Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and Analgesia
Introduction: Midazolam has turned into a common drug for pediatric procedural sedation and analgesia. However, there is not much data regarding its proper dose and potential side effects in the Iranian children population. Therefore, the present study was done to compare 2 doses of IV midazolam...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Shahid Beheshti University of Medical Sciences
2018-12-01
|
| Series: | Archives of Academic Emergency Medicine |
| Subjects: | |
| Online Access: | https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/249 |
| _version_ | 1798044161643905024 |
|---|---|
| author | Hassan Barzegari Arash Forouzan Kambiz Masoumi Hassan Motamed Behzad Zohrevandi Shima Zeynadini Meymand |
| author_facet | Hassan Barzegari Arash Forouzan Kambiz Masoumi Hassan Motamed Behzad Zohrevandi Shima Zeynadini Meymand |
| author_sort | Hassan Barzegari |
| collection | DOAJ |
| description | Introduction: Midazolam has turned into a common drug for pediatric procedural sedation and analgesia. However, there is not much data regarding its proper dose and potential side effects in the Iranian children population. Therefore, the present study was done to compare 2 doses of IV midazolam in this regard. Methods: The present clinical trial was performed to compare 0.1 and 0.3 mg/kg doses of IV midazolam in induction of sedation for head trauma infant patients in need of brain computed tomography (CT) scan. Conscious infants under 2 years old, with stable hemodynamics were included. Onset and duration of action as well as probable side effects were compared between the two groups using SPSS version 22. Results: 110 infants with the mean age of 14.0 §5.9 months (range: 4–24) and mean weight of 9.7±2 kg (range: 5–15) were randomly allocated to one of the 2 study groups (54.6% female). Success rate in 0.1 and 0.3 mg /kg groups were 38.2% (21 patients)and 60% (33 patients), respectively (p=0.018). Overall, 56 (50.9%) patients did not reach proper sedation and were sedated receiving ketamine (22 patients) or another dose of midazolam (34 patients, mean additional dose needed was 2.1±1.1 mg). Conclusion: The results of the present study demonstrated the higher success rate and longer duration of action for 0.3 mg /kg midazolam compared to 0.1 mg /kg. The groups were equal regarding onset of action, effect on vital signs and probable side effects. |
| first_indexed | 2024-04-11T22:59:01Z |
| format | Article |
| id | doaj.art-35ebfdec697c4bd2b945a058e0069119 |
| institution | Directory Open Access Journal |
| issn | 2645-4904 |
| language | English |
| last_indexed | 2024-04-11T22:59:01Z |
| publishDate | 2018-12-01 |
| publisher | Shahid Beheshti University of Medical Sciences |
| record_format | Article |
| series | Archives of Academic Emergency Medicine |
| spelling | doaj.art-35ebfdec697c4bd2b945a058e00691192022-12-22T03:58:15ZengShahid Beheshti University of Medical SciencesArchives of Academic Emergency Medicine2645-49042018-12-014410.22037/aaem.v4i4.249Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and AnalgesiaHassan Barzegari0Arash Forouzan1Kambiz Masoumi2Hassan Motamed3Behzad Zohrevandi4Shima Zeynadini Meymand5Department of Emergency Medicine, Imam Khomeini General Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Emergency Medicine, Imam Khomeini General Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Emergency Medicine, Imam Khomeini General Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Department of Emergency Medicine, Imam Khomeini General Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Road trauma Research Center, Guilan University of Medical Sciences, Rasht, Iran.Department of Emergency Medicine, Imam Khomeini General Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.Introduction: Midazolam has turned into a common drug for pediatric procedural sedation and analgesia. However, there is not much data regarding its proper dose and potential side effects in the Iranian children population. Therefore, the present study was done to compare 2 doses of IV midazolam in this regard. Methods: The present clinical trial was performed to compare 0.1 and 0.3 mg/kg doses of IV midazolam in induction of sedation for head trauma infant patients in need of brain computed tomography (CT) scan. Conscious infants under 2 years old, with stable hemodynamics were included. Onset and duration of action as well as probable side effects were compared between the two groups using SPSS version 22. Results: 110 infants with the mean age of 14.0 §5.9 months (range: 4–24) and mean weight of 9.7±2 kg (range: 5–15) were randomly allocated to one of the 2 study groups (54.6% female). Success rate in 0.1 and 0.3 mg /kg groups were 38.2% (21 patients)and 60% (33 patients), respectively (p=0.018). Overall, 56 (50.9%) patients did not reach proper sedation and were sedated receiving ketamine (22 patients) or another dose of midazolam (34 patients, mean additional dose needed was 2.1±1.1 mg). Conclusion: The results of the present study demonstrated the higher success rate and longer duration of action for 0.3 mg /kg midazolam compared to 0.1 mg /kg. The groups were equal regarding onset of action, effect on vital signs and probable side effects.https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/249conscious sedationdose-response relationshipdruginfantemergency servicehospital |
| spellingShingle | Hassan Barzegari Arash Forouzan Kambiz Masoumi Hassan Motamed Behzad Zohrevandi Shima Zeynadini Meymand Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and Analgesia Archives of Academic Emergency Medicine conscious sedation dose-response relationship drug infant emergency service hospital |
| title | Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and Analgesia |
| title_full | Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and Analgesia |
| title_fullStr | Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and Analgesia |
| title_full_unstemmed | Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and Analgesia |
| title_short | Comparing Two Different Doses of Intravenous Midazolamin in Pediatric Sedation and Analgesia |
| title_sort | comparing two different doses of intravenous midazolamin in pediatric sedation and analgesia |
| topic | conscious sedation dose-response relationship drug infant emergency service hospital |
| url | https://journals.sbmu.ac.ir/aaem/index.php/AAEM/article/view/249 |
| work_keys_str_mv | AT hassanbarzegari comparingtwodifferentdosesofintravenousmidazolamininpediatricsedationandanalgesia AT arashforouzan comparingtwodifferentdosesofintravenousmidazolamininpediatricsedationandanalgesia AT kambizmasoumi comparingtwodifferentdosesofintravenousmidazolamininpediatricsedationandanalgesia AT hassanmotamed comparingtwodifferentdosesofintravenousmidazolamininpediatricsedationandanalgesia AT behzadzohrevandi comparingtwodifferentdosesofintravenousmidazolamininpediatricsedationandanalgesia AT shimazeynadinimeymand comparingtwodifferentdosesofintravenousmidazolamininpediatricsedationandanalgesia |