Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells

Up-regulation of hypoxia inducible factor-1α by cobalt chloride correlates with proliferation and apoptosis in PC-2 cells

<p>Abstract</p> <p>Background</p> <p>The exact mechanism of the effects of hypoxia on the proliferation and apoptosis in carcinoma cells is still conflicting. This study investigated the variation of hypoxia-inducible factor-1α(HIF-1α) expression and the apoptosis effec...

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Bibliographic Details
Main Authors: Dai Zhi-Jun, Gao Jie, Ma Xiao-Bin, Yan Kun, Liu Xiao-Xu, Kang Hua-Feng, Ji Zong-Zheng, Guan Hai-Tao, Wang Xi-Jing
Format: Article
Language:English
Published: BMC 2012-03-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Pancreatic carcinoma
Hypoxia
Cobalt chloride
HIF-1α
Apoptosis
Proliferation
Online Access:http://www.jeccr.com/content/31/1/28

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