IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPER
This study was aimed to evaluate the antiproliferative activity of the mixed-ligand complex (chloro(N-phenyl-N'-[(pyridin-2-yl)methylidene]carbamohydrazonothioato)(4-aminobenzene-1-sulfonamide)copper) on several cancer cells of lines. It was established, that the copper(II) mixed-ligand complex...
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Format: | Article |
Language: | English |
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Moldova State University
2018-12-01
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Series: | Studia Universitatis Moldaviae: Stiinte reale si ale naturii |
Online Access: | https://ojs.studiamsu.md/index.php/stiinte_reale_naturii/article/view/1028 |
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author | USM ADMIN |
author_facet | USM ADMIN |
author_sort | USM ADMIN |
collection | DOAJ |
description | This study was aimed to evaluate the antiproliferative activity of the mixed-ligand complex (chloro(N-phenyl-N'-[(pyridin-2-yl)methylidene]carbamohydrazonothioato)(4-aminobenzene-1-sulfonamide)copper) on several cancer cells of lines. It was established, that the copper(II) mixed-ligand complex exhibits the highest anticancer activity against MeW-164, HeLa, BxPC-3 and RD cells of lines with IC50 values of 1.0±0.2, 0.4±0.04, 1.7±0.2, 1.3±0.3 μM, respectively. A comparative study between the tested compound and DOXO in regard to cancer lines has established that the tested copper(II) mixed-ligand complex exhibits stronger inhibitory activity on cancer cells proliferation than doxorubicin and cisplatin.
Keywords: mixed-ligand complex, doxorubicin, cisplatin, anticancer activity, cancer cells of line.
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first_indexed | 2024-04-12T02:37:27Z |
format | Article |
id | doaj.art-3604c902b0404c058887086bc72146f3 |
institution | Directory Open Access Journal |
issn | 1814-3237 1857-498X |
language | English |
last_indexed | 2024-04-12T02:37:27Z |
publishDate | 2018-12-01 |
publisher | Moldova State University |
record_format | Article |
series | Studia Universitatis Moldaviae: Stiinte reale si ale naturii |
spelling | doaj.art-3604c902b0404c058887086bc72146f32022-12-22T03:51:28ZengMoldova State UniversityStudia Universitatis Moldaviae: Stiinte reale si ale naturii1814-32371857-498X2018-12-016IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPERUSM ADMIN0Studia Universitas MoldaviaeThis study was aimed to evaluate the antiproliferative activity of the mixed-ligand complex (chloro(N-phenyl-N'-[(pyridin-2-yl)methylidene]carbamohydrazonothioato)(4-aminobenzene-1-sulfonamide)copper) on several cancer cells of lines. It was established, that the copper(II) mixed-ligand complex exhibits the highest anticancer activity against MeW-164, HeLa, BxPC-3 and RD cells of lines with IC50 values of 1.0±0.2, 0.4±0.04, 1.7±0.2, 1.3±0.3 μM, respectively. A comparative study between the tested compound and DOXO in regard to cancer lines has established that the tested copper(II) mixed-ligand complex exhibits stronger inhibitory activity on cancer cells proliferation than doxorubicin and cisplatin. Keywords: mixed-ligand complex, doxorubicin, cisplatin, anticancer activity, cancer cells of line. https://ojs.studiamsu.md/index.php/stiinte_reale_naturii/article/view/1028 |
spellingShingle | USM ADMIN IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPER Studia Universitatis Moldaviae: Stiinte reale si ale naturii |
title | IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPER |
title_full | IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPER |
title_fullStr | IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPER |
title_full_unstemmed | IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPER |
title_short | IN VITRO ANTICANCER ACTIVITY OF CHLORO(N-PHENYL-N'-[(PYRIDIN-2-YL)METHYLIDENE]CARBAMOHYDRAZONOTHIOATO) (4-AMINOBENZENE-1-SULFONAMIDE)COPPER |
title_sort | in vitro anticancer activity of chloro n phenyl n pyridin 2 yl methylidene carbamohydrazonothioato 4 aminobenzene 1 sulfonamide copper |
url | https://ojs.studiamsu.md/index.php/stiinte_reale_naturii/article/view/1028 |
work_keys_str_mv | AT usmadmin invitroanticanceractivityofchloronphenylnpyridin2ylmethylidenecarbamohydrazonothioato4aminobenzene1sulfonamidecopper |