Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age
Maintaining synaptic structure and function over time is vital for overall nervous system function and survival. The processes that underly synaptic development are well understood. However, the mechanisms responsible for sustaining synapses throughout the lifespan of an organism are poorly understo...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
eLife Sciences Publications Ltd
2021-03-01
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| Series: | eLife |
| Subjects: | |
| Online Access: | https://elifesciences.org/articles/54932 |
| _version_ | 1811228104433074176 |
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| author | Jessica M Sidisky Daniel Weaver Sarrah Hussain Meryem Okumus Russell Caratenuto Daniel Babcock |
| author_facet | Jessica M Sidisky Daniel Weaver Sarrah Hussain Meryem Okumus Russell Caratenuto Daniel Babcock |
| author_sort | Jessica M Sidisky |
| collection | DOAJ |
| description | Maintaining synaptic structure and function over time is vital for overall nervous system function and survival. The processes that underly synaptic development are well understood. However, the mechanisms responsible for sustaining synapses throughout the lifespan of an organism are poorly understood. Here, we demonstrate that a previously uncharacterized gene, CG31475, regulates synaptic maintenance in adult Drosophila NMJs. We named CG31475 mayday due to the progressive loss of flight ability and synapse architecture with age. Mayday is functionally homologous to the human protein Cab45, which sorts secretory cargo from the Trans Golgi Network (TGN). We find that Mayday is required to maintain trans-synaptic BMP signaling at adult NMJs in order to sustain proper synaptic structure and function. Finally, we show that mutations in mayday result in the loss of both presynaptic motor neurons as well as postsynaptic muscles, highlighting the importance of maintaining synaptic integrity for cell viability. |
| first_indexed | 2024-04-12T09:52:52Z |
| format | Article |
| id | doaj.art-35f9c28d1a484ac5bd914e934ecd407d |
| institution | Directory Open Access Journal |
| issn | 2050-084X |
| language | English |
| last_indexed | 2024-04-12T09:52:52Z |
| publishDate | 2021-03-01 |
| publisher | eLife Sciences Publications Ltd |
| record_format | Article |
| series | eLife |
| spelling | doaj.art-35f9c28d1a484ac5bd914e934ecd407d2022-12-22T03:37:47ZengeLife Sciences Publications LtdeLife2050-084X2021-03-011010.7554/eLife.54932Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with ageJessica M Sidisky0Daniel Weaver1Sarrah Hussain2Meryem Okumus3Russell Caratenuto4Daniel Babcock5https://orcid.org/0000-0002-8102-9133Department of Biological Sciences, Lehigh University, Bethlehem, United StatesDepartment of Biological Sciences, Lehigh University, Bethlehem, United StatesDepartment of Biological Sciences, Lehigh University, Bethlehem, United StatesDepartment of Biological Sciences, Lehigh University, Bethlehem, United StatesDepartment of Biological Sciences, Lehigh University, Bethlehem, United StatesDepartment of Biological Sciences, Lehigh University, Bethlehem, United StatesMaintaining synaptic structure and function over time is vital for overall nervous system function and survival. The processes that underly synaptic development are well understood. However, the mechanisms responsible for sustaining synapses throughout the lifespan of an organism are poorly understood. Here, we demonstrate that a previously uncharacterized gene, CG31475, regulates synaptic maintenance in adult Drosophila NMJs. We named CG31475 mayday due to the progressive loss of flight ability and synapse architecture with age. Mayday is functionally homologous to the human protein Cab45, which sorts secretory cargo from the Trans Golgi Network (TGN). We find that Mayday is required to maintain trans-synaptic BMP signaling at adult NMJs in order to sustain proper synaptic structure and function. Finally, we show that mutations in mayday result in the loss of both presynaptic motor neurons as well as postsynaptic muscles, highlighting the importance of maintaining synaptic integrity for cell viability.https://elifesciences.org/articles/54932Drosophilaflightsynapseneuromuscular junction |
| spellingShingle | Jessica M Sidisky Daniel Weaver Sarrah Hussain Meryem Okumus Russell Caratenuto Daniel Babcock Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age eLife Drosophila flight synapse neuromuscular junction |
| title | Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age |
| title_full | Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age |
| title_fullStr | Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age |
| title_full_unstemmed | Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age |
| title_short | Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age |
| title_sort | mayday sustains trans synaptic bmp signaling required for synaptic maintenance with age |
| topic | Drosophila flight synapse neuromuscular junction |
| url | https://elifesciences.org/articles/54932 |
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