A universal SARS‐CoV DNA vaccine inducing highly cross‐reactive neutralizing antibodies and T cells

A universal SARS‐CoV DNA vaccine inducing highly cross‐reactive neutralizing antibodies and T cells

Abstract New variants in the SARS‐CoV‐2 pandemic are more contagious (Alpha/Delta), evade neutralizing antibodies (Beta), or both (Omicron). This poses a challenge in vaccine development according to WHO. We designed a more universal SARS‐CoV‐2 DNA vaccine containing receptor‐binding domain loops fr...

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Bibliographic Details
Main Authors: Sofia Appelberg, Gustaf Ahlén, Jingyi Yan, Negin Nikouyan, Sofie Weber, Olivia Larsson, Urban Höglund, Soo Aleman, Friedemann Weber, Emma Perlhamre, Johanna Apro, Eva‐Karin Gidlund, Ola Tuvesson, Simona Salati, Matteo Cadossi, Hanna Tegel, Sophia Hober, Lars Frelin, Ali Mirazimi, Matti Sällberg
Format: Article
Language:English
Published: Springer Nature 2022-10-01
Series:EMBO Molecular Medicine
Subjects:
DNA vaccine
in vivo electroporation
preclinical development
SARS‐CoV‐2
universal SARS vaccine
Online Access:https://doi.org/10.15252/emmm.202215821

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