The Neuropharmacological Evaluation of Seaweed: A Potential Therapeutic Source
The most common neurodegenerative diseases (NDDs), such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), are the seventh leading cause of mortality and morbidity in developed countries. Clinical observations of NDD patients are characterized by a progressive loss of neurons in the brain alo...
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| Format: | Article |
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MDPI AG
2023-11-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/22/2652 |
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| author | Khoshnur Jannat Rengasamy Balakrishnan Jun-Hyuk Han Ye-Ji Yu Ga-Won Kim Dong-Kug Choi |
| author_facet | Khoshnur Jannat Rengasamy Balakrishnan Jun-Hyuk Han Ye-Ji Yu Ga-Won Kim Dong-Kug Choi |
| author_sort | Khoshnur Jannat |
| collection | DOAJ |
| description | The most common neurodegenerative diseases (NDDs), such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), are the seventh leading cause of mortality and morbidity in developed countries. Clinical observations of NDD patients are characterized by a progressive loss of neurons in the brain along with memory decline. The common pathological hallmarks of NDDs include oxidative stress, the dysregulation of calcium, protein aggregation, a defective protein clearance system, mitochondrial dysfunction, neuroinflammation, neuronal apoptosis, and damage to cholinergic neurons. Therefore, managing this pathology requires screening drugs with different pathological targets, and suitable drugs for slowing the progression or prevention of NDDs remain to be discovered. Among the pharmacological strategies used to manage NDDs, natural drugs represent a promising therapeutic strategy. This review discusses the neuroprotective potential of seaweed and its bioactive compounds, and safety issues, which may provide several beneficial insights that warrant further investigation. |
| first_indexed | 2024-03-09T16:55:31Z |
| format | Article |
| id | doaj.art-360222348a3044c088aee1b892741981 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T16:55:31Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-360222348a3044c088aee1b8927419812023-11-24T14:35:30ZengMDPI AGCells2073-44092023-11-011222265210.3390/cells12222652The Neuropharmacological Evaluation of Seaweed: A Potential Therapeutic SourceKhoshnur Jannat0Rengasamy Balakrishnan1Jun-Hyuk Han2Ye-Ji Yu3Ga-Won Kim4Dong-Kug Choi5Department of Applied Life Sciences, Graduate School, Konkuk University, Chungju 27478, Republic of KoreaDepartment of Biotechnology, Research Institute of Inflammatory Disease (RID), College of Biomedical and Health Science, Konkuk University, Chungju 27478, Republic of KoreaDepartment of Applied Life Sciences, Graduate School, Konkuk University, Chungju 27478, Republic of KoreaDepartment of Applied Life Sciences, Graduate School, Konkuk University, Chungju 27478, Republic of KoreaDepartment of Applied Life Sciences, Graduate School, Konkuk University, Chungju 27478, Republic of KoreaDepartment of Applied Life Sciences, Graduate School, Konkuk University, Chungju 27478, Republic of KoreaThe most common neurodegenerative diseases (NDDs), such as Alzheimer’s disease (AD) and Parkinson’s disease (PD), are the seventh leading cause of mortality and morbidity in developed countries. Clinical observations of NDD patients are characterized by a progressive loss of neurons in the brain along with memory decline. The common pathological hallmarks of NDDs include oxidative stress, the dysregulation of calcium, protein aggregation, a defective protein clearance system, mitochondrial dysfunction, neuroinflammation, neuronal apoptosis, and damage to cholinergic neurons. Therefore, managing this pathology requires screening drugs with different pathological targets, and suitable drugs for slowing the progression or prevention of NDDs remain to be discovered. Among the pharmacological strategies used to manage NDDs, natural drugs represent a promising therapeutic strategy. This review discusses the neuroprotective potential of seaweed and its bioactive compounds, and safety issues, which may provide several beneficial insights that warrant further investigation.https://www.mdpi.com/2073-4409/12/22/2652neurodegenerative diseaseagingneuroinflammationseaweedbioactive compounds |
| spellingShingle | Khoshnur Jannat Rengasamy Balakrishnan Jun-Hyuk Han Ye-Ji Yu Ga-Won Kim Dong-Kug Choi The Neuropharmacological Evaluation of Seaweed: A Potential Therapeutic Source Cells neurodegenerative disease aging neuroinflammation seaweed bioactive compounds |
| title | The Neuropharmacological Evaluation of Seaweed: A Potential Therapeutic Source |
| title_full | The Neuropharmacological Evaluation of Seaweed: A Potential Therapeutic Source |
| title_fullStr | The Neuropharmacological Evaluation of Seaweed: A Potential Therapeutic Source |
| title_full_unstemmed | The Neuropharmacological Evaluation of Seaweed: A Potential Therapeutic Source |
| title_short | The Neuropharmacological Evaluation of Seaweed: A Potential Therapeutic Source |
| title_sort | neuropharmacological evaluation of seaweed a potential therapeutic source |
| topic | neurodegenerative disease aging neuroinflammation seaweed bioactive compounds |
| url | https://www.mdpi.com/2073-4409/12/22/2652 |
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