Enhancing response of a protein conformational switch by using two disordered ligand binding domains
Introduction: Protein conformational switches are often constructed by fusing an input domain, which recognizes a target ligand, to an output domain that establishes a biological response. Prior designs have employed binding-induced folding of the input domain to drive a conformational change in the...
Main Authors: | Harsimranjit Sekhon, Jeung-Hoi Ha, Stewart N. Loh |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2023-03-01
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Series: | Frontiers in Molecular Biosciences |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1114756/full |
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