Fertility restoration of racing mare with persistent corpus luteum
Background and Aim: Persistent corpus luteum (PCL) causes anestrus in mares. This study aimed to determine the effect of intrauterine prostaglandin F2α (PGF2α) treatment on PCL of racing mares to restore fertility. Materials and Methods: Twelve racing mares suspected with PCL were diagnosed using...
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| Format: | Article |
| Language: | English |
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Veterinary World
2021-09-01
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| Series: | Veterinary World |
| Subjects: | |
| Online Access: | http://www.veterinaryworld.org/Vol.14/September-2021/9.pdf |
| _version_ | 1819143656178712576 |
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| author | Tjok Gde Oka Pemayun Imam Mustofa Laba Mahaputra Herry Agoes Hermadi Ngakan Made Rai Wijaya Sri Mulyati Suzanita Utama Tjuk Imam Restiadi Rimayanti Rimayanti |
| author_facet | Tjok Gde Oka Pemayun Imam Mustofa Laba Mahaputra Herry Agoes Hermadi Ngakan Made Rai Wijaya Sri Mulyati Suzanita Utama Tjuk Imam Restiadi Rimayanti Rimayanti |
| author_sort | Tjok Gde Oka Pemayun |
| collection | DOAJ |
| description | Background and Aim: Persistent corpus luteum (PCL) causes anestrus in mares. This study aimed to determine the effect of intrauterine prostaglandin F2α (PGF2α) treatment on PCL of racing mares to restore fertility.
Materials and Methods: Twelve racing mares suspected with PCL were diagnosed using transrectal palpation and confirmed by serum progesterone (P4) concentration measurement. PGF2α was infused intrauterine, followed by serum collection at 24, 48, and 72 h after. Estrous symptoms were monitored, and mating was conducted on day 3 of estrus with an earlier injection of 8.4 μg gonadotropin-releasing hormone twice a day. Transrectal palpation was performed on days 21-30 to observe the corpus luteum. Pregnancy diagnosis was performed rectally on 40-45 days post-mating and confirmed using Doppler ultrasound scanning.
Results: Eleven of the 12 mares had PCL. There was a dramatic reduction in the P4 concentration following PGF2α treatment of mares with PCL. All mares exhibited estrus 2.6±0.55 days post-treatment with a P4 concentration of 0.12±0.12 ng/mL. Rectal palpation and P4 concentration on 21-30 days after estrous onset showed that all mares were ovulating. The evaluation of P4 concentration on days 40-45 post-mating showed that all mares were still in the luteal phase. However, the pregnancy rate was only 54.5% based on rectal palpation and Doppler ultrasound scanning.
Conclusion: Treatment of PCL in racing mares with an intrauterine infusion of PGF2α restored the estrous cycle and induced ovulation and pregnancy. |
| first_indexed | 2024-12-22T12:29:42Z |
| format | Article |
| id | doaj.art-35fc8ca250154451aa01da60ca51bcd7 |
| institution | Directory Open Access Journal |
| issn | 0972-8988 2231-0916 |
| language | English |
| last_indexed | 2024-12-22T12:29:42Z |
| publishDate | 2021-09-01 |
| publisher | Veterinary World |
| record_format | Article |
| series | Veterinary World |
| spelling | doaj.art-35fc8ca250154451aa01da60ca51bcd72022-12-21T18:25:42ZengVeterinary WorldVeterinary World0972-89882231-09162021-09-011492356236110.14202/vetworld.2021.2356-2361Fertility restoration of racing mare with persistent corpus luteumTjok Gde Oka Pemayun0https://orcid.org/0000-0002-6443-6490Imam Mustofa1https://orcid.org/0000-0003-4543-1659Laba Mahaputra2https://orcid.org/0000-0001-8471-0293Herry Agoes Hermadi3https://orcid.org/0000-0003-2337-6716Ngakan Made Rai Wijaya4https://orcid.org/0000-0002-0863-1347Sri Mulyati5https://orcid.org/0000-0002-0193-4898Suzanita Utama6https://orcid.org/0000-0003-3907-5969Tjuk Imam Restiadi7https://orcid.org/0000-0001-9382-6546Rimayanti Rimayanti8https://orcid.org/0000-0002-6949-522XLaboratory of Veterinary Reproduction, Faculty of Veterinary Medicine, Udayana University, Jl. PB Sudirman, Denpasar, Bali 80233 Indonesia.Division of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Kampus C Mulyorejo, Surabaya 60115, Indonesia.Division of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Kampus C Mulyorejo, Surabaya 60115, Indonesia; Head Section of Health and Husbandry of the Indonesian Equestrian Association, East Java Region, Kampus C Mulyorejo, Surabaya 60115, Indonesia.Division of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Kampus C Mulyorejo, Surabaya 60115, Indonesia.Division of Basic Veterinary Medicine, Faculty of Veterinary Medicine, Universitas Airlangga, Kampus C Mulyorejo, Surabaya 60115, Indonesia.Division of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Kampus C Mulyorejo, Surabaya 60115, Indonesia.Division of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Kampus C Mulyorejo, Surabaya 60115, Indonesia.Division of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Kampus C Mulyorejo, Surabaya 60115, Indonesia.Division of Veterinary Reproduction, Faculty of Veterinary Medicine, Universitas Airlangga, Kampus C Mulyorejo, Surabaya 60115, Indonesia.Background and Aim: Persistent corpus luteum (PCL) causes anestrus in mares. This study aimed to determine the effect of intrauterine prostaglandin F2α (PGF2α) treatment on PCL of racing mares to restore fertility. Materials and Methods: Twelve racing mares suspected with PCL were diagnosed using transrectal palpation and confirmed by serum progesterone (P4) concentration measurement. PGF2α was infused intrauterine, followed by serum collection at 24, 48, and 72 h after. Estrous symptoms were monitored, and mating was conducted on day 3 of estrus with an earlier injection of 8.4 μg gonadotropin-releasing hormone twice a day. Transrectal palpation was performed on days 21-30 to observe the corpus luteum. Pregnancy diagnosis was performed rectally on 40-45 days post-mating and confirmed using Doppler ultrasound scanning. Results: Eleven of the 12 mares had PCL. There was a dramatic reduction in the P4 concentration following PGF2α treatment of mares with PCL. All mares exhibited estrus 2.6±0.55 days post-treatment with a P4 concentration of 0.12±0.12 ng/mL. Rectal palpation and P4 concentration on 21-30 days after estrous onset showed that all mares were ovulating. The evaluation of P4 concentration on days 40-45 post-mating showed that all mares were still in the luteal phase. However, the pregnancy rate was only 54.5% based on rectal palpation and Doppler ultrasound scanning. Conclusion: Treatment of PCL in racing mares with an intrauterine infusion of PGF2α restored the estrous cycle and induced ovulation and pregnancy.http://www.veterinaryworld.org/Vol.14/September-2021/9.pdfestrusfertilitygood health and well-beingovulationprogesteroneracing mare |
| spellingShingle | Tjok Gde Oka Pemayun Imam Mustofa Laba Mahaputra Herry Agoes Hermadi Ngakan Made Rai Wijaya Sri Mulyati Suzanita Utama Tjuk Imam Restiadi Rimayanti Rimayanti Fertility restoration of racing mare with persistent corpus luteum Veterinary World estrus fertility good health and well-being ovulation progesterone racing mare |
| title | Fertility restoration of racing mare with persistent corpus luteum |
| title_full | Fertility restoration of racing mare with persistent corpus luteum |
| title_fullStr | Fertility restoration of racing mare with persistent corpus luteum |
| title_full_unstemmed | Fertility restoration of racing mare with persistent corpus luteum |
| title_short | Fertility restoration of racing mare with persistent corpus luteum |
| title_sort | fertility restoration of racing mare with persistent corpus luteum |
| topic | estrus fertility good health and well-being ovulation progesterone racing mare |
| url | http://www.veterinaryworld.org/Vol.14/September-2021/9.pdf |
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