Contribution of microvascular dysfunction to chronic pain
There is growing evidence that microvascular dysfunction is a pathology accompanying various injuries and conditions that produce chronic pain and may represent a significant contributing factor. Dysfunction that occurs within each component of the microvasculature, including arterioles, capillaries...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Pain Research |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpain.2023.1111559/full |
| _version_ | 1828046122982047744 |
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| author | Terence J. Coderre |
| author_facet | Terence J. Coderre |
| author_sort | Terence J. Coderre |
| collection | DOAJ |
| description | There is growing evidence that microvascular dysfunction is a pathology accompanying various injuries and conditions that produce chronic pain and may represent a significant contributing factor. Dysfunction that occurs within each component of the microvasculature, including arterioles, capillaries and venules impacts the health of surrounding tissue and produces pathology that can both initiate pain and influence pain sensitivity. This mini review will discuss evidence for a critical role of microvascular dysfunction or injury in pathologies that contribute to chronic pain conditions such as complex regional pain syndrome (CRPS) and fibromyalgia. |
| first_indexed | 2024-04-10T18:21:01Z |
| format | Article |
| id | doaj.art-35f6fc804cc445d7bdde1a714c8ebae3 |
| institution | Directory Open Access Journal |
| issn | 2673-561X |
| language | English |
| last_indexed | 2024-04-10T18:21:01Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pain Research |
| spelling | doaj.art-35f6fc804cc445d7bdde1a714c8ebae32023-02-02T07:09:30ZengFrontiers Media S.A.Frontiers in Pain Research2673-561X2023-02-01410.3389/fpain.2023.11115591111559Contribution of microvascular dysfunction to chronic painTerence J. CoderreThere is growing evidence that microvascular dysfunction is a pathology accompanying various injuries and conditions that produce chronic pain and may represent a significant contributing factor. Dysfunction that occurs within each component of the microvasculature, including arterioles, capillaries and venules impacts the health of surrounding tissue and produces pathology that can both initiate pain and influence pain sensitivity. This mini review will discuss evidence for a critical role of microvascular dysfunction or injury in pathologies that contribute to chronic pain conditions such as complex regional pain syndrome (CRPS) and fibromyalgia.https://www.frontiersin.org/articles/10.3389/fpain.2023.1111559/fullendothelial cellsmicrovascular injuryischemia-reperfusionoxidative stressantioxidantscytokines |
| spellingShingle | Terence J. Coderre Contribution of microvascular dysfunction to chronic pain Frontiers in Pain Research endothelial cells microvascular injury ischemia-reperfusion oxidative stress antioxidants cytokines |
| title | Contribution of microvascular dysfunction to chronic pain |
| title_full | Contribution of microvascular dysfunction to chronic pain |
| title_fullStr | Contribution of microvascular dysfunction to chronic pain |
| title_full_unstemmed | Contribution of microvascular dysfunction to chronic pain |
| title_short | Contribution of microvascular dysfunction to chronic pain |
| title_sort | contribution of microvascular dysfunction to chronic pain |
| topic | endothelial cells microvascular injury ischemia-reperfusion oxidative stress antioxidants cytokines |
| url | https://www.frontiersin.org/articles/10.3389/fpain.2023.1111559/full |
| work_keys_str_mv | AT terencejcoderre contributionofmicrovasculardysfunctiontochronicpain |