Engineering protein assemblies with allosteric control via monomer fold-switching
The design of protein assemblies is a major thrust for biomolecular engineering and nanobiotechnology. Here the authors demonstrate a general mechanism for designing allosteric macromolecular assemblies and showcase a proof of concept for engineered allosteric protein assembly.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2019-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-13686-1 |
| _version_ | 1819129249239400448 |
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| author | Luis A. Campos Rajendra Sharma Sara Alvira Federico M. Ruiz Beatriz Ibarra-Molero Mourad Sadqi Carlos Alfonso Germán Rivas Jose M. Sanchez-Ruiz Antonio Romero Garrido José M. Valpuesta Victor Muñoz |
| author_facet | Luis A. Campos Rajendra Sharma Sara Alvira Federico M. Ruiz Beatriz Ibarra-Molero Mourad Sadqi Carlos Alfonso Germán Rivas Jose M. Sanchez-Ruiz Antonio Romero Garrido José M. Valpuesta Victor Muñoz |
| author_sort | Luis A. Campos |
| collection | DOAJ |
| description | The design of protein assemblies is a major thrust for biomolecular engineering and nanobiotechnology. Here the authors demonstrate a general mechanism for designing allosteric macromolecular assemblies and showcase a proof of concept for engineered allosteric protein assembly. |
| first_indexed | 2024-12-22T08:40:43Z |
| format | Article |
| id | doaj.art-35fa5f2626334f038b8530ed1e35e4fe |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-22T08:40:43Z |
| publishDate | 2019-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-35fa5f2626334f038b8530ed1e35e4fe2022-12-21T18:32:14ZengNature PortfolioNature Communications2041-17232019-12-0110111310.1038/s41467-019-13686-1Engineering protein assemblies with allosteric control via monomer fold-switchingLuis A. Campos0Rajendra Sharma1Sara Alvira2Federico M. Ruiz3Beatriz Ibarra-Molero4Mourad Sadqi5Carlos Alfonso6Germán Rivas7Jose M. Sanchez-Ruiz8Antonio Romero Garrido9José M. Valpuesta10Victor Muñoz11Centro Nacional de Biotecnología (CNB-CSIC)Centro Nacional de Biotecnología (CNB-CSIC)Centro Nacional de Biotecnología (CNB-CSIC)Centro de Investigaciones Biológicas (CIB-CSIC)Departamento de Química Física, Facultad de Ciencias, Universidad de GranadaDepartment of Bioengineering, University of CaliforniaCentro de Investigaciones Biológicas (CIB-CSIC)Centro de Investigaciones Biológicas (CIB-CSIC)Departamento de Química Física, Facultad de Ciencias, Universidad de GranadaCentro de Investigaciones Biológicas (CIB-CSIC)Centro Nacional de Biotecnología (CNB-CSIC)Centro Nacional de Biotecnología (CNB-CSIC)The design of protein assemblies is a major thrust for biomolecular engineering and nanobiotechnology. Here the authors demonstrate a general mechanism for designing allosteric macromolecular assemblies and showcase a proof of concept for engineered allosteric protein assembly.https://doi.org/10.1038/s41467-019-13686-1 |
| spellingShingle | Luis A. Campos Rajendra Sharma Sara Alvira Federico M. Ruiz Beatriz Ibarra-Molero Mourad Sadqi Carlos Alfonso Germán Rivas Jose M. Sanchez-Ruiz Antonio Romero Garrido José M. Valpuesta Victor Muñoz Engineering protein assemblies with allosteric control via monomer fold-switching Nature Communications |
| title | Engineering protein assemblies with allosteric control via monomer fold-switching |
| title_full | Engineering protein assemblies with allosteric control via monomer fold-switching |
| title_fullStr | Engineering protein assemblies with allosteric control via monomer fold-switching |
| title_full_unstemmed | Engineering protein assemblies with allosteric control via monomer fold-switching |
| title_short | Engineering protein assemblies with allosteric control via monomer fold-switching |
| title_sort | engineering protein assemblies with allosteric control via monomer fold switching |
| url | https://doi.org/10.1038/s41467-019-13686-1 |
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