia flow rates influence nitric oxide and interleukin-10 concentrations in circulation. MATERIALS AND METHODS: Forty patients between 18 and 70 years and ASA I-II physical status who were scheduled to undergo thyroidectomy were enrolled in the study. INTERVENTIONS: Patients were allocated into two groups to receive two different desflurane anesthesia flow rates: high flow (Group HF) and low flow (Group LF). MEASUREMENTS: Blood samples were drawn at the beginning (t 0) and end (t 1) of the operation and after 24 h (t 2). Plasma interleukin-10 and nitric oxide levels were measured using an enzyme-linked-immunosorbent assay and a Griess reagents kit, respectively. Hemodynamic and respiratory parameters were assessed. RESULTS: There was no statistically significant difference between the two groups with regard to interleukin-10 levels at the times of measurement. Interleukin-10 levels were increased equally in both groups at times t 1 and t 2 compared with preoperative concentrations. For both groups, nitric oxide circulating concentrations were significantly reduced at times t 1 and t 2 compared with preoperative concentrations. However, the nitric oxide value was lower for Group HF compared to Group LF at t 2. No correlation was found between the IL-10 and nitric oxide levels. CONCLUSION: Clinical usage of two different flow anesthesia forms with desflurane may increase interleukin-10 levels both in Group HF and Group LF; nitric oxide levels circulating concentrations were significantly reduced at times t 1 and t 2 compared with preoperative concentrations; however, at 24 h postoperatively they were higher in Group LF compared to Group HF. No correlation was detected between interleukin-10 and nitric oxide levels.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942014000400292&lng=en&tlng=enAnestesia generalInterleucinaCirugíaÓxido nítricoDesflurano |
| spellingShingle | Dilek Kalayci Bayazit Dikmen Murat Kaçmaz Vildan Taspinar Dilsen Örnek Özlem Turan Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates Revista Brasileira de Anestesiologia Anestesia general Interleucina Cirugía Óxido nítrico Desflurano |
| title | Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates |
| title_full | Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates |
| title_fullStr | Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates |
| title_full_unstemmed | Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates |
| title_short | Plasma levels of interleukin-10 and nitric oxide in response to two different desflurane anesthesia flow rates |
| title_sort | plasma levels of interleukin 10 and nitric oxide in response to two different desflurane anesthesia flow rates |
| topic | Anestesia general Interleucina Cirugía Óxido nítrico Desflurano |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0034-70942014000400292&lng=en&tlng=en |
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