Self-assembled core-shell nanoparticles with embedded internal standards for SERS quantitative detection and identification of nicotine released from snus products
Surface enhanced Raman spectroscopy (SERS) is a unique analytical technique with excellent performance in terms of sensitivity, non-destructive detection and resolution. However, due to the randomness and poor repeatability of hot spot distribution, SERS quantitative analysis is still challenging. M...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Chemistry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fchem.2024.1348423/full |
| _version_ | 1797242600632090624 |
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| author | Yongfeng Tian Yongfeng Tian Lu Zhao Xiaofeng Shen Shanzhai Shang Yonghua Pan Gaofeng Dong Wang Huo Donglai Zhu Xianghu Tang |
| author_facet | Yongfeng Tian Yongfeng Tian Lu Zhao Xiaofeng Shen Shanzhai Shang Yonghua Pan Gaofeng Dong Wang Huo Donglai Zhu Xianghu Tang |
| author_sort | Yongfeng Tian |
| collection | DOAJ |
| description | Surface enhanced Raman spectroscopy (SERS) is a unique analytical technique with excellent performance in terms of sensitivity, non-destructive detection and resolution. However, due to the randomness and poor repeatability of hot spot distribution, SERS quantitative analysis is still challenging. Meanwhile, snus is a type of tobacco product that can release nicotine and other components in the mouth without burning, and the rapid detection technique based on SERS can reliably evaluate the amount of nicotine released from snus, which is of great significance for understanding its characteristics and regulating its components. Herein, the strategy was proposed to solve the feasibility of SERS quantitative detection based on self-assembled core-shell nanoparticles with embedded internal standards (EIS) due to EIS signal can effectively correct SERS signal fluctuations caused by different aggregation states and measurement conditions, thus allowing reliable quantitative SERS analysis of targets with different surface affinity. By means of process control, after the Au nanoparticles (Au NPs) were modified with 4-Mercaptobenzonitrile (4-MBN) as internal standard molecules, Ag shell with a certain thickness was grown on the surface of the AuNP@4-MBN, and then the Au@4-MBN@Ag NPs were used to regulate and control the assembly of liquid-liquid interface. The high-density nano-arrays assembled at the liquid-liquid interface ensure high reproducibility as SERS substrates, and which could be used for SERS detection of nicotine released from snus products. In addition, time-mapping research shows that this method can also be used to dynamically monitor the release of nicotine. Moreover, such destruction-free evaluation of the release of nicotine from snus products opens up new perspectives for further research about the impact of nicotinoids-related health programs. |
| first_indexed | 2024-04-24T18:41:48Z |
| format | Article |
| id | doaj.art-35ea70cadef347b682853474f4a5a047 |
| institution | Directory Open Access Journal |
| issn | 2296-2646 |
| language | English |
| last_indexed | 2024-04-24T18:41:48Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Chemistry |
| spelling | doaj.art-35ea70cadef347b682853474f4a5a0472024-03-27T10:37:05ZengFrontiers Media S.A.Frontiers in Chemistry2296-26462024-03-011210.3389/fchem.2024.13484231348423Self-assembled core-shell nanoparticles with embedded internal standards for SERS quantitative detection and identification of nicotine released from snus productsYongfeng Tian0Yongfeng Tian1Lu Zhao2Xiaofeng Shen3Shanzhai Shang4Yonghua Pan5Gaofeng Dong6Wang Huo7Donglai Zhu8Xianghu Tang9Technology Center of China Tobacco Yunnan Industrial Co., Ltd., Kunming, ChinaAnhui Institute of Optics and Fine Mechanics, HFIPS, Chinese Academy of Sciences, Hefei, ChinaYunnan Academy of Tobacco Agricultural Sciences, Kunming, ChinaTechnology Center of China Tobacco Yunnan Industrial Co., Ltd., Kunming, ChinaTechnology Center of China Tobacco Yunnan Industrial Co., Ltd., Kunming, ChinaHongta Tobacco (Group) Co., Ltd., Yuxi, ChinaTechnology Center of China Tobacco Yunnan Industrial Co., Ltd., Kunming, ChinaInstitute of Solid State Physics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, ChinaTechnology Center of China Tobacco Yunnan Industrial Co., Ltd., Kunming, ChinaInstitute of Solid State Physics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, ChinaSurface enhanced Raman spectroscopy (SERS) is a unique analytical technique with excellent performance in terms of sensitivity, non-destructive detection and resolution. However, due to the randomness and poor repeatability of hot spot distribution, SERS quantitative analysis is still challenging. Meanwhile, snus is a type of tobacco product that can release nicotine and other components in the mouth without burning, and the rapid detection technique based on SERS can reliably evaluate the amount of nicotine released from snus, which is of great significance for understanding its characteristics and regulating its components. Herein, the strategy was proposed to solve the feasibility of SERS quantitative detection based on self-assembled core-shell nanoparticles with embedded internal standards (EIS) due to EIS signal can effectively correct SERS signal fluctuations caused by different aggregation states and measurement conditions, thus allowing reliable quantitative SERS analysis of targets with different surface affinity. By means of process control, after the Au nanoparticles (Au NPs) were modified with 4-Mercaptobenzonitrile (4-MBN) as internal standard molecules, Ag shell with a certain thickness was grown on the surface of the AuNP@4-MBN, and then the Au@4-MBN@Ag NPs were used to regulate and control the assembly of liquid-liquid interface. The high-density nano-arrays assembled at the liquid-liquid interface ensure high reproducibility as SERS substrates, and which could be used for SERS detection of nicotine released from snus products. In addition, time-mapping research shows that this method can also be used to dynamically monitor the release of nicotine. Moreover, such destruction-free evaluation of the release of nicotine from snus products opens up new perspectives for further research about the impact of nicotinoids-related health programs.https://www.frontiersin.org/articles/10.3389/fchem.2024.1348423/fullnicotinesnusSERS (surface enhanced Raman spectroscopy)internal standardsliquid-liquid interface |
| spellingShingle | Yongfeng Tian Yongfeng Tian Lu Zhao Xiaofeng Shen Shanzhai Shang Yonghua Pan Gaofeng Dong Wang Huo Donglai Zhu Xianghu Tang Self-assembled core-shell nanoparticles with embedded internal standards for SERS quantitative detection and identification of nicotine released from snus products Frontiers in Chemistry nicotine snus SERS (surface enhanced Raman spectroscopy) internal standards liquid-liquid interface |
| title | Self-assembled core-shell nanoparticles with embedded internal standards for SERS quantitative detection and identification of nicotine released from snus products |
| title_full | Self-assembled core-shell nanoparticles with embedded internal standards for SERS quantitative detection and identification of nicotine released from snus products |
| title_fullStr | Self-assembled core-shell nanoparticles with embedded internal standards for SERS quantitative detection and identification of nicotine released from snus products |
| title_full_unstemmed | Self-assembled core-shell nanoparticles with embedded internal standards for SERS quantitative detection and identification of nicotine released from snus products |
| title_short | Self-assembled core-shell nanoparticles with embedded internal standards for SERS quantitative detection and identification of nicotine released from snus products |
| title_sort | self assembled core shell nanoparticles with embedded internal standards for sers quantitative detection and identification of nicotine released from snus products |
| topic | nicotine snus SERS (surface enhanced Raman spectroscopy) internal standards liquid-liquid interface |
| url | https://www.frontiersin.org/articles/10.3389/fchem.2024.1348423/full |
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