Hyperuricemia remodels the serum proteome toward a higher inflammatory state
Summary: Gout is an autoinflammatory disease triggered by a complex innate immune response to MSU crystals and inflammatory triggers. While hyperuricemia is an obligatory risk factor for the development of gout, the majority of individuals with hyperuricemia never develop gout but have an increased...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | iScience |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2589004223019867 |
| _version_ | 1797647809138130944 |
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| author | Georgiana Cabău Orsolya Gaal Medeea Badii Valentin Nica Andreea-Manuela Mirea Ioana Hotea Cristina Pamfil Radu A. Popp Mihai G. Netea Simona Rednic Tania O. Crișan Leo A.B. Joosten |
| author_facet | Georgiana Cabău Orsolya Gaal Medeea Badii Valentin Nica Andreea-Manuela Mirea Ioana Hotea Cristina Pamfil Radu A. Popp Mihai G. Netea Simona Rednic Tania O. Crișan Leo A.B. Joosten |
| author_sort | Georgiana Cabău |
| collection | DOAJ |
| description | Summary: Gout is an autoinflammatory disease triggered by a complex innate immune response to MSU crystals and inflammatory triggers. While hyperuricemia is an obligatory risk factor for the development of gout, the majority of individuals with hyperuricemia never develop gout but have an increased risk of developing cardiometabolic disorders. Current management of gout aims at MSU crystal dissolution by lowering serum urate. We apply a targeted proteomic analysis, using Olink inflammation panel, to a large group of individuals with gout, asymptomatic hyperuricemia, and normouricemic controls, and we show a urate-driven inflammatory signature. We add in vivo evidence of persistent immune activation linked to urate exposure and describe immune pathways involved in the pathogenesis of gout. Our results support a pro-inflammatory effect of asymptomatic hyperuricemia and pave the way for new research into targetable mechanisms in gout and cardiometabolic complications of asymptomatic hyperuricemia. |
| first_indexed | 2024-03-11T15:22:58Z |
| format | Article |
| id | doaj.art-35ea8c8f24f54204ba68c7a8604f1c7b |
| institution | Directory Open Access Journal |
| issn | 2589-0042 |
| language | English |
| last_indexed | 2024-03-11T15:22:58Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | iScience |
| spelling | doaj.art-35ea8c8f24f54204ba68c7a8604f1c7b2023-10-28T05:08:56ZengElsevieriScience2589-00422023-10-012610107909Hyperuricemia remodels the serum proteome toward a higher inflammatory stateGeorgiana Cabău0Orsolya Gaal1Medeea Badii2Valentin Nica3Andreea-Manuela Mirea4Ioana Hotea5Cristina Pamfil6Radu A. Popp7Mihai G. Netea8Simona Rednic9Tania O. Crișan10Leo A.B. Joosten11Department of Medical Genetics, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Medical Genetics, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Internal Medicine, Radboudumc, Nijmegen, the NetherlandsDepartment of Medical Genetics, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Internal Medicine, Radboudumc, Nijmegen, the NetherlandsDepartment of Medical Genetics, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Internal Medicine, Radboudumc, Nijmegen, the NetherlandsDepartment of Rheumatology, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Rheumatology, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Medical Genetics, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Internal Medicine, Radboudumc, Nijmegen, the Netherlands; Department of Immunology and Metabolism, Life and Medical Sciences Institute, University of Bonn, Bonn, GermanyDepartment of Rheumatology, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, RomaniaDepartment of Medical Genetics, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Internal Medicine, Radboudumc, Nijmegen, the NetherlandsDepartment of Medical Genetics, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Internal Medicine, Radboudumc, Nijmegen, the Netherlands; Corresponding authorSummary: Gout is an autoinflammatory disease triggered by a complex innate immune response to MSU crystals and inflammatory triggers. While hyperuricemia is an obligatory risk factor for the development of gout, the majority of individuals with hyperuricemia never develop gout but have an increased risk of developing cardiometabolic disorders. Current management of gout aims at MSU crystal dissolution by lowering serum urate. We apply a targeted proteomic analysis, using Olink inflammation panel, to a large group of individuals with gout, asymptomatic hyperuricemia, and normouricemic controls, and we show a urate-driven inflammatory signature. We add in vivo evidence of persistent immune activation linked to urate exposure and describe immune pathways involved in the pathogenesis of gout. Our results support a pro-inflammatory effect of asymptomatic hyperuricemia and pave the way for new research into targetable mechanisms in gout and cardiometabolic complications of asymptomatic hyperuricemia.http://www.sciencedirect.com/science/article/pii/S2589004223019867DiseaseHealth sciencesProteomics |
| spellingShingle | Georgiana Cabău Orsolya Gaal Medeea Badii Valentin Nica Andreea-Manuela Mirea Ioana Hotea Cristina Pamfil Radu A. Popp Mihai G. Netea Simona Rednic Tania O. Crișan Leo A.B. Joosten Hyperuricemia remodels the serum proteome toward a higher inflammatory state iScience Disease Health sciences Proteomics |
| title | Hyperuricemia remodels the serum proteome toward a higher inflammatory state |
| title_full | Hyperuricemia remodels the serum proteome toward a higher inflammatory state |
| title_fullStr | Hyperuricemia remodels the serum proteome toward a higher inflammatory state |
| title_full_unstemmed | Hyperuricemia remodels the serum proteome toward a higher inflammatory state |
| title_short | Hyperuricemia remodels the serum proteome toward a higher inflammatory state |
| title_sort | hyperuricemia remodels the serum proteome toward a higher inflammatory state |
| topic | Disease Health sciences Proteomics |
| url | http://www.sciencedirect.com/science/article/pii/S2589004223019867 |
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