Impurity profiling method development and validation of metformin hydrochloride and teneligliptin hydrobromide hydrate in their combination tablet dosage form by using RP-HPLC with UV/PDA detector

Impurity profiling method development and validation of metformin hydrochloride and teneligliptin hydrobromide hydrate in their combination tablet dosage form by using RP-HPLC with UV/PDA detector

Abstract Background An accurate, precise and robust analytical method was developed for the impurity profiling in the metformin hydrochloride and teneligliptin hydrobromide hydrate tablet. The gradient was optimized for better separation of impurities by using BDS Hypersil C18 250 × 4.6 mm, 5µ colum...

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Bibliographic Details
Main Authors: B. D. Musmade, M. L. Baraskar, V. N. Ghodke, S. G. Bhope, S. Padmanabhan, K. S. Lohar
Format: Article
Language:English
Published: SpringerOpen 2021-10-01
Series:Future Journal of Pharmaceutical Sciences
Subjects:
Metformin hydrochloride
Teneligliptin hydrobromide hydrate
Method validation
Impurity profiling
Online Access:https://doi.org/10.1186/s43094-021-00362-9

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