P3H4 Promotes Malignant Progression of Lung Adenocarcinoma via Interaction with EGFR
Lung cancer is associated with the greatest number of cancer-related deaths worldwide. Lung adenocarcinoma (LUAD) accounts for 85% of all cases of lung cancer. Despite recent advances in treatment, the 5-year survival rate remains less than 15%. Thus, the diagnostic and therapeutic role of LUAD rema...
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| Format: | Article |
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MDPI AG
2022-07-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/14/13/3243 |
| _version_ | 1797480597997748224 |
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| author | Chen Fang Yingkuan Liang Yong Huang Dong Jiang Jiaxi Li Haitao Ma Lingchuan Guo Wei Jiang Yu Feng |
| author_facet | Chen Fang Yingkuan Liang Yong Huang Dong Jiang Jiaxi Li Haitao Ma Lingchuan Guo Wei Jiang Yu Feng |
| author_sort | Chen Fang |
| collection | DOAJ |
| description | Lung cancer is associated with the greatest number of cancer-related deaths worldwide. Lung adenocarcinoma (LUAD) accounts for 85% of all cases of lung cancer. Despite recent advances in treatment, the 5-year survival rate remains less than 15%. Thus, the diagnostic and therapeutic role of LUAD remain to be further studied. The prolyl 3-hydroxylase family member 4 (P3H4) is involved in various cancers, but little is known about its role in LUAD. Our study demonstrated that the P3H4 gene was upregulated in LUAD. Clinically, the expression of P3H4 was positively correlated with an advanced TNM stage and shorter survival. Functionally, P3H4 plays a significant role in the metastasis and proliferation of LUAD both in vitro and in vivo. Mechanistically, P3H4 might interact with EGFR to regulate the metabolic substances. Our study indicated that P3H4 is a critical gene in the malignant progression of LUAD and represents a potential biomarker and therapeutic target. |
| first_indexed | 2024-03-09T22:02:22Z |
| format | Article |
| id | doaj.art-35ef9be1d3c9429eae66750b7846333a |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T22:02:22Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-35ef9be1d3c9429eae66750b7846333a2023-11-23T19:46:45ZengMDPI AGCancers2072-66942022-07-011413324310.3390/cancers14133243P3H4 Promotes Malignant Progression of Lung Adenocarcinoma via Interaction with EGFRChen Fang0Yingkuan Liang1Yong Huang2Dong Jiang3Jiaxi Li4Haitao Ma5Lingchuan Guo6Wei Jiang7Yu Feng8Department of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215000, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215000, ChinaDepartment of Thoracic Surgery, Haimen People’s Hospital, Nantong 226100, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215000, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215000, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215000, ChinaDepartment of Pathology, The First Affiliated Hospital of Soochow University, Suzhou 215000, ChinaDepartment of Thoracic Surgery, Dushu Lake Hospital Affiliated to Soochow University, Suzhou 215000, ChinaDepartment of Thoracic Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215000, ChinaLung cancer is associated with the greatest number of cancer-related deaths worldwide. Lung adenocarcinoma (LUAD) accounts for 85% of all cases of lung cancer. Despite recent advances in treatment, the 5-year survival rate remains less than 15%. Thus, the diagnostic and therapeutic role of LUAD remain to be further studied. The prolyl 3-hydroxylase family member 4 (P3H4) is involved in various cancers, but little is known about its role in LUAD. Our study demonstrated that the P3H4 gene was upregulated in LUAD. Clinically, the expression of P3H4 was positively correlated with an advanced TNM stage and shorter survival. Functionally, P3H4 plays a significant role in the metastasis and proliferation of LUAD both in vitro and in vivo. Mechanistically, P3H4 might interact with EGFR to regulate the metabolic substances. Our study indicated that P3H4 is a critical gene in the malignant progression of LUAD and represents a potential biomarker and therapeutic target.https://www.mdpi.com/2072-6694/14/13/3243lung adenocarcinomaP3H4EGFRmetabolism |
| spellingShingle | Chen Fang Yingkuan Liang Yong Huang Dong Jiang Jiaxi Li Haitao Ma Lingchuan Guo Wei Jiang Yu Feng P3H4 Promotes Malignant Progression of Lung Adenocarcinoma via Interaction with EGFR Cancers lung adenocarcinoma P3H4 EGFR metabolism |
| title | P3H4 Promotes Malignant Progression of Lung Adenocarcinoma via Interaction with EGFR |
| title_full | P3H4 Promotes Malignant Progression of Lung Adenocarcinoma via Interaction with EGFR |
| title_fullStr | P3H4 Promotes Malignant Progression of Lung Adenocarcinoma via Interaction with EGFR |
| title_full_unstemmed | P3H4 Promotes Malignant Progression of Lung Adenocarcinoma via Interaction with EGFR |
| title_short | P3H4 Promotes Malignant Progression of Lung Adenocarcinoma via Interaction with EGFR |
| title_sort | p3h4 promotes malignant progression of lung adenocarcinoma via interaction with egfr |
| topic | lung adenocarcinoma P3H4 EGFR metabolism |
| url | https://www.mdpi.com/2072-6694/14/13/3243 |
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