Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity

Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity

Engineered allosteric regulation of protein activity provides significant advantages for the development of robust and broadly applicable tools. However, the application of allosteric switches in optogenetics has been scarce and suffers from critical limitations. Here, we report an optogenetic appro...

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Bibliographic Details
Main Authors: Mark Shaaya, Jordan Fauser, Anastasia Zhurikhina, Jason E Conage-Pough, Vincent Huyot, Martin Brennan, Cameron T Flower, Jacob Matsche, Shahzeb Khan, Viswanathan Natarajan, Jalees Rehman, Pradeep Kota, Forest M White, Denis Tsygankov, Andrei V Karginov
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
optogenetics
allosteric
enzyme
protein kinase
Src
protein engineering
Online Access:https://elifesciences.org/articles/60647

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