IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPER
This study was aimed to evaluate the antiproliferative activity of the mixed-ligand complex (chloro(N-phenyl-N'-[(pyridin-2-yl)methylidene]carbamohydrazonothioato)(4-aminobenzene-1-sulfonamide)copper) on several cancer cells of lines. It was established, that the copper(II) mixed-ligand complex...
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| Format: | Article |
| Language: | English |
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Moldova State University
2018-12-01
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| Series: | Studia Universitatis Moldaviae: Stiinte reale si ale naturii |
| Online Access: | https://ojs.studiamsu.md/index.php/stiinte_reale_naturii/article/view/1028 |
| _version_ | 1811202287259877376 |
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| author | USM ADMIN |
| author_facet | USM ADMIN |
| author_sort | USM ADMIN |
| collection | DOAJ |
| description | This study was aimed to evaluate the antiproliferative activity of the mixed-ligand complex (chloro(N-phenyl-N'-[(pyridin-2-yl)methylidene]carbamohydrazonothioato)(4-aminobenzene-1-sulfonamide)copper) on several cancer cells of lines. It was established, that the copper(II) mixed-ligand complex exhibits the highest anticancer activity against MeW-164, HeLa, BxPC-3 and RD cells of lines with IC50 values of 1.0±0.2, 0.4±0.04, 1.7±0.2, 1.3±0.3 μM, respectively. A comparative study between the tested compound and DOXO in regard to cancer lines has established that the tested copper(II) mixed-ligand complex exhibits stronger inhibitory activity on cancer cells proliferation than doxorubicin and cisplatin.
Keywords: mixed-ligand complex, doxorubicin, cisplatin, anticancer activity, cancer cells of line.
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| first_indexed | 2024-04-12T02:37:27Z |
| format | Article |
| id | doaj.art-3604c902b0404c058887086bc72146f3 |
| institution | Directory Open Access Journal |
| issn | 1814-3237 1857-498X |
| language | English |
| last_indexed | 2024-04-12T02:37:27Z |
| publishDate | 2018-12-01 |
| publisher | Moldova State University |
| record_format | Article |
| series | Studia Universitatis Moldaviae: Stiinte reale si ale naturii |
| spelling | doaj.art-3604c902b0404c058887086bc72146f32022-12-22T03:51:28ZengMoldova State UniversityStudia Universitatis Moldaviae: Stiinte reale si ale naturii1814-32371857-498X2018-12-016IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPERUSM ADMIN0Studia Universitas MoldaviaeThis study was aimed to evaluate the antiproliferative activity of the mixed-ligand complex (chloro(N-phenyl-N'-[(pyridin-2-yl)methylidene]carbamohydrazonothioato)(4-aminobenzene-1-sulfonamide)copper) on several cancer cells of lines. It was established, that the copper(II) mixed-ligand complex exhibits the highest anticancer activity against MeW-164, HeLa, BxPC-3 and RD cells of lines with IC50 values of 1.0±0.2, 0.4±0.04, 1.7±0.2, 1.3±0.3 μM, respectively. A comparative study between the tested compound and DOXO in regard to cancer lines has established that the tested copper(II) mixed-ligand complex exhibits stronger inhibitory activity on cancer cells proliferation than doxorubicin and cisplatin. Keywords: mixed-ligand complex, doxorubicin, cisplatin, anticancer activity, cancer cells of line. https://ojs.studiamsu.md/index.php/stiinte_reale_naturii/article/view/1028 |
| spellingShingle | USM ADMIN IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPER Studia Universitatis Moldaviae: Stiinte reale si ale naturii |
| title | IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPER |
| title_full | IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPER |
| title_fullStr | IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPER |
| title_full_unstemmed | IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPER |
| title_short | IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPER |
| title_sort | in vitro anticancer activity of chloro n phenyl n pyridin 2 yl methylidene carbamohydrazonothioato 4 aminobenzene 1 sulfonamide copper |
| url | https://ojs.studiamsu.md/index.php/stiinte_reale_naturii/article/view/1028 |
| work_keys_str_mv | AT usmadmin invitroanticanceractivityofchloronphenylnpyridin2ylmethylidenecarbamohydrazonothioato4aminobenzene1sulfonamidecopper |