The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed <i>Ecklonia maxima</i> in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities
Sulfated polysaccharides prepared from marine algae are potential ingredients in nutraceutical, pharmaceutical, and cosmeceutical industries. In the present study, the antioxidant, anti-melanogenesis, and photoprotective effects of sulfated polysaccharides obtained from <i>Ecklonia maxima</...
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MDPI AG
2020-08-01
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| Series: | Antioxidants |
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| Online Access: | https://www.mdpi.com/2076-3921/9/8/724 |
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| author | Lei Wang Thilina U. Jayawardena Hye-Won Yang Hyo-Geun Lee You-Jin Jeon |
| author_facet | Lei Wang Thilina U. Jayawardena Hye-Won Yang Hyo-Geun Lee You-Jin Jeon |
| author_sort | Lei Wang |
| collection | DOAJ |
| description | Sulfated polysaccharides prepared from marine algae are potential ingredients in nutraceutical, pharmaceutical, and cosmeceutical industries. In the present study, the antioxidant, anti-melanogenesis, and photoprotective effects of sulfated polysaccharides obtained from <i>Ecklonia maxima</i> (EMC) were investigated to evaluate their potential in cosmetic. EMC was successfully prepared through Celluclast-assisted extraction and ethanol precipitation, and it contained 79.88% of sulfated polysaccharides that with 69.37% carbohydrates and 10.51% sulfate. EMC effectively suppressed 2,2-azobis(2-amidinopropane) hydrochloride (AAPH)-induced oxidative stress in vitro in Vero cells and in vivo in zebrafish. Furthermore, EMC significantly inhibited mushroom tyrosinase and reduced melanin synthesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 cells. In addition, EMC remarkably attenuated photodamage induced by UVB irradiation in vitro in human keratinocytes (HaCaT cells) and in vivo in zebrafish. Furthermore, EMC effectively inhibited wrinkle-related enzymes and improved collagen synthesis in UVB-irradiated human dermal fibroblasts (HDF cells). These results indicate that EMC possesses strong antioxidant, anti-melanogenesis, and photoprotective activities, and suggest that EMC may be an ideal ingredient in the pharmaceutical and cosmeceutical industries. |
| first_indexed | 2024-03-10T17:44:40Z |
| format | Article |
| id | doaj.art-3606544e4ae847579e64bd3cdacd3288 |
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| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-10T17:44:40Z |
| publishDate | 2020-08-01 |
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| series | Antioxidants |
| spelling | doaj.art-3606544e4ae847579e64bd3cdacd32882023-11-20T09:34:59ZengMDPI AGAntioxidants2076-39212020-08-019872410.3390/antiox9080724The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed <i>Ecklonia maxima</i> in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective ActivitiesLei Wang0Thilina U. Jayawardena1Hye-Won Yang2Hyo-Geun Lee3You-Jin Jeon4Department of Marine Life Sciences, Jeju National University, Jeju Self-Governing Province, Jeju 63243, KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju Self-Governing Province, Jeju 63243, KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju Self-Governing Province, Jeju 63243, KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju Self-Governing Province, Jeju 63243, KoreaDepartment of Marine Life Sciences, Jeju National University, Jeju Self-Governing Province, Jeju 63243, KoreaSulfated polysaccharides prepared from marine algae are potential ingredients in nutraceutical, pharmaceutical, and cosmeceutical industries. In the present study, the antioxidant, anti-melanogenesis, and photoprotective effects of sulfated polysaccharides obtained from <i>Ecklonia maxima</i> (EMC) were investigated to evaluate their potential in cosmetic. EMC was successfully prepared through Celluclast-assisted extraction and ethanol precipitation, and it contained 79.88% of sulfated polysaccharides that with 69.37% carbohydrates and 10.51% sulfate. EMC effectively suppressed 2,2-azobis(2-amidinopropane) hydrochloride (AAPH)-induced oxidative stress in vitro in Vero cells and in vivo in zebrafish. Furthermore, EMC significantly inhibited mushroom tyrosinase and reduced melanin synthesis in alpha-melanocyte-stimulating hormone-stimulated B16F10 cells. In addition, EMC remarkably attenuated photodamage induced by UVB irradiation in vitro in human keratinocytes (HaCaT cells) and in vivo in zebrafish. Furthermore, EMC effectively inhibited wrinkle-related enzymes and improved collagen synthesis in UVB-irradiated human dermal fibroblasts (HDF cells). These results indicate that EMC possesses strong antioxidant, anti-melanogenesis, and photoprotective activities, and suggest that EMC may be an ideal ingredient in the pharmaceutical and cosmeceutical industries.https://www.mdpi.com/2076-3921/9/8/724<i>Ecklonia maxima</i>sulfated polysaccharidesoxidative stressmelanogenesisUVB irradiation |
| spellingShingle | Lei Wang Thilina U. Jayawardena Hye-Won Yang Hyo-Geun Lee You-Jin Jeon The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed <i>Ecklonia maxima</i> in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities Antioxidants <i>Ecklonia maxima</i> sulfated polysaccharides oxidative stress melanogenesis UVB irradiation |
| title | The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed <i>Ecklonia maxima</i> in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities |
| title_full | The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed <i>Ecklonia maxima</i> in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities |
| title_fullStr | The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed <i>Ecklonia maxima</i> in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities |
| title_full_unstemmed | The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed <i>Ecklonia maxima</i> in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities |
| title_short | The Potential of Sulfated Polysaccharides Isolated from the Brown Seaweed <i>Ecklonia maxima</i> in Cosmetics: Antioxidant, Anti-melanogenesis, and Photoprotective Activities |
| title_sort | potential of sulfated polysaccharides isolated from the brown seaweed i ecklonia maxima i in cosmetics antioxidant anti melanogenesis and photoprotective activities |
| topic | <i>Ecklonia maxima</i> sulfated polysaccharides oxidative stress melanogenesis UVB irradiation |
| url | https://www.mdpi.com/2076-3921/9/8/724 |
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