SURVIVAL CURVE ANALYSIS FOR DROSOPHILA MELANOGASTER WITH D-GADD45 OVEREXPRESSION IN THE NERVOUS SYSTEM
Overexpression of the Gadd45 gene in the nervous system of Drosophila melanogaster increases the life span. We have performed the Gompertz approximation of the survival curve and revealed a life span increase as a result of decrease of the R parameter, reflecting the death level at the beginning of...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders
2015-01-01
|
| Series: | Вавиловский журнал генетики и селекции |
| Subjects: | |
| Online Access: | https://vavilov.elpub.ru/jour/article/view/162 |
| _version_ | 1797214208713031680 |
|---|---|
| author | E. N. Plyusnina M. V. Shaposhnikov E. N. Andreeva A. A. Moskalev L. V. Omelyanchuk |
| author_facet | E. N. Plyusnina M. V. Shaposhnikov E. N. Andreeva A. A. Moskalev L. V. Omelyanchuk |
| author_sort | E. N. Plyusnina |
| collection | DOAJ |
| description | Overexpression of the Gadd45 gene in the nervous system of Drosophila melanogaster increases the life span. We have performed the Gompertz approximation of the survival curve and revealed a life span increase as a result of decrease of the R parameter, reflecting the death level at the beginning of adult life, whereas the other Gompertz parameter, α, responsible for final stage of the life, does not change essentially. In addition, we have analyzed the case of radiation hormesis (low doses of radiation increase life span) and found a similar effect. We conclude that it is promising to perform geroprotector screen by testing substances for the ability to decrease R. Its measurement is less labor-consuming than the construction of the complete survival curve. |
| first_indexed | 2024-03-07T16:07:54Z |
| format | Article |
| id | doaj.art-35e86aa300af437eaebca120810a8088 |
| institution | Directory Open Access Journal |
| issn | 2500-3259 |
| language | English |
| last_indexed | 2024-04-24T11:10:31Z |
| publishDate | 2015-01-01 |
| publisher | Siberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and Breeders |
| record_format | Article |
| series | Вавиловский журнал генетики и селекции |
| spelling | doaj.art-35e86aa300af437eaebca120810a80882024-04-11T15:30:53ZengSiberian Branch of the Russian Academy of Sciences, Federal Research Center Institute of Cytology and Genetics, The Vavilov Society of Geneticists and BreedersВавиловский журнал генетики и селекции2500-32592015-01-01173399403146SURVIVAL CURVE ANALYSIS FOR DROSOPHILA MELANOGASTER WITH D-GADD45 OVEREXPRESSION IN THE NERVOUS SYSTEME. N. Plyusnina0M. V. Shaposhnikov1E. N. Andreeva2A. A. Moskalev3L. V. Omelyanchuk4Institute of Biоlogy, Komi Center of UB RAS, Syktivkar, Russia Syktivkar State University, RussiaInstitute of Biоlogy, Komi Center of UB RAS, Syktivkar, Russia Syktivkar State University, RussiaInstitute of Molecular and Cellular Biology SB RAS, Novosibirsk, RussiaInstitute of Biоlogy, Komi Center of UB RAS, Syktivkar, Russia Syktivkar State University, Russia Moscow Institute of Physics and Technology, RussiaInstitute of Molecular and Cellular Biology SB RAS, Novosibirsk, RussiaOverexpression of the Gadd45 gene in the nervous system of Drosophila melanogaster increases the life span. We have performed the Gompertz approximation of the survival curve and revealed a life span increase as a result of decrease of the R parameter, reflecting the death level at the beginning of adult life, whereas the other Gompertz parameter, α, responsible for final stage of the life, does not change essentially. In addition, we have analyzed the case of radiation hormesis (low doses of radiation increase life span) and found a similar effect. We conclude that it is promising to perform geroprotector screen by testing substances for the ability to decrease R. Its measurement is less labor-consuming than the construction of the complete survival curve.https://vavilov.elpub.ru/jour/article/view/162longevitydna repairgadd45overexpressionlow radiation doseshormesisdrosophila melanogaster |
| spellingShingle | E. N. Plyusnina M. V. Shaposhnikov E. N. Andreeva A. A. Moskalev L. V. Omelyanchuk SURVIVAL CURVE ANALYSIS FOR DROSOPHILA MELANOGASTER WITH D-GADD45 OVEREXPRESSION IN THE NERVOUS SYSTEM Вавиловский журнал генетики и селекции longevity dna repair gadd45 overexpression low radiation doses hormesis drosophila melanogaster |
| title | SURVIVAL CURVE ANALYSIS FOR DROSOPHILA MELANOGASTER WITH D-GADD45 OVEREXPRESSION IN THE NERVOUS SYSTEM |
| title_full | SURVIVAL CURVE ANALYSIS FOR DROSOPHILA MELANOGASTER WITH D-GADD45 OVEREXPRESSION IN THE NERVOUS SYSTEM |
| title_fullStr | SURVIVAL CURVE ANALYSIS FOR DROSOPHILA MELANOGASTER WITH D-GADD45 OVEREXPRESSION IN THE NERVOUS SYSTEM |
| title_full_unstemmed | SURVIVAL CURVE ANALYSIS FOR DROSOPHILA MELANOGASTER WITH D-GADD45 OVEREXPRESSION IN THE NERVOUS SYSTEM |
| title_short | SURVIVAL CURVE ANALYSIS FOR DROSOPHILA MELANOGASTER WITH D-GADD45 OVEREXPRESSION IN THE NERVOUS SYSTEM |
| title_sort | survival curve analysis for drosophila melanogaster with d gadd45 overexpression in the nervous system |
| topic | longevity dna repair gadd45 overexpression low radiation doses hormesis drosophila melanogaster |
| url | https://vavilov.elpub.ru/jour/article/view/162 |
| work_keys_str_mv | AT enplyusnina survivalcurveanalysisfordrosophilamelanogasterwithdgadd45overexpressioninthenervoussystem AT mvshaposhnikov survivalcurveanalysisfordrosophilamelanogasterwithdgadd45overexpressioninthenervoussystem AT enandreeva survivalcurveanalysisfordrosophilamelanogasterwithdgadd45overexpressioninthenervoussystem AT aamoskalev survivalcurveanalysisfordrosophilamelanogasterwithdgadd45overexpressioninthenervoussystem AT lvomelyanchuk survivalcurveanalysisfordrosophilamelanogasterwithdgadd45overexpressioninthenervoussystem |