Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies
Abstract Targeted drug delivery is one of the attractive ways in which cancer treatment can significantly reduce side effects. In the last two decades, the use of antibodies as a tool for accurate detection of cancer has been noted. On the other hand, the binding of drugs and carriers containing dru...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2024-02-01
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| Series: | Cancer Cell International |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12935-024-03259-8 |
| _version_ | 1797273154756804608 |
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| author | Mohadeseh Haji Abdolvahab Pegah Karimi Nasrin Mohajeri Mohammad Abedini Hamed Zare |
| author_facet | Mohadeseh Haji Abdolvahab Pegah Karimi Nasrin Mohajeri Mohammad Abedini Hamed Zare |
| author_sort | Mohadeseh Haji Abdolvahab |
| collection | DOAJ |
| description | Abstract Targeted drug delivery is one of the attractive ways in which cancer treatment can significantly reduce side effects. In the last two decades, the use of antibodies as a tool for accurate detection of cancer has been noted. On the other hand, the binding of drugs and carriers containing drugs to the specific antibodies of cancer cells can specifically target only these cells. However, the use of whole antibodies brings challenges, including their large size, the complexity of conjugation, the high cost of production, and the creation of immunogenic reactions in the body. The use of nanobodies, or VHHs, which are a small part of camel heavy chain antibodies, is very popular due to their small size, high craftsmanship, and low production cost. In this article, in addition to a brief overview of the structure and characteristics of nanobodies, the use of this molecule in the targeted drug delivery of breast cancer has been reviewed. |
| first_indexed | 2024-03-07T14:39:32Z |
| format | Article |
| id | doaj.art-36054b83344d4ff59b8b241bbe0d662b |
| institution | Directory Open Access Journal |
| issn | 1475-2867 |
| language | English |
| last_indexed | 2024-03-07T14:39:32Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Cell International |
| spelling | doaj.art-36054b83344d4ff59b8b241bbe0d662b2024-03-05T20:25:30ZengBMCCancer Cell International1475-28672024-02-0124111810.1186/s12935-024-03259-8Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodiesMohadeseh Haji Abdolvahab0Pegah Karimi1Nasrin Mohajeri2Mohammad Abedini3Hamed Zare4Recombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECRRecombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECRRecombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECRRecombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECRRecombinant Proteins Department, Breast Cancer Research Center, Motamed Cancer Institute, ACECRAbstract Targeted drug delivery is one of the attractive ways in which cancer treatment can significantly reduce side effects. In the last two decades, the use of antibodies as a tool for accurate detection of cancer has been noted. On the other hand, the binding of drugs and carriers containing drugs to the specific antibodies of cancer cells can specifically target only these cells. However, the use of whole antibodies brings challenges, including their large size, the complexity of conjugation, the high cost of production, and the creation of immunogenic reactions in the body. The use of nanobodies, or VHHs, which are a small part of camel heavy chain antibodies, is very popular due to their small size, high craftsmanship, and low production cost. In this article, in addition to a brief overview of the structure and characteristics of nanobodies, the use of this molecule in the targeted drug delivery of breast cancer has been reviewed.https://doi.org/10.1186/s12935-024-03259-8VHHNanobodyDrug deliveryBreast cancer |
| spellingShingle | Mohadeseh Haji Abdolvahab Pegah Karimi Nasrin Mohajeri Mohammad Abedini Hamed Zare Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies Cancer Cell International VHH Nanobody Drug delivery Breast cancer |
| title | Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies |
| title_full | Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies |
| title_fullStr | Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies |
| title_full_unstemmed | Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies |
| title_short | Targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells: the most attractive application of nanobodies |
| title_sort | targeted drug delivery using nanobodies to deliver effective molecules to breast cancer cells the most attractive application of nanobodies |
| topic | VHH Nanobody Drug delivery Breast cancer |
| url | https://doi.org/10.1186/s12935-024-03259-8 |
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