Anesthetic management for oocyte retrieval: An exploratory analysis comparing outcome in in vitro fertilization cycles with and without pre-implantation genetic diagnosis
Purpose: To date, there has been no comparison of outcomes in women undergoing anesthesia for in vitro fertilization (IVF) oocyte retrieval for the purpose of pre-implantation genetic diagnosis (PGD) because of their or their partner′s genetic disease relative to the outcome in women requiring IVF b...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2013-01-01
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| Series: | Journal of Human Reproductive Sciences |
| Subjects: | |
| Online Access: | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2013;volume=6;issue=4;spage=263;epage=266;aulast=Ioscovich |
| _version_ | 1818247786855923712 |
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| author | Alexander Ioscovich Talia Eldar-Geva Marina Weitman Gheona Altarescu Alina Rivilis Deborah Elstein |
| author_facet | Alexander Ioscovich Talia Eldar-Geva Marina Weitman Gheona Altarescu Alina Rivilis Deborah Elstein |
| author_sort | Alexander Ioscovich |
| collection | DOAJ |
| description | Purpose: To date, there has been no comparison of outcomes in women undergoing anesthesia for in vitro fertilization (IVF) oocyte retrieval for the purpose of pre-implantation genetic diagnosis (PGD) because of their or their partner′s genetic disease relative to the outcome in women requiring IVF because of fertility issues. Materials and Methods: A prospective observational study, wherein all demographic and anesthetic management data were collected from IVF and PGD units′ records for a 6-month period. Descriptive analyses and parametric tests were employed. Results: There were 307 cases IVF and 76 cases PGD: most (97.4% and 99.7%, respectively) received general anesthesia with propofol and fentanyl ± dipyrone (90.5% and 93.3%, respectively) with no adverse effects. The only statistically significant difference between IVF and PGD groups that was potentially clinically significant was post-procedure recovery time (23.0 ± 20.4 vs. 29.4 ± 35.8 min, respectively; P < 0.0001), but is explainable as greater caution by Anesthesiologists for higher-risk PGD cases having autosomal dominant diseases that may impact anesthesia management (myotonic dystrophy, neurofibromatosis, Marfan′s); two of these cases also recovered in the general post-anesthesia care unit, as a precaution for early diagnosis and treatment of potential post-procedural complication. Conclusions: Results of this first-ever survey of anesthesia for PGD compared with IVF cases imply that propofol-and-fentanyl-based anesthesia is safe and can be recommended, bearing in mind that with patients who have autosomal dominant diseases impacting anesthetic management it is prudent to be more cautious post-recovery. |
| first_indexed | 2024-12-12T15:10:15Z |
| format | Article |
| id | doaj.art-35f77a179434402eb7d239b3b56ba784 |
| institution | Directory Open Access Journal |
| issn | 0974-1208 1998-4766 |
| language | English |
| last_indexed | 2024-12-12T15:10:15Z |
| publishDate | 2013-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Human Reproductive Sciences |
| spelling | doaj.art-35f77a179434402eb7d239b3b56ba7842022-12-22T00:20:39ZengWolters Kluwer Medknow PublicationsJournal of Human Reproductive Sciences0974-12081998-47662013-01-016426326610.4103/0974-1208.126303Anesthetic management for oocyte retrieval: An exploratory analysis comparing outcome in in vitro fertilization cycles with and without pre-implantation genetic diagnosisAlexander IoscovichTalia Eldar-GevaMarina WeitmanGheona AltarescuAlina RivilisDeborah ElsteinPurpose: To date, there has been no comparison of outcomes in women undergoing anesthesia for in vitro fertilization (IVF) oocyte retrieval for the purpose of pre-implantation genetic diagnosis (PGD) because of their or their partner′s genetic disease relative to the outcome in women requiring IVF because of fertility issues. Materials and Methods: A prospective observational study, wherein all demographic and anesthetic management data were collected from IVF and PGD units′ records for a 6-month period. Descriptive analyses and parametric tests were employed. Results: There were 307 cases IVF and 76 cases PGD: most (97.4% and 99.7%, respectively) received general anesthesia with propofol and fentanyl ± dipyrone (90.5% and 93.3%, respectively) with no adverse effects. The only statistically significant difference between IVF and PGD groups that was potentially clinically significant was post-procedure recovery time (23.0 ± 20.4 vs. 29.4 ± 35.8 min, respectively; P < 0.0001), but is explainable as greater caution by Anesthesiologists for higher-risk PGD cases having autosomal dominant diseases that may impact anesthesia management (myotonic dystrophy, neurofibromatosis, Marfan′s); two of these cases also recovered in the general post-anesthesia care unit, as a precaution for early diagnosis and treatment of potential post-procedural complication. Conclusions: Results of this first-ever survey of anesthesia for PGD compared with IVF cases imply that propofol-and-fentanyl-based anesthesia is safe and can be recommended, bearing in mind that with patients who have autosomal dominant diseases impacting anesthetic management it is prudent to be more cautious post-recovery.http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2013;volume=6;issue=4;spage=263;epage=266;aulast=IoscovichAutosomal dominant diseasesgeneral anesthesiain vitro fertilizationmaternal outcomeneonatal outcomepre-implantation genetic diagnosisrecovery time |
| spellingShingle | Alexander Ioscovich Talia Eldar-Geva Marina Weitman Gheona Altarescu Alina Rivilis Deborah Elstein Anesthetic management for oocyte retrieval: An exploratory analysis comparing outcome in in vitro fertilization cycles with and without pre-implantation genetic diagnosis Journal of Human Reproductive Sciences Autosomal dominant diseases general anesthesia in vitro fertilization maternal outcome neonatal outcome pre-implantation genetic diagnosis recovery time |
| title | Anesthetic management for oocyte retrieval: An exploratory analysis comparing outcome in in vitro fertilization cycles with and without pre-implantation genetic diagnosis |
| title_full | Anesthetic management for oocyte retrieval: An exploratory analysis comparing outcome in in vitro fertilization cycles with and without pre-implantation genetic diagnosis |
| title_fullStr | Anesthetic management for oocyte retrieval: An exploratory analysis comparing outcome in in vitro fertilization cycles with and without pre-implantation genetic diagnosis |
| title_full_unstemmed | Anesthetic management for oocyte retrieval: An exploratory analysis comparing outcome in in vitro fertilization cycles with and without pre-implantation genetic diagnosis |
| title_short | Anesthetic management for oocyte retrieval: An exploratory analysis comparing outcome in in vitro fertilization cycles with and without pre-implantation genetic diagnosis |
| title_sort | anesthetic management for oocyte retrieval an exploratory analysis comparing outcome in in vitro fertilization cycles with and without pre implantation genetic diagnosis |
| topic | Autosomal dominant diseases general anesthesia in vitro fertilization maternal outcome neonatal outcome pre-implantation genetic diagnosis recovery time |
| url | http://www.jhrsonline.org/article.asp?issn=0974-1208;year=2013;volume=6;issue=4;spage=263;epage=266;aulast=Ioscovich |
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