Gut Microbiota – A Potential Contributor in the Pathogenesis of Bipolar Disorder
Bipolar disorder (BD) is one of the major psychiatric disorders that is characterized by recurrent episodes of depression and mania (or hypomania), leading to seriously adverse outcomes with unclear pathogenesis. There is an underlying relationship between bacterial communities residing in the gut a...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-03-01
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| Series: | Frontiers in Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.830748/full |
| _version_ | 1819173721951174656 |
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| author | Peifen Zhang Peifen Zhang Lingzhuo Kong Huimin Huang Yanmeng Pan Danhua Zhang Jiajun Jiang Yuting Shen Caixi Xi Jianbo Lai Jianbo Lai Jianbo Lai Jianbo Lai Chee H. Ng Shaohua Hu Shaohua Hu Shaohua Hu Shaohua Hu |
| author_facet | Peifen Zhang Peifen Zhang Lingzhuo Kong Huimin Huang Yanmeng Pan Danhua Zhang Jiajun Jiang Yuting Shen Caixi Xi Jianbo Lai Jianbo Lai Jianbo Lai Jianbo Lai Chee H. Ng Shaohua Hu Shaohua Hu Shaohua Hu Shaohua Hu |
| author_sort | Peifen Zhang |
| collection | DOAJ |
| description | Bipolar disorder (BD) is one of the major psychiatric disorders that is characterized by recurrent episodes of depression and mania (or hypomania), leading to seriously adverse outcomes with unclear pathogenesis. There is an underlying relationship between bacterial communities residing in the gut and brain function, which together form the gut-brain axis (GBA). Recent studies have shown that changes in the gut microbiota have been observed in a large number of BD patients, so the axis may play a role in the pathogenesis of BD. This review summarizes briefly the relationship between the GBA and brain function, the composition and changes of gut microbiota in patients with BD, and further explores the potential role of GBA-related pathway in the pathogenesis of BD as well as the limitations in this field at present in order to provide new ideas for the future etiology research and drug development. |
| first_indexed | 2024-12-22T20:27:35Z |
| format | Article |
| id | doaj.art-3602e53daf09402aba184abae8027c05 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-12-22T20:27:35Z |
| publishDate | 2022-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-3602e53daf09402aba184abae8027c052022-12-21T18:13:41ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-03-011610.3389/fnins.2022.830748830748Gut Microbiota – A Potential Contributor in the Pathogenesis of Bipolar DisorderPeifen Zhang0Peifen Zhang1Lingzhuo Kong2Huimin Huang3Yanmeng Pan4Danhua Zhang5Jiajun Jiang6Yuting Shen7Caixi Xi8Jianbo Lai9Jianbo Lai10Jianbo Lai11Jianbo Lai12Chee H. Ng13Shaohua Hu14Shaohua Hu15Shaohua Hu16Shaohua Hu17Department of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaMOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, ChinaDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Psychiatry, Wenzhou Medical University, Wenzhou, ChinaDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Psychiatry, Wenzhou Medical University, Wenzhou, ChinaDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaMOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, ChinaThe Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou, ChinaBrain Research Institute, Zhejiang University, Hangzhou, ChinaDepartment of Psychiatry, The Melbourne Clinic and St Vincent’s Hospital, University of Melbourne, Richmond, VIC, AustraliaDepartment of Psychiatry, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaMOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou, ChinaThe Key Laboratory of Mental Disorder Management in Zhejiang Province, Hangzhou, ChinaBrain Research Institute, Zhejiang University, Hangzhou, ChinaBipolar disorder (BD) is one of the major psychiatric disorders that is characterized by recurrent episodes of depression and mania (or hypomania), leading to seriously adverse outcomes with unclear pathogenesis. There is an underlying relationship between bacterial communities residing in the gut and brain function, which together form the gut-brain axis (GBA). Recent studies have shown that changes in the gut microbiota have been observed in a large number of BD patients, so the axis may play a role in the pathogenesis of BD. This review summarizes briefly the relationship between the GBA and brain function, the composition and changes of gut microbiota in patients with BD, and further explores the potential role of GBA-related pathway in the pathogenesis of BD as well as the limitations in this field at present in order to provide new ideas for the future etiology research and drug development.https://www.frontiersin.org/articles/10.3389/fnins.2022.830748/fullbipolar disordergut microbiotagut-brain axispathogenesistreatment |
| spellingShingle | Peifen Zhang Peifen Zhang Lingzhuo Kong Huimin Huang Yanmeng Pan Danhua Zhang Jiajun Jiang Yuting Shen Caixi Xi Jianbo Lai Jianbo Lai Jianbo Lai Jianbo Lai Chee H. Ng Shaohua Hu Shaohua Hu Shaohua Hu Shaohua Hu Gut Microbiota – A Potential Contributor in the Pathogenesis of Bipolar Disorder Frontiers in Neuroscience bipolar disorder gut microbiota gut-brain axis pathogenesis treatment |
| title | Gut Microbiota – A Potential Contributor in the Pathogenesis of Bipolar Disorder |
| title_full | Gut Microbiota – A Potential Contributor in the Pathogenesis of Bipolar Disorder |
| title_fullStr | Gut Microbiota – A Potential Contributor in the Pathogenesis of Bipolar Disorder |
| title_full_unstemmed | Gut Microbiota – A Potential Contributor in the Pathogenesis of Bipolar Disorder |
| title_short | Gut Microbiota – A Potential Contributor in the Pathogenesis of Bipolar Disorder |
| title_sort | gut microbiota a potential contributor in the pathogenesis of bipolar disorder |
| topic | bipolar disorder gut microbiota gut-brain axis pathogenesis treatment |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.830748/full |
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