Repeatability and comparison of 2D and 4D flow MRI measurement of intracranial blood flow and pulsatility in healthy individuals and patients with cerebral small vessel disease
IntroductionWhile 2D phase-contrast MRI is often used to examine intracranial vessels in neurovascular disease contexts, the ability of 4D flow to assess many vessels at once makes it an attractive alternative. We aimed to assess the repeatability, reliability, and conformity of 2D and 4D flow acros...
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| Format: | Article |
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Psychology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1125038/full |
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| author | Alasdair G. Morgan Alasdair G. Morgan Alasdair G. Morgan Michael J. Thrippleton Michael J. Thrippleton Michael J. Thrippleton Michael Stringer Michael Stringer Michael Stringer Ning Jin Joanna M. Wardlaw Joanna M. Wardlaw Joanna M. Wardlaw Ian Marshall Ian Marshall Ian Marshall |
| author_facet | Alasdair G. Morgan Alasdair G. Morgan Alasdair G. Morgan Michael J. Thrippleton Michael J. Thrippleton Michael J. Thrippleton Michael Stringer Michael Stringer Michael Stringer Ning Jin Joanna M. Wardlaw Joanna M. Wardlaw Joanna M. Wardlaw Ian Marshall Ian Marshall Ian Marshall |
| author_sort | Alasdair G. Morgan |
| collection | DOAJ |
| description | IntroductionWhile 2D phase-contrast MRI is often used to examine intracranial vessels in neurovascular disease contexts, the ability of 4D flow to assess many vessels at once makes it an attractive alternative. We aimed to assess the repeatability, reliability, and conformity of 2D and 4D flow across intracranial vessels.MethodsUsing correlation analyses and paired t-tests, test-retest repeatability, intra-rater reliability, and inter-method conformity for measurements of pulsatility index (PI) and mean flow were assessed in the arteries and veins of 11 healthy volunteers. Inter-method conformity was also assessed in 10 patients with small vessel disease.ResultsRepeatability for PI measurements was mostly classed as good using both 2D (median ICC = 0.765) and 4D (0.772) methods, and for mean flow was mostly moderate across both (2D: 0.711, 4D: 0.571). 4D reliability was good for PI (0.877–0.906) and moderate for mean flow (0.459–0.723). Arterial PI measurements were generally higher using the 2D method, while mean flow was mostly higher using 4D flow.DiscussionThese results imply that PI measurement using 4D flow is repeatable and reliable across intracranial arteries and veins, but care should be paid to absolute flow measurements as they are susceptible to variation depending on slice placement, resolution, and lumen segmentation practices. |
| first_indexed | 2024-03-13T08:41:50Z |
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| id | doaj.art-35f6027d18c94019ae5abf1f82c0d05c |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-03-13T08:41:50Z |
| publishDate | 2023-05-01 |
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| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-35f6027d18c94019ae5abf1f82c0d05c2023-05-30T09:13:38ZengFrontiers Media S.A.Frontiers in Psychology1664-10782023-05-011410.3389/fpsyg.2023.11250381125038Repeatability and comparison of 2D and 4D flow MRI measurement of intracranial blood flow and pulsatility in healthy individuals and patients with cerebral small vessel diseaseAlasdair G. Morgan0Alasdair G. Morgan1Alasdair G. Morgan2Michael J. Thrippleton3Michael J. Thrippleton4Michael J. Thrippleton5Michael Stringer6Michael Stringer7Michael Stringer8Ning Jin9Joanna M. Wardlaw10Joanna M. Wardlaw11Joanna M. Wardlaw12Ian Marshall13Ian Marshall14Ian Marshall15Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United KingdomUK Dementia Research Institute, University of Edinburgh, Edinburgh, United KingdomEdinburgh Imaging, University of Edinburgh, Edinburgh, United KingdomCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United KingdomUK Dementia Research Institute, University of Edinburgh, Edinburgh, United KingdomEdinburgh Imaging, University of Edinburgh, Edinburgh, United KingdomCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United KingdomUK Dementia Research Institute, University of Edinburgh, Edinburgh, United KingdomEdinburgh Imaging, University of Edinburgh, Edinburgh, United KingdomSiemens Medical Solutions USA, Inc., Cleveland, OH, United StatesCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United KingdomUK Dementia Research Institute, University of Edinburgh, Edinburgh, United KingdomEdinburgh Imaging, University of Edinburgh, Edinburgh, United KingdomCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United KingdomUK Dementia Research Institute, University of Edinburgh, Edinburgh, United KingdomEdinburgh Imaging, University of Edinburgh, Edinburgh, United KingdomIntroductionWhile 2D phase-contrast MRI is often used to examine intracranial vessels in neurovascular disease contexts, the ability of 4D flow to assess many vessels at once makes it an attractive alternative. We aimed to assess the repeatability, reliability, and conformity of 2D and 4D flow across intracranial vessels.MethodsUsing correlation analyses and paired t-tests, test-retest repeatability, intra-rater reliability, and inter-method conformity for measurements of pulsatility index (PI) and mean flow were assessed in the arteries and veins of 11 healthy volunteers. Inter-method conformity was also assessed in 10 patients with small vessel disease.ResultsRepeatability for PI measurements was mostly classed as good using both 2D (median ICC = 0.765) and 4D (0.772) methods, and for mean flow was mostly moderate across both (2D: 0.711, 4D: 0.571). 4D reliability was good for PI (0.877–0.906) and moderate for mean flow (0.459–0.723). Arterial PI measurements were generally higher using the 2D method, while mean flow was mostly higher using 4D flow.DiscussionThese results imply that PI measurement using 4D flow is repeatable and reliable across intracranial arteries and veins, but care should be paid to absolute flow measurements as they are susceptible to variation depending on slice placement, resolution, and lumen segmentation practices.https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1125038/fullflow imagingpulsatilityintracranial vessels4D flowphase-contrastMRI |
| spellingShingle | Alasdair G. Morgan Alasdair G. Morgan Alasdair G. Morgan Michael J. Thrippleton Michael J. Thrippleton Michael J. Thrippleton Michael Stringer Michael Stringer Michael Stringer Ning Jin Joanna M. Wardlaw Joanna M. Wardlaw Joanna M. Wardlaw Ian Marshall Ian Marshall Ian Marshall Repeatability and comparison of 2D and 4D flow MRI measurement of intracranial blood flow and pulsatility in healthy individuals and patients with cerebral small vessel disease Frontiers in Psychology flow imaging pulsatility intracranial vessels 4D flow phase-contrast MRI |
| title | Repeatability and comparison of 2D and 4D flow MRI measurement of intracranial blood flow and pulsatility in healthy individuals and patients with cerebral small vessel disease |
| title_full | Repeatability and comparison of 2D and 4D flow MRI measurement of intracranial blood flow and pulsatility in healthy individuals and patients with cerebral small vessel disease |
| title_fullStr | Repeatability and comparison of 2D and 4D flow MRI measurement of intracranial blood flow and pulsatility in healthy individuals and patients with cerebral small vessel disease |
| title_full_unstemmed | Repeatability and comparison of 2D and 4D flow MRI measurement of intracranial blood flow and pulsatility in healthy individuals and patients with cerebral small vessel disease |
| title_short | Repeatability and comparison of 2D and 4D flow MRI measurement of intracranial blood flow and pulsatility in healthy individuals and patients with cerebral small vessel disease |
| title_sort | repeatability and comparison of 2d and 4d flow mri measurement of intracranial blood flow and pulsatility in healthy individuals and patients with cerebral small vessel disease |
| topic | flow imaging pulsatility intracranial vessels 4D flow phase-contrast MRI |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2023.1125038/full |
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