Intraparenchymal Hemorrhage due to Brain Metastasis of Hepatocellular Carcinoma
Although extrahepatic metastases from hepatocellular carcinoma (HCC) are present in only 5–15% of cases, they are certainly factors associated with poor prognosis. The main sites include lung, lymph nodes, bones, and adrenal glands, in descending order. Metastasis in the central nervous system is ex...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2017-09-01
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| Series: | Case Reports in Gastroenterology |
| Subjects: | |
| Online Access: | http://www.karger.com/Article/FullText/479221 |
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| author | Rafael Sartori Balbinot Ana Laura Facco Muscope Mateus Dal Castel Silvana Sartori Balbinot Raul Angelo Balbinot Jonathan Soldera |
| author_facet | Rafael Sartori Balbinot Ana Laura Facco Muscope Mateus Dal Castel Silvana Sartori Balbinot Raul Angelo Balbinot Jonathan Soldera |
| author_sort | Rafael Sartori Balbinot |
| collection | DOAJ |
| description | Although extrahepatic metastases from hepatocellular carcinoma (HCC) are present in only 5–15% of cases, they are certainly factors associated with poor prognosis. The main sites include lung, lymph nodes, bones, and adrenal glands, in descending order. Metastasis in the central nervous system is extremely rare, and the incidences vary from 0.6 to 1.7%. We report a case of a 54-year-old man previously diagnosed with alcohol-induced cirrhosis of the liver and HCC. The patient was admitted presenting progressive left hemiparesis and headache which started 2 days earlier, with no history of cranioencephalic trauma. After admission, cranial computed tomography revealed an intraparenchymal hemorrhage area with surrounding edema in the right frontal lobe. An angioresonance requested showed a large extra-axial mass lesion located in the right frontal region with well-defined contours and predominantly hypointense signal on T2 sequence. At first, the radiological findings suggested meningioma as the first diagnostic hypothesis. However, the patient underwent surgery. The tumor was completely removed, and the morphological and immunohistochemical findings were consistent with metastatic hepatocarcinoma associated with meningioma. In postoperative care, the patient did not recover from the left hemiparesis and manifested Broca’s aphasia. He had a survival time of 24 weeks, presenting acute liver failure as his cause of death. There is a lack of evidence supporting a specific management of patients with brain metastasis from HCC. Furthermore, there are no studies that evaluate different modalities of therapeutics in brain metastasis of HCC due to the rarity of this condition. Therefore, management must be individualized depending on probable prognostic factors in these patients. |
| first_indexed | 2024-12-11T22:30:58Z |
| format | Article |
| id | doaj.art-35e8ad4f1abd4692852e7e3edf1d3636 |
| institution | Directory Open Access Journal |
| issn | 1662-0631 |
| language | English |
| last_indexed | 2024-12-11T22:30:58Z |
| publishDate | 2017-09-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Gastroenterology |
| spelling | doaj.art-35e8ad4f1abd4692852e7e3edf1d36362022-12-22T00:48:08ZengKarger PublishersCase Reports in Gastroenterology1662-06312017-09-0111351652510.1159/000479221479221Intraparenchymal Hemorrhage due to Brain Metastasis of Hepatocellular CarcinomaRafael Sartori BalbinotAna Laura Facco MuscopeMateus Dal CastelSilvana Sartori BalbinotRaul Angelo BalbinotJonathan SolderaAlthough extrahepatic metastases from hepatocellular carcinoma (HCC) are present in only 5–15% of cases, they are certainly factors associated with poor prognosis. The main sites include lung, lymph nodes, bones, and adrenal glands, in descending order. Metastasis in the central nervous system is extremely rare, and the incidences vary from 0.6 to 1.7%. We report a case of a 54-year-old man previously diagnosed with alcohol-induced cirrhosis of the liver and HCC. The patient was admitted presenting progressive left hemiparesis and headache which started 2 days earlier, with no history of cranioencephalic trauma. After admission, cranial computed tomography revealed an intraparenchymal hemorrhage area with surrounding edema in the right frontal lobe. An angioresonance requested showed a large extra-axial mass lesion located in the right frontal region with well-defined contours and predominantly hypointense signal on T2 sequence. At first, the radiological findings suggested meningioma as the first diagnostic hypothesis. However, the patient underwent surgery. The tumor was completely removed, and the morphological and immunohistochemical findings were consistent with metastatic hepatocarcinoma associated with meningioma. In postoperative care, the patient did not recover from the left hemiparesis and manifested Broca’s aphasia. He had a survival time of 24 weeks, presenting acute liver failure as his cause of death. There is a lack of evidence supporting a specific management of patients with brain metastasis from HCC. Furthermore, there are no studies that evaluate different modalities of therapeutics in brain metastasis of HCC due to the rarity of this condition. Therefore, management must be individualized depending on probable prognostic factors in these patients.http://www.karger.com/Article/FullText/479221Hepatocellular carcinomaBrain metastasisIntraparenchymal hemorrhage |
| spellingShingle | Rafael Sartori Balbinot Ana Laura Facco Muscope Mateus Dal Castel Silvana Sartori Balbinot Raul Angelo Balbinot Jonathan Soldera Intraparenchymal Hemorrhage due to Brain Metastasis of Hepatocellular Carcinoma Case Reports in Gastroenterology Hepatocellular carcinoma Brain metastasis Intraparenchymal hemorrhage |
| title | Intraparenchymal Hemorrhage due to Brain Metastasis of Hepatocellular Carcinoma |
| title_full | Intraparenchymal Hemorrhage due to Brain Metastasis of Hepatocellular Carcinoma |
| title_fullStr | Intraparenchymal Hemorrhage due to Brain Metastasis of Hepatocellular Carcinoma |
| title_full_unstemmed | Intraparenchymal Hemorrhage due to Brain Metastasis of Hepatocellular Carcinoma |
| title_short | Intraparenchymal Hemorrhage due to Brain Metastasis of Hepatocellular Carcinoma |
| title_sort | intraparenchymal hemorrhage due to brain metastasis of hepatocellular carcinoma |
| topic | Hepatocellular carcinoma Brain metastasis Intraparenchymal hemorrhage |
| url | http://www.karger.com/Article/FullText/479221 |
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