Utility of Direct Coomb’s test in a Tertiary Care Nursery
Objective: To document the causes and clinical significance of direct Coomb’s test distal convoluted tubule in neonatal Jaundice at a tertiary care setup. Study Design: Cross-sectional study. Place and Duration of the Study: Fatima Memorial Hospital, Lahore Pakistan, from Nov 2019 to Oct 2020...
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| Format: | Article |
| Language: | English |
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Army Medical College Rawalpindi
2023-06-01
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| Series: | Pakistan Armed Forces Medical Journal |
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| Online Access: | https://www.pafmj.org/index.php/PAFMJ/article/view/7640 |
| _version_ | 1797690124405833728 |
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| author | Mussab Ahmed Zahid Anwar Rafia Gul Tahreem Munir Furqan Saleem Saima Pirzada |
| author_facet | Mussab Ahmed Zahid Anwar Rafia Gul Tahreem Munir Furqan Saleem Saima Pirzada |
| author_sort | Mussab Ahmed |
| collection | DOAJ |
| description |
Objective: To document the causes and clinical significance of direct Coomb’s test distal convoluted tubule in neonatal Jaundice at a tertiary care setup.
Study Design: Cross-sectional study.
Place and Duration of the Study: Fatima Memorial Hospital, Lahore Pakistan, from Nov 2019 to Oct 2020.
Methodology: All babies born to “O” or Rh-negative blood group mothers were included. In addition, data including demographics, mother’s blood group, baby’s blood group, direct Coomb’s test results, bilirubin values, and need for treatment was recorded.
Results: The study included 989 neonates. Of all, 489(49.4%) were male, the mean birth weight was 2.80±0.75 kg, and the mean gestation was 36±4.3 weeks. ABO mismatch was present in 452(45.7%) cases and Rh mismatch in 123(12.4%). Of all, 58(5.9%) had positive direct Coomb’s test. Amongst the positive direct Coomb’s test patients, 44(75.8%) babies needed treatment, of which 40(90.9%) received phototherapy, and 4(6.8%) needed Intensive phototherapy (360 degrees). No baby needed an exchange transfusion.
Conclusion: In most cases, positive direct Coomb’s test was due to ABO blood group incompatibility. In addition, early phototherapy can control bilirubin rise in most cases, so few would need aggressive or intensive treatment.
Keywords: ABO mismatch, Direct Coomb’s test, Neonatal jaundice, Rh mismatch.
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| first_indexed | 2024-03-12T01:55:04Z |
| format | Article |
| id | doaj.art-35ea6e73fdd94270a2ef6615a71468a4 |
| institution | Directory Open Access Journal |
| issn | 0030-9648 2411-8842 |
| language | English |
| last_indexed | 2024-03-12T01:55:04Z |
| publishDate | 2023-06-01 |
| publisher | Army Medical College Rawalpindi |
| record_format | Article |
| series | Pakistan Armed Forces Medical Journal |
| spelling | doaj.art-35ea6e73fdd94270a2ef6615a71468a42023-09-08T06:02:43ZengArmy Medical College RawalpindiPakistan Armed Forces Medical Journal0030-96482411-88422023-06-0173310.51253/pafmj.v73i3.7640Utility of Direct Coomb’s test in a Tertiary Care NurseryMussab Ahmed0Zahid Anwar1Rafia Gul2Tahreem Munir3Furqan Saleem4Saima Pirzada5Department of Neonatology, Fatima Memorial Hospital, Lahore PakistanDepartment of Neonatology, Fatima Memorial Hospital, Lahore PakistanDepartment of Neonatology, Fatima Memorial Hospital, Lahore PakistanDepartment of Anesthesia, Mayo Hospital, Lahore PakistanDepartment of Neonatology, Fatima Memorial Hospital, Lahore PakistanDepartment of Neonatology, Fatima Memorial Hospital, Lahore Pakistan Objective: To document the causes and clinical significance of direct Coomb’s test distal convoluted tubule in neonatal Jaundice at a tertiary care setup. Study Design: Cross-sectional study. Place and Duration of the Study: Fatima Memorial Hospital, Lahore Pakistan, from Nov 2019 to Oct 2020. Methodology: All babies born to “O” or Rh-negative blood group mothers were included. In addition, data including demographics, mother’s blood group, baby’s blood group, direct Coomb’s test results, bilirubin values, and need for treatment was recorded. Results: The study included 989 neonates. Of all, 489(49.4%) were male, the mean birth weight was 2.80±0.75 kg, and the mean gestation was 36±4.3 weeks. ABO mismatch was present in 452(45.7%) cases and Rh mismatch in 123(12.4%). Of all, 58(5.9%) had positive direct Coomb’s test. Amongst the positive direct Coomb’s test patients, 44(75.8%) babies needed treatment, of which 40(90.9%) received phototherapy, and 4(6.8%) needed Intensive phototherapy (360 degrees). No baby needed an exchange transfusion. Conclusion: In most cases, positive direct Coomb’s test was due to ABO blood group incompatibility. In addition, early phototherapy can control bilirubin rise in most cases, so few would need aggressive or intensive treatment. Keywords: ABO mismatch, Direct Coomb’s test, Neonatal jaundice, Rh mismatch. https://www.pafmj.org/index.php/PAFMJ/article/view/7640ABO mismatchDirect Coomb’s testNeonatal jaundiceRh mismatch |
| spellingShingle | Mussab Ahmed Zahid Anwar Rafia Gul Tahreem Munir Furqan Saleem Saima Pirzada Utility of Direct Coomb’s test in a Tertiary Care Nursery Pakistan Armed Forces Medical Journal ABO mismatch Direct Coomb’s test Neonatal jaundice Rh mismatch |
| title | Utility of Direct Coomb’s test in a Tertiary Care Nursery |
| title_full | Utility of Direct Coomb’s test in a Tertiary Care Nursery |
| title_fullStr | Utility of Direct Coomb’s test in a Tertiary Care Nursery |
| title_full_unstemmed | Utility of Direct Coomb’s test in a Tertiary Care Nursery |
| title_short | Utility of Direct Coomb’s test in a Tertiary Care Nursery |
| title_sort | utility of direct coomb s test in a tertiary care nursery |
| topic | ABO mismatch Direct Coomb’s test Neonatal jaundice Rh mismatch |
| url | https://www.pafmj.org/index.php/PAFMJ/article/view/7640 |
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