Markedly elevated lipase as the first manifestation of celiac disease: Case Report

Lipase is a hydrolytic enzyme and commonly used for the diagnosis of pancreatitis with amylase. Except for pancreatitis, lipase is elevated in many clinical conditions such as hepatobiliary disorders, bowel diseases, malignancies, renal impairment. Celiac disease (CD) should be considered as one of...

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Bibliographic Details
Main Authors: Fazıl Hunutlu, Macit Gülten, Ahmet Bilgehan Şahin, Nesrin Uğraş
Format: Article
Language:English
Published: Nizameddin KOCA 2021-04-01
Series:Turkish Journal of Internal Medicine
Subjects:
Online Access:https://dergipark.org.tr/tr/download/article-file/1358386
Description
Summary:Lipase is a hydrolytic enzyme and commonly used for the diagnosis of pancreatitis with amylase. Except for pancreatitis, lipase is elevated in many clinical conditions such as hepatobiliary disorders, bowel diseases, malignancies, renal impairment. Celiac disease (CD) should be considered as one of the causes. In patients with CD, the frequency of pancreatic hyperenzymemia and possible pathophysiological mechanisms are not well studied. To date, several mechanisms explaining pancreatic hyperenzymemia in CD are reported. Malnutrition, disease bowel induced pancreatic dysfunction, autoimmune pancreatic inflammation, and macroenzymemia are the main ones. Herein, we report a patient with newly diagnosed CD, representing markedly elevated serum lipase level with normal amylase.
ISSN:2687-4245