Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents
Summary: The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing and in vitro electrophysiology data, however, show a markedly diffe...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Cell Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211124723000128 |
| _version_ | 1797946217465905152 |
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| author | Shinya Ohara Märt Rannap Ken-Ichiro Tsutsui Andreas Draguhn Alexei V. Egorov Menno P. Witter |
| author_facet | Shinya Ohara Märt Rannap Ken-Ichiro Tsutsui Andreas Draguhn Alexei V. Egorov Menno P. Witter |
| author_sort | Shinya Ohara |
| collection | DOAJ |
| description | Summary: The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing and in vitro electrophysiology data, however, show a markedly different dorsoventral organization of the hippocampal projection to the medial EC (MEC). While dorsal hippocampal projections are confined to the dorsal MEC, ventral hippocampal projections innervate both dorsal and ventral MEC. Further, whereas the dorsal hippocampus preferentially targets layer Vb (LVb) neurons, the ventral hippocampus mainly targets cells in layer Va (LVa). This connectivity scheme differs from hippocampal projections to the lateral EC, which are topographically organized along the dorsoventral axis. As LVa neurons project to telencephalic structures, our findings indicate that the ventral hippocampus regulates LVa-mediated entorhinal-neocortical output from both dorsal and ventral MEC. Overall, the marked dorsoventral differences in hippocampal-entorhinal connectivity impose important constraints on signal flow in hippocampal-neocortical circuits. |
| first_indexed | 2024-04-10T21:07:29Z |
| format | Article |
| id | doaj.art-35f300b845b34bc887359496e45ada3b |
| institution | Directory Open Access Journal |
| issn | 2211-1247 |
| language | English |
| last_indexed | 2024-04-10T21:07:29Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Cell Reports |
| spelling | doaj.art-35f300b845b34bc887359496e45ada3b2023-01-22T04:39:02ZengElsevierCell Reports2211-12472023-01-01421112001Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodentsShinya Ohara0Märt Rannap1Ken-Ichiro Tsutsui2Andreas Draguhn3Alexei V. Egorov4Menno P. Witter5Laboratory of Systems Neuroscience, Tohoku University Graduate School of Life Sciences, Sendai, Japan; Kavli Institute for Systems Neuroscience, Center for Computational Neuroscience, Egil and Pauline Braathen and Fred Kavli Center for Cortical Microcircuits, NTNU Norwegian University of Science and Technology, Trondheim, Norway; PRESTO, Japan Science and Technology Agency (JST), Tokyo, JapanInstitute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Heidelberg, GermanyLaboratory of Systems Neuroscience, Tohoku University Graduate School of Life Sciences, Sendai, JapanInstitute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Heidelberg, GermanyInstitute of Physiology and Pathophysiology, Medical Faculty, Heidelberg University, Heidelberg, Germany; Corresponding authorKavli Institute for Systems Neuroscience, Center for Computational Neuroscience, Egil and Pauline Braathen and Fred Kavli Center for Cortical Microcircuits, NTNU Norwegian University of Science and Technology, Trondheim, Norway; Corresponding authorSummary: The general understanding of hippocampal circuits is that the hippocampus and the entorhinal cortex (EC) are topographically connected through parallel identical circuits along the dorsoventral axis. Our anterograde tracing and in vitro electrophysiology data, however, show a markedly different dorsoventral organization of the hippocampal projection to the medial EC (MEC). While dorsal hippocampal projections are confined to the dorsal MEC, ventral hippocampal projections innervate both dorsal and ventral MEC. Further, whereas the dorsal hippocampus preferentially targets layer Vb (LVb) neurons, the ventral hippocampus mainly targets cells in layer Va (LVa). This connectivity scheme differs from hippocampal projections to the lateral EC, which are topographically organized along the dorsoventral axis. As LVa neurons project to telencephalic structures, our findings indicate that the ventral hippocampus regulates LVa-mediated entorhinal-neocortical output from both dorsal and ventral MEC. Overall, the marked dorsoventral differences in hippocampal-entorhinal connectivity impose important constraints on signal flow in hippocampal-neocortical circuits.http://www.sciencedirect.com/science/article/pii/S2211124723000128CP: Neuroscience |
| spellingShingle | Shinya Ohara Märt Rannap Ken-Ichiro Tsutsui Andreas Draguhn Alexei V. Egorov Menno P. Witter Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents Cell Reports CP: Neuroscience |
| title | Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents |
| title_full | Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents |
| title_fullStr | Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents |
| title_full_unstemmed | Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents |
| title_short | Hippocampal-medial entorhinal circuit is differently organized along the dorsoventral axis in rodents |
| title_sort | hippocampal medial entorhinal circuit is differently organized along the dorsoventral axis in rodents |
| topic | CP: Neuroscience |
| url | http://www.sciencedirect.com/science/article/pii/S2211124723000128 |
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