The interplay between non-alcoholic fatty liver disease and innate immunity in hepatitis B virus patients
Abstract Background Non-alcoholic fatty liver disease (NAFLD) is the most epidemic liver disorder worldwide as a result of rapid lifestyle transformation over the past few decades and is expected to elevate in the next few years as well as it is ranging from plain hepatic steatosis via non-alcoholic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2021-03-01
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| Series: | Egyptian Liver Journal |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s43066-021-00084-w |
| _version_ | 1818336830069669888 |
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| author | Fayed Attia Koutb Megahed Xiaoling Zhou Pingnan Sun Marwa Mohamed Elmaghrabi |
| author_facet | Fayed Attia Koutb Megahed Xiaoling Zhou Pingnan Sun Marwa Mohamed Elmaghrabi |
| author_sort | Fayed Attia Koutb Megahed |
| collection | DOAJ |
| description | Abstract Background Non-alcoholic fatty liver disease (NAFLD) is the most epidemic liver disorder worldwide as a result of rapid lifestyle transformation over the past few decades and is expected to elevate in the next few years as well as it is ranging from plain hepatic steatosis via non-alcoholic steatohepatitis (NASH) to liver cirrhosis and hepatocellular carcinoma (HCC). Main text NAFLD can also stimulate the diseases progression as diabetes and cardiovascular. Therefore, understanding the NAFLD pathogenesis is of vital clinical interest additionally is a crucial for disease treatment and prevention. After analyzing NAFLD and liver diseases prevalence, it has been a belief regarding the interaction between NAFLD and chronic hepatitis B (CHB). Conclusion The liver is an essential innate immune organ with large numbers of innate immune cells that contribute in NAFLD pathogenesis, additionally play the influential role that control NAFLD progression in the hepatitis B patients. Here, we summarized the recent advances in understanding and managing the NAFLD patients with chronic hepatitis B infection and interplay with innate immunity. |
| first_indexed | 2024-12-13T14:45:33Z |
| format | Article |
| id | doaj.art-35e89a8f84824935a464f9b7662cef4b |
| institution | Directory Open Access Journal |
| issn | 2090-6226 |
| language | English |
| last_indexed | 2024-12-13T14:45:33Z |
| publishDate | 2021-03-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Egyptian Liver Journal |
| spelling | doaj.art-35e89a8f84824935a464f9b7662cef4b2022-12-21T23:41:29ZengSpringerOpenEgyptian Liver Journal2090-62262021-03-0111111110.1186/s43066-021-00084-wThe interplay between non-alcoholic fatty liver disease and innate immunity in hepatitis B virus patientsFayed Attia Koutb Megahed0Xiaoling Zhou1Pingnan Sun2Marwa Mohamed Elmaghrabi3Stem Cell Research Center, Research Center for Reproductive Medicine, Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical CollegeStem Cell Research Center, Research Center for Reproductive Medicine, Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical CollegeStem Cell Research Center, Research Center for Reproductive Medicine, Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology, Shantou University Medical CollegeCenter of Excellence for Research in Regenerative Medicine and Applications, Faculty of Medicine, Alexandria UniversityAbstract Background Non-alcoholic fatty liver disease (NAFLD) is the most epidemic liver disorder worldwide as a result of rapid lifestyle transformation over the past few decades and is expected to elevate in the next few years as well as it is ranging from plain hepatic steatosis via non-alcoholic steatohepatitis (NASH) to liver cirrhosis and hepatocellular carcinoma (HCC). Main text NAFLD can also stimulate the diseases progression as diabetes and cardiovascular. Therefore, understanding the NAFLD pathogenesis is of vital clinical interest additionally is a crucial for disease treatment and prevention. After analyzing NAFLD and liver diseases prevalence, it has been a belief regarding the interaction between NAFLD and chronic hepatitis B (CHB). Conclusion The liver is an essential innate immune organ with large numbers of innate immune cells that contribute in NAFLD pathogenesis, additionally play the influential role that control NAFLD progression in the hepatitis B patients. Here, we summarized the recent advances in understanding and managing the NAFLD patients with chronic hepatitis B infection and interplay with innate immunity.https://doi.org/10.1186/s43066-021-00084-wHBVFatty liverNAFLDNASHInnate immunity |
| spellingShingle | Fayed Attia Koutb Megahed Xiaoling Zhou Pingnan Sun Marwa Mohamed Elmaghrabi The interplay between non-alcoholic fatty liver disease and innate immunity in hepatitis B virus patients Egyptian Liver Journal HBV Fatty liver NAFLD NASH Innate immunity |
| title | The interplay between non-alcoholic fatty liver disease and innate immunity in hepatitis B virus patients |
| title_full | The interplay between non-alcoholic fatty liver disease and innate immunity in hepatitis B virus patients |
| title_fullStr | The interplay between non-alcoholic fatty liver disease and innate immunity in hepatitis B virus patients |
| title_full_unstemmed | The interplay between non-alcoholic fatty liver disease and innate immunity in hepatitis B virus patients |
| title_short | The interplay between non-alcoholic fatty liver disease and innate immunity in hepatitis B virus patients |
| title_sort | interplay between non alcoholic fatty liver disease and innate immunity in hepatitis b virus patients |
| topic | HBV Fatty liver NAFLD NASH Innate immunity |
| url | https://doi.org/10.1186/s43066-021-00084-w |
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