Electrochemical behavior of lansoprazole at a multiwalled carbon nanotubes-ionic liquid modified glassy carbon electrode and its electrochemical determination
The electrochemical behavior of lansoprazole (LNS) has been investigated at a glassy carbon electrode (GCE) and the electrode modified by a gel containing multiwalled carbon nanotubes (MWCNTs) and an room-temperature ionic liquid (RTIL) of 1-Butyl-3-methylimidazolium hexafluorophosphate (BM...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Serbian Chemical Society
2014-01-01
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| Series: | Journal of the Serbian Chemical Society |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0352-5139/2014/0352-51391300059L.pdf |
| Summary: | The electrochemical behavior of lansoprazole (LNS) has been investigated at a
glassy carbon electrode (GCE) and the electrode modified by a gel containing
multiwalled carbon nanotubes (MWCNTs) and an room-temperature ionic liquid
(RTIL) of 1-Butyl-3-methylimidazolium hexafluorophosphate (BMIMPF6) in 0.10
M phosphate buffer solution of pH 6.8. It was found that an irreversible
anodic oxidation peak with Epa as 1.060 V appeared at MWCNTs-RTIL/GCE. Under
the optimized experimental conditions a linear calibration curve were
obtained over the concentration range from 5.0 μM to 0.20 mM by differential
pulse voltammetry with the limit of detection (LOD, S/N = 3) as 0.28 μM. In
addition, the novel MWCNTs-RTIL/GCE was also characterized by the
electrochemical impedance spectroscopy and the proposed method has been
successfully applied in the electrochemical quantitative determination of
LNS content in commercial tablet samples and the determination results could
meet the determination requirement. |
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| ISSN: | 0352-5139 1820-7421 |