Differential Expression of miRNAs Contributes to Tumor Aggressiveness and Racial Disparity in African American Men with Prostate Cancer
Prostate cancer is the leading cancer in incidence and second leading cause of cancer mortality in US men. African American men have significantly higher incidence and mortality rates from prostate cancer than European American men. Previous studies reported that the disparity in prostate cancer sur...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/8/2331 |
| _version_ | 1797606050060304384 |
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| author | Richard Ottman Kavya Ganapathy Hui-Yi Lin Carlos Diaz Osterman Julie Dutil Jaime Matta Gilberto Ruiz-Deya Liang Wang Kosj Yamoah Anders Berglund Ratna Chakrabarti Jong Y. Park |
| author_facet | Richard Ottman Kavya Ganapathy Hui-Yi Lin Carlos Diaz Osterman Julie Dutil Jaime Matta Gilberto Ruiz-Deya Liang Wang Kosj Yamoah Anders Berglund Ratna Chakrabarti Jong Y. Park |
| author_sort | Richard Ottman |
| collection | DOAJ |
| description | Prostate cancer is the leading cancer in incidence and second leading cause of cancer mortality in US men. African American men have significantly higher incidence and mortality rates from prostate cancer than European American men. Previous studies reported that the disparity in prostate cancer survival or mortality can be explained by different biological backgrounds. microRNAs (miRNAs) regulate gene expression of their cognate mRNAs in many cancers. Therefore, miRNAs may be a potentially promising diagnostic tool. The role of miRNAs in prostate cancer aggressiveness and racial disparity has not been fully established. The goal of this study is to identify miRNAs associated with aggressiveness and racial disparity in prostate cancer. Here we report miRNAs that are associated with tumor status and aggressiveness in prostate cancer using a profiling approach. Further, downregulated miRNAs in African American tissues were confirmed by qRT-PCR. These miRNAs have also been shown to negatively regulate the expression of the androgen receptor in prostate cancer cells. This report provides a novel insight into understanding tumor aggressiveness and racial disparities of prostate cancer. |
| first_indexed | 2024-03-11T05:09:52Z |
| format | Article |
| id | doaj.art-35e6166ef06e4e0698c870422dd3a43f |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T05:09:52Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-35e6166ef06e4e0698c870422dd3a43f2023-11-17T18:39:30ZengMDPI AGCancers2072-66942023-04-01158233110.3390/cancers15082331Differential Expression of miRNAs Contributes to Tumor Aggressiveness and Racial Disparity in African American Men with Prostate CancerRichard Ottman0Kavya Ganapathy1Hui-Yi Lin2Carlos Diaz Osterman3Julie Dutil4Jaime Matta5Gilberto Ruiz-Deya6Liang Wang7Kosj Yamoah8Anders Berglund9Ratna Chakrabarti10Jong Y. Park11Burnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USABurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USABiostatistics Program, School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USADepartment of Basic Sciences, Ponce Research Institute, School of Medicine, Ponce Health Sciences University, Ponce, PR 00716, USADepartment of Basic Sciences, Ponce Research Institute, School of Medicine, Ponce Health Sciences University, Ponce, PR 00716, USADepartment of Basic Sciences, Ponce Research Institute, School of Medicine, Ponce Health Sciences University, Ponce, PR 00716, USADepartment of Basic Sciences, Ponce Research Institute, School of Medicine, Ponce Health Sciences University, Ponce, PR 00716, USADepartment of Tumor Biology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Radiation Oncology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USADepartment of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USABurnett School of Biomedical Sciences, University of Central Florida, Orlando, FL 32816, USADepartment of Cancer Epidemiology, H. Lee Moffitt Cancer Center, Tampa, FL 33612, USAProstate cancer is the leading cancer in incidence and second leading cause of cancer mortality in US men. African American men have significantly higher incidence and mortality rates from prostate cancer than European American men. Previous studies reported that the disparity in prostate cancer survival or mortality can be explained by different biological backgrounds. microRNAs (miRNAs) regulate gene expression of their cognate mRNAs in many cancers. Therefore, miRNAs may be a potentially promising diagnostic tool. The role of miRNAs in prostate cancer aggressiveness and racial disparity has not been fully established. The goal of this study is to identify miRNAs associated with aggressiveness and racial disparity in prostate cancer. Here we report miRNAs that are associated with tumor status and aggressiveness in prostate cancer using a profiling approach. Further, downregulated miRNAs in African American tissues were confirmed by qRT-PCR. These miRNAs have also been shown to negatively regulate the expression of the androgen receptor in prostate cancer cells. This report provides a novel insight into understanding tumor aggressiveness and racial disparities of prostate cancer.https://www.mdpi.com/2072-6694/15/8/2331prostate cancermiRNAhealth disparityaggressiveness |
| spellingShingle | Richard Ottman Kavya Ganapathy Hui-Yi Lin Carlos Diaz Osterman Julie Dutil Jaime Matta Gilberto Ruiz-Deya Liang Wang Kosj Yamoah Anders Berglund Ratna Chakrabarti Jong Y. Park Differential Expression of miRNAs Contributes to Tumor Aggressiveness and Racial Disparity in African American Men with Prostate Cancer Cancers prostate cancer miRNA health disparity aggressiveness |
| title | Differential Expression of miRNAs Contributes to Tumor Aggressiveness and Racial Disparity in African American Men with Prostate Cancer |
| title_full | Differential Expression of miRNAs Contributes to Tumor Aggressiveness and Racial Disparity in African American Men with Prostate Cancer |
| title_fullStr | Differential Expression of miRNAs Contributes to Tumor Aggressiveness and Racial Disparity in African American Men with Prostate Cancer |
| title_full_unstemmed | Differential Expression of miRNAs Contributes to Tumor Aggressiveness and Racial Disparity in African American Men with Prostate Cancer |
| title_short | Differential Expression of miRNAs Contributes to Tumor Aggressiveness and Racial Disparity in African American Men with Prostate Cancer |
| title_sort | differential expression of mirnas contributes to tumor aggressiveness and racial disparity in african american men with prostate cancer |
| topic | prostate cancer miRNA health disparity aggressiveness |
| url | https://www.mdpi.com/2072-6694/15/8/2331 |
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