Novel frataxin isoforms may contribute to the pathological mechanism of Friedreich ataxia.

Novel frataxin isoforms may contribute to the pathological mechanism of Friedreich ataxia.

Friedreich ataxia (FRDA) is an inherited neurodegenerative disease caused by frataxin (FXN) deficiency. The nervous system and heart are the most severely affected tissues. However, highly mitochondria-dependent tissues, such as kidney and liver, are not obviously affected, although the abundance of...

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Bibliographic Details
Main Authors: Haiyan Xia, Yun Cao, Xiaoman Dai, Zvonimir Marelja, Di Zhou, Ran Mo, Sahar Al-Mahdawi, Mark A Pook, Silke Leimkühler, Tracey A Rouault, Kuanyu Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3474739?pdf=render

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