Asociación entre los alelos HLA-B40, HLA-DQA1*01 y HLA-DQB1*05 y respuesta de anticuerpos a la vacuna contra la hepatitis B en pacientes turcos en hemodiálisis
Introduction: Hepatitis B virus (HepB) infection is a global health problem with increasing cause of morbidity and mortality. Hemodialysis patients are especially vulnerable to HepB infection due to uremia-related immune dysfunction, frequent interventions they exposed, and health-care personnel’s u...
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| Format: | Article |
| Language: | Spanish |
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Asociación Regional de Diálisis y Trasplantes Renales de Capital Federal y Provincia de Buenos Aires
2019-09-01
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| Series: | Revista de Nefrología, Diálisis y Trasplante |
| Subjects: | |
| Online Access: | https://www.revistarenal.org.ar/index.php/rndt/article/view/461 |
| _version_ | 1818989144663130112 |
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| author | Gürsel Ersan Sibel Ersan Tülay Kılıcaslan Ayna |
| author_facet | Gürsel Ersan Sibel Ersan Tülay Kılıcaslan Ayna |
| author_sort | Gürsel Ersan |
| collection | DOAJ |
| description | Introduction: Hepatitis B virus (HepB) infection is a global health problem with increasing cause of morbidity and mortality. Hemodialysis patients are especially vulnerable to HepB infection due to uremia-related immune dysfunction, frequent interventions they exposed, and health-care personnel’s unsafe care. The vaccination against HepB confers the primary preventive measure. However, unresponsiveness to vaccination constitutes a major problem. Several factors can influence the immune response to vaccines but human genetic variations are thought to strongly militate the variability in vaccine responsiveness. We aimed to determine the association with specific HLA alleles and response to HepB vaccination in hemodialysis patients. Methods: The study included in-center hemodialysis patients. We retrospectively collected data regarding demographic, clinical, and laboratory features including anti-HBs antibody, antibody to hepatitis C (anti-HCV), anti-HIV, and specific HLA class I and II alleles (HLA-A, HLB, HLA-DR) from electronical medical record system. The frequencies of HLA class I and II antigens in nonresponders and responders were analyzed. Results: The most commonly observed HLA alleles in patients were DQA1*01 (%73.7), DQA1*05 (%57.9), DQB1*03 (%53.8), DQB1*05 (%38.5), and DRB1*11 (%37.3), respectively. The frequency of HLA-B40 allel was significantly higher in nonresponders (p=0.02, OR=6.25, 95% CI =1.33-29.3). HLA-DQA1*01 and HLA-DQB1*05 alleles were observed significantly more in responders (p=0.019, OR =6.9, 95% CI=1.40-33.91, and p=0.028, OR =10, 95% CI=1.12-88.91, respectively). Conclusion: This is the first study to our knowledge demonstrating the association between antibody response to HBsAg and HLA-B40, HLA-DQA1*01, and HLA-DQB1*05 alleles in Turkish hemodialysis patients. |
| first_indexed | 2024-12-20T19:33:49Z |
| format | Article |
| id | doaj.art-3601899a418046389df2ba3d7f589cd9 |
| institution | Directory Open Access Journal |
| issn | 0326-3428 2346-8548 |
| language | Spanish |
| last_indexed | 2024-12-20T19:33:49Z |
| publishDate | 2019-09-01 |
| publisher | Asociación Regional de Diálisis y Trasplantes Renales de Capital Federal y Provincia de Buenos Aires |
| record_format | Article |
| series | Revista de Nefrología, Diálisis y Trasplante |
| spelling | doaj.art-3601899a418046389df2ba3d7f589cd92022-12-21T19:28:42ZspaAsociación Regional de Diálisis y Trasplantes Renales de Capital Federal y Provincia de Buenos AiresRevista de Nefrología, Diálisis y Trasplante0326-34282346-85482019-09-01393167174399Asociación entre los alelos HLA-B40, HLA-DQA1*01 y HLA-DQB1*05 y respuesta de anticuerpos a la vacuna contra la hepatitis B en pacientes turcos en hemodiálisisGürsel Ersan0Sibel Ersan1Tülay Kılıcaslan Ayna2Department of Infectious Diseases and Clinical Microbiology, Izmir Tepecik Training and Research Hospital, Health Sciences University, IzmirDepartment of Nephrology, Izmir Tepecik Training and Research Hospital, Health Sciences University, IzmirDepartment of Medical Biology and Genetics, Izmir Tepecik Training and Research Hospital, Health Sciences University, IzmirIntroduction: Hepatitis B virus (HepB) infection is a global health problem with increasing cause of morbidity and mortality. Hemodialysis patients are especially vulnerable to HepB infection due to uremia-related immune dysfunction, frequent interventions they exposed, and health-care personnel’s unsafe care. The vaccination against HepB confers the primary preventive measure. However, unresponsiveness to vaccination constitutes a major problem. Several factors can influence the immune response to vaccines but human genetic variations are thought to strongly militate the variability in vaccine responsiveness. We aimed to determine the association with specific HLA alleles and response to HepB vaccination in hemodialysis patients. Methods: The study included in-center hemodialysis patients. We retrospectively collected data regarding demographic, clinical, and laboratory features including anti-HBs antibody, antibody to hepatitis C (anti-HCV), anti-HIV, and specific HLA class I and II alleles (HLA-A, HLB, HLA-DR) from electronical medical record system. The frequencies of HLA class I and II antigens in nonresponders and responders were analyzed. Results: The most commonly observed HLA alleles in patients were DQA1*01 (%73.7), DQA1*05 (%57.9), DQB1*03 (%53.8), DQB1*05 (%38.5), and DRB1*11 (%37.3), respectively. The frequency of HLA-B40 allel was significantly higher in nonresponders (p=0.02, OR=6.25, 95% CI =1.33-29.3). HLA-DQA1*01 and HLA-DQB1*05 alleles were observed significantly more in responders (p=0.019, OR =6.9, 95% CI=1.40-33.91, and p=0.028, OR =10, 95% CI=1.12-88.91, respectively). Conclusion: This is the first study to our knowledge demonstrating the association between antibody response to HBsAg and HLA-B40, HLA-DQA1*01, and HLA-DQB1*05 alleles in Turkish hemodialysis patients.https://www.revistarenal.org.ar/index.php/rndt/article/view/461hemodiálisisvacuna contra la hepatitis Bantígenos leucocitarios humanosrespuesta inmune |
| spellingShingle | Gürsel Ersan Sibel Ersan Tülay Kılıcaslan Ayna Asociación entre los alelos HLA-B40, HLA-DQA1*01 y HLA-DQB1*05 y respuesta de anticuerpos a la vacuna contra la hepatitis B en pacientes turcos en hemodiálisis Revista de Nefrología, Diálisis y Trasplante hemodiálisis vacuna contra la hepatitis B antígenos leucocitarios humanos respuesta inmune |
| title | Asociación entre los alelos HLA-B40, HLA-DQA1*01 y HLA-DQB1*05 y respuesta de anticuerpos a la vacuna contra la hepatitis B en pacientes turcos en hemodiálisis |
| title_full | Asociación entre los alelos HLA-B40, HLA-DQA1*01 y HLA-DQB1*05 y respuesta de anticuerpos a la vacuna contra la hepatitis B en pacientes turcos en hemodiálisis |
| title_fullStr | Asociación entre los alelos HLA-B40, HLA-DQA1*01 y HLA-DQB1*05 y respuesta de anticuerpos a la vacuna contra la hepatitis B en pacientes turcos en hemodiálisis |
| title_full_unstemmed | Asociación entre los alelos HLA-B40, HLA-DQA1*01 y HLA-DQB1*05 y respuesta de anticuerpos a la vacuna contra la hepatitis B en pacientes turcos en hemodiálisis |
| title_short | Asociación entre los alelos HLA-B40, HLA-DQA1*01 y HLA-DQB1*05 y respuesta de anticuerpos a la vacuna contra la hepatitis B en pacientes turcos en hemodiálisis |
| title_sort | asociacion entre los alelos hla b40 hla dqa1 01 y hla dqb1 05 y respuesta de anticuerpos a la vacuna contra la hepatitis b en pacientes turcos en hemodialisis |
| topic | hemodiálisis vacuna contra la hepatitis B antígenos leucocitarios humanos respuesta inmune |
| url | https://www.revistarenal.org.ar/index.php/rndt/article/view/461 |
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