Reduced bone mineral density in patients with idiopathic inflammatory myopathies: a case-control study
Background: Patients with idiopathic inflammatory myopathies (IIMs) are at risk of reduced bone mineral density (BMD). Objectives: To compare the prevalence of reduced BMD between patients with IIMs and controls and to determine its risk factors. Design: This was a single-center case-control study....
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2023-07-01
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| Series: | Therapeutic Advances in Musculoskeletal Disease |
| Online Access: | https://doi.org/10.1177/1759720X231181968 |
| _version_ | 1797778021902450688 |
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| author | Iris Yan Ki Tang Lucas Luk Victor Wong Steve Pang Virginia Lao Ho So |
| author_facet | Iris Yan Ki Tang Lucas Luk Victor Wong Steve Pang Virginia Lao Ho So |
| author_sort | Iris Yan Ki Tang |
| collection | DOAJ |
| description | Background: Patients with idiopathic inflammatory myopathies (IIMs) are at risk of reduced bone mineral density (BMD). Objectives: To compare the prevalence of reduced BMD between patients with IIMs and controls and to determine its risk factors. Design: This was a single-center case-control study. Methods: BMD was assessed by dual-energy X-ray absorptiometry. The prevalence of reduced BMD in IIM patients and age-and sex-matched non-rheumatological controls was compared. The BMD results of female IIM were also compared to age-matched female rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients. Independent factors associated with reduced BMD in IIM patients were identified by multivariate analyses. Results: A total of 230 patients (IIM: 65, non-rheumatological controls: 65, RA: 50, SLE: 50) were recruited. The mean age of IIM patients was 58.6 ± 11.0 years and 76.9% were females. Significantly, more IIM patients had reduced BMD (73.8% versus 43.1%, p = 0.043) and osteoporosis (29.2% versus 13.8%, p = 0.033) than non-rheumatological controls. Multivariate analysis confirmed that IIM was independently associated with reduced BMD (OR: 2.12, p = 0.048, 95% CI: 1.01–4.46). The prevalence of reduced BMD was not significantly different between IIM, RA, and SLE patients but the mean hip BMD was the lowest in the IIM group (0.641 ± 0.152 g/cm 2 versus 0.663 ± 0.102g/cm 2 in the RA group versus 0.708 ± 0.132 g/cm 2 in the SLE group, p = 0.035). Lower body mass index and more advanced age were independently associated with lower BMD in IIM patients. Conclusion: Reduced BMD was more prevalent in IIM patients than in non-rheumatological controls. Hip BMD was lower in patients with IIMs than RA or SLE. Close monitoring and early treatment are encouraged especially in patients with risk factors. |
| first_indexed | 2024-03-12T23:12:17Z |
| format | Article |
| id | doaj.art-35efe9a353924bf99430e630cfe171a7 |
| institution | Directory Open Access Journal |
| issn | 1759-7218 |
| language | English |
| last_indexed | 2024-03-12T23:12:17Z |
| publishDate | 2023-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Therapeutic Advances in Musculoskeletal Disease |
| spelling | doaj.art-35efe9a353924bf99430e630cfe171a72023-07-17T21:33:36ZengSAGE PublishingTherapeutic Advances in Musculoskeletal Disease1759-72182023-07-011510.1177/1759720X231181968Reduced bone mineral density in patients with idiopathic inflammatory myopathies: a case-control studyIris Yan Ki TangLucas LukVictor WongSteve PangVirginia LaoHo SoBackground: Patients with idiopathic inflammatory myopathies (IIMs) are at risk of reduced bone mineral density (BMD). Objectives: To compare the prevalence of reduced BMD between patients with IIMs and controls and to determine its risk factors. Design: This was a single-center case-control study. Methods: BMD was assessed by dual-energy X-ray absorptiometry. The prevalence of reduced BMD in IIM patients and age-and sex-matched non-rheumatological controls was compared. The BMD results of female IIM were also compared to age-matched female rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) patients. Independent factors associated with reduced BMD in IIM patients were identified by multivariate analyses. Results: A total of 230 patients (IIM: 65, non-rheumatological controls: 65, RA: 50, SLE: 50) were recruited. The mean age of IIM patients was 58.6 ± 11.0 years and 76.9% were females. Significantly, more IIM patients had reduced BMD (73.8% versus 43.1%, p = 0.043) and osteoporosis (29.2% versus 13.8%, p = 0.033) than non-rheumatological controls. Multivariate analysis confirmed that IIM was independently associated with reduced BMD (OR: 2.12, p = 0.048, 95% CI: 1.01–4.46). The prevalence of reduced BMD was not significantly different between IIM, RA, and SLE patients but the mean hip BMD was the lowest in the IIM group (0.641 ± 0.152 g/cm 2 versus 0.663 ± 0.102g/cm 2 in the RA group versus 0.708 ± 0.132 g/cm 2 in the SLE group, p = 0.035). Lower body mass index and more advanced age were independently associated with lower BMD in IIM patients. Conclusion: Reduced BMD was more prevalent in IIM patients than in non-rheumatological controls. Hip BMD was lower in patients with IIMs than RA or SLE. Close monitoring and early treatment are encouraged especially in patients with risk factors.https://doi.org/10.1177/1759720X231181968 |
| spellingShingle | Iris Yan Ki Tang Lucas Luk Victor Wong Steve Pang Virginia Lao Ho So Reduced bone mineral density in patients with idiopathic inflammatory myopathies: a case-control study Therapeutic Advances in Musculoskeletal Disease |
| title | Reduced bone mineral density in patients with idiopathic inflammatory myopathies: a case-control study |
| title_full | Reduced bone mineral density in patients with idiopathic inflammatory myopathies: a case-control study |
| title_fullStr | Reduced bone mineral density in patients with idiopathic inflammatory myopathies: a case-control study |
| title_full_unstemmed | Reduced bone mineral density in patients with idiopathic inflammatory myopathies: a case-control study |
| title_short | Reduced bone mineral density in patients with idiopathic inflammatory myopathies: a case-control study |
| title_sort | reduced bone mineral density in patients with idiopathic inflammatory myopathies a case control study |
| url | https://doi.org/10.1177/1759720X231181968 |
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